Laura C Sommerfeld, Andrew P Holmes, Ting Y Yu, Christopher O'Shea, Deirdre M Kavanagh, Jeremy M Pike, Thomas Wright, Fahima Syeda, Areej Aljehani, Tania Kew, Victor R Cardoso, S Nashitha Kabir, Claire Hepburn, Priyanka R Menon, Sophie Broadway-Stringer, Molly O'Reilly, Anika Witten, Lisa Fortmueller, Susanne Lutz, Alexandra Kulle, Georgios V Gkoutos, Davor Pavlovic, Wiebke Arlt, Gareth G Lavery, Richard Steeds, Katja Gehmlich, Monika Stoll, Paulus Kirchhof, Larissa Fabritz
Androgenic anabolic steroids (AAS) are commonly abused by young men. Male sex and increased AAS levels are associated with earlier and more severe manifestation of common cardiac conditions, such as atrial fibrillation, and rare ones, such as arrhythmogenic right ventricular cardiomyopathy (ARVC). Clinical observations suggest a potential atrial involvement in ARVC. Arrhythmogenic right ventricular cardiomyopathy is caused by desmosomal gene defects, including reduced plakoglobin expression. Here, we analysed clinical records from 146 ARVC patients to identify that ARVC is more common in males than females...
February 12, 2024: Journal of Physiology