C A Porcar Plana, E Rico Santos, J L Losa García, E Campos Mollo
Cutaneous anaplastic large-cell lymphoma (cALCL) is a condition within CD30 lymphoid proliferations spectrum. Involving the eyelid is unusual and all cases found in the literature are located in the upper eyelid. In this case we report an cALCL atypical presentation. A 39 year-old woman with no significant medical history, presents a fast-growing mass in the medial canthus, with inflamatory-infectious appearance. After a week with antibiotics with no response, an excisional biopsy was practiced. The hystopathology analysis with a negative systemic work up confirmed the diagnosis of a cALCL...
June 5, 2020: Archivos de la Sociedad Española de Oftalmología
Xiaoyan Wang, Shakir M Saud, Fang Wang, Shengqi He, Xiwen Zhang, Baojin Hua, Weidong Li
ETHNOPHARMACOLOGICAL RELEVANCE: Ulcerative colitis were prone to develop into ulcerrelated colorectal cancer with high risk of mortality. Shaoyao Decoction (SYD), a compound prescription of Chinese traditional medicine, was reported to have anti-colorectal cancer effect. Thus this study mainly investigated the protective and preventive effect of SYD against oxidative damages and inflamatory response through in vivo and in vitro experiments. AIM OF THE STUDY: Shaoyao decoction (SYD), a compound prescription of traditional Chinese medicine, is effective in treating ulcerative colitis...
January 22, 2020: Journal of Ethnopharmacology
Marta Martínez-Guitián, Juan C Vázquez-Ucha, Laura Álvarez-Fraga, Kelly Conde-Pérez, Cristina Lasarte-Monterrubio, Juan Andrés Vallejo, Germán Bou, Margarita Poza, Alejandro Beceiro
Acinetobacter baumannii is currently considered one of the most problematic nosocomial microorganisms. In the present work the hisF gene from the ATCC 17978 strain and the AbH12O-A2 clinical isolate of A. baumannii was found over-expressed during the course of murine pneumonia infections. The study demonstrated that the A. baumannii ATCC 17978 mutant strain lacking the hisF gene induces a sub-lethal pneumonia infection in mice, while the complemented mutant strain increased its virulence. This histidine auxotroph mutant showed an increase on IL-6 secretion and leukocytes recruitment during infections...
2019: Frontiers in Cellular and Infection Microbiology
Francisco Javier Zamora-Camacho
Habitat alterations in agroecosystems may damage amphibian immune capacity. As agroecosystem extension is increasing worldwide, broader-context knowledge on the effects of agroecosystem stressful conditions on amphibian immune capacity is crucial for understanding and management of amphibian global declines. However, most studies on ecoimmunology assume synchronal among-group immune-response peaks, and focus on immune response after standardized time lapses, neglecting its progression. Herein, I compared inflamatory response short-term progression of agroecosystem and natural-habitat female and male natterjack toads Epidalea calamita , by measuring swelling response, once per hour, 6 h following an artificial immune challenge with innocuous antigen phytohemagglutinin...
April 2019: Current Zoology
Jasminka Petrovic, Nermin Salkic, Dilista Piljic, Sead Ahmetagic, Rahima Jahic, Humera Porobic, Arnela Smriko-Nuhanovic, Mevludin Hasanovic
Introduction: Chronic HCV infection is chronic inflamatory liver disease caused by hepatitis C virus. Anti HCV prevalence among intravenous drug users (IVDU) is very high and it accounts 40% -90% (60%-90%) with the risk of 80% of developing the chronic infection. Aim: The aims of this study were: a) to compare clinical characteristics of chronic HCV infection among IVDU and non-users population and to detect their impact to treatment outcome; b) to investigate the treatment efficacy comparing sustained viral response (SVR) in these two populations in Tuzla Canton...
December 2018: Materia Socio-medica
Gunapathy Devi, Ramasamy Harikrishnan, Bilal Ahmad Paray, Mohammad K Al-Sadoon, Seyed Hossein Hoseinifar, Chellam Balasundaram
The effect of aloe-emodin incorporated diets on innate immune response, disease resistance, pro and/or anti-inflammatory cytokine gene transcription in Labeo rohita against Aphanomyces invadans is reported for the first time. In healthy and infected groups fed with 5 mg aloe-emodin enriched diet the white blood cell (WBC) count increased significantly (p > 0.05) after 6th week. In both groups fed with any enriched diet the biochemical parameters such as albumin, globulin, and albumin/globulin ratio did not vary significantly; however with 5 mg aloe-emodin diet the albumin and globulin levels increased significantly (p > 0...
February 9, 2019: Fish & Shellfish Immunology
Francina Escobar-Arregoces, Catalina Latorre-Uriza, Juliana Velosa-Porras, Nelly Roa-Molina, Alvaro J Ruiz, Jaime Silva, Estefania Arias, Juliana Echeverri
Periodontal disease and its inflammatory response have been related to adverse outcomes in pregnancy such as preterm birth, preeclampsia and low birth weight. This study analyzed systemic inflammatory response in patients with high risk of preterm delivery and its relationship to periodontal disease. A pilot study was conducted for a case and control study, on 23 patients at risk of preterm delivery and 23 patients without risk of preterm delivery as controls. Exclusion criteria were patients who had received periodontal treatment, antibiotic or antimicrobial agents within the past three months, or with infections or baseline diseases such as diabetes or hypercholesterolemia...
June 2018: Acta Odontológica Latinoamericana: AOL
Pedro Henrique Scheidt Figueiredo, Márcia Maria Oliveira Lima, Henrique Silveira Costa, Jeanne Brenda Martins, Olga Dumont Flecha, Patrícia Furtado Gonçalves, Frederico Lopes Alves, Vanessa Gomes Brandão Rodrigues, Emílio Henrique Barroso Maciel, Vanessa Amaral Mendonça, Ana Cristina Rodrigues Lacerda, Érica Leandro Marciano Vieira, Antônio Lúcio Teixeira, Fabrício de Paula, Cláudio Heitor Balthazar
OBJECTIVE: Evaluate and compare the isolated and combined effects of Inspiratory Muscle Training (IMT) and Aerobic Training (AT) on respiratory and functional parameters, inflamatory biomarkers, redox status and health-related quality of life (HRQoL) in hemodialysis patients. METHODS: A randomised controlled trial with factorial allocation and intention-to-treat analysis was performed in hemodialysis patients. Volunteers were randomly assigned to performe 8-weeks of IMT at 50% of maximal inspiratory pressure (MIP), low intensity AT or combined training (CT)...
2018: PloS One
Carlos Roberto Emerenciano Bueno, Diego Valentim, Élerson Gaetti Jardim Junior, Daniela Nardi Mancuso, Gustavo Sivieri-Araujo, Rogerio Castilho Jacinto, Luciano Tavares Angelo Cintra, Eloi Dezan-Junior
Based on aroeira's (Myracrodruon urundeuva) antimicrobial activity and a future trend to compose intracanal medication, the aim of this study was to assess in vivo inflamatory tissue response to the extracts by edemogenic and histological analysis containing inactivated facultative and anaerobic microorganisms. For edema quantification, eighteen animals were divided into three groups (n = 3, periods: 3 and 6 hours) and 0.2 mL of 1% Evans blue per 100 g of body weight was injected into the penile vein under general anesthesia...
May 24, 2018: Brazilian Oral Research
Trinidad Hasbún, Ximena Chaparro, Viera Kaplan, Felipe Cavagnaro, Alex Castro
Henoch-Schönlein purpura (HSP) or IgA Vasculitis is the most common childhood vasculitis. The classic tetrad of signs and symptoms include palpable purpura, arthralgia, abdominal pain and renal disease. The occurrence of hemorrhagic bullae in children with HSP is rarely encountered. Objec tive: To report an unusual cutaneous manifestation of HSP in children. CASE REPORT: A 14-year-old girl complained about a 2-week painful bullous rash in both lower extremities and multiple arthral gias...
February 2018: Revista Chilena de Pediatría
Maria Chiara Marchesi, Cecilia C. Timpano, Sara Busechian, Camillo Pieramati, Fabrizio Rueca
The term inflammatory bowel diseases (IBD) refers to a group of idiopathic, chronic intestinal diseases characterized by a diffuse infiltration of inflammatory cells into the lamina propria of the intestine. The pathogenesis of IBD is unknown. The most common signs described are diarrhoea, vomit, and progressive weight loss. In order to make a definitive diagnosis, though, the presence of inflammatory cells infiltration must be evident on histopathologic analysis. The therapeutic approach has 2 main goals: decrease the inflammatory response and remove possible antigenic sources, such as food components or intestinal microflora...
December 29, 2017: Veterinaria Italiana
Beatriz Pineda-Rodriguez, Diana Toscano-Tejeida, Elisa García-Vences, Roxana Rodriguez-Barrera, Adrian Flores-Romero, Daniela Castellanos-Canales, Gabriel Gutierrez-Ospina, Laura Castillo-Carvajal, Esperanza Meléndez-Herrera, Antonio Ibarra
The inflammatory response is probably one of the main destructive events occurring after spinal cord injury (SCI). Its progression depends mostly on the autoimmune response developed against neural constituents. Therefore, modulation or inhibition of this self-reactive reaction could help to reduce tissue destruction. Anterior chamber associated immune deviation (ACAID) is a phenomenon that induces immune-tolerance to antigens injected into the eye´s anterior chamber, provoking the reduction of such immune response...
2017: PloS One
Orhan Gokalp, Nihan Karakas Yesilkaya, Sahin Bozok, Yuksel Besir, Hasan Iner, Huseyin Durmaz, Yasar Gokkurt, Banu Lafci, Gamze Gokalp, Levent Yilik, Ali Gurbuz
BACKGROUND: Coronary artery bypass (CAB) surgery triggers systemic inflammatory response syndrome (SIRS) via several mechanisms. Moreover, age is directly correlated with SIRS. We evaluated the effect of age on SIRS and postoperative outcome after CAB surgery. METHODS: We retrospectively reviewed the records of 229 patients who had undergone CAB surgery. The patients were divided into three groups according to age: group 1, < 40 years (n = 61); group 2, 40-75 years (n = 83); and group 3, > 75 years old (n = 85)...
January 2018: Cardiovascular Journal of Africa
Nelly T Fabre, Karina Thieme, Karolline S Silva, Sérgio Catanozi, Ana Mercedes Cavaleiro, Danilo A C Pinto, Maristela M Okamoto, Mychel Raony P T Morais, Bárbara Falquetto, Telma M Zorn, Ubiratan F Machado, Marisa Passarelli, Maria Lúcia Correa-Giannella
Because of the paucity of information regarding metabolic effects of advanced glycation end products (AGEs) on liver, we evaluated effects of AGEs chronic administration in (1) insulin sensitivity; (2) hepatic expression of genes involved in AGEs, glucose and fat metabolism, oxidative stress and inflammation and; (3) hepatic morphology and glycogen content. Rats received intraperitoneally albumin modified (AlbAGE) or not by advanced glycation for 12 weeks. AlbAGE induced whole-body insulin resistance concomitantly with increased hepatic insulin sensitivity, evidenced by activation of AKT, inactivation of GSK3, increased hepatic glycogen content, and decreased expression of gluconeogenesis genes...
May 15, 2017: Molecular and Cellular Endocrinology
Biljana Nigović, Sandra Jurić, Iva Mitrović
Nanocomposite of bismuth nanoparticles and carbon nanotubes in Nafion matrix was used as modifier for glassy carbon electrode in analysis of anti-inflamatory drug sulfasalazine. The nanocomposite surface exhibited exceptional synergy and remarkable enhancement effect to the voltammetric response of drug. The surface morphology and structure characterization of the modified electrodes was characterized by scanning electron microscopy, energy dispersive X-ray spectroscopy and cyclic voltammetry. The sensor exhibited excellent electroanalytical performance for drug determination in comparison with bismuth film electrode...
March 1, 2017: Talanta
Chakrapani Cheekavolu, M Muniappan
INTRODUCTION: The inflammatory response is closely intertwined with the process of repair. However in some diseases the inflammatory response may be exaggerated and sustained without apparent benefit and even with severe adverse complications. For decades, we have been primarily relying upon Nonsteroidal (NSAID) and Steroidal Anti-Inflammatory agents for management of various inflammatory conditions. However, adverse effects of these drugs are severe which often leads to patient's non-compliance with inadequate relief...
September 2016: Journal of Clinical and Diagnostic Research: JCDR
Marie Willems, Nadège Dubois, Lucia Musumeci, Vincent Bours, Pierre A Robe
IκBζ, an atypical member of the nuclear IκB family of proteins, is expressed at low levels in most resting cells, but is induced upon stimulation of Toll-like/IL-1 receptors through an IRAK1/IRAK4/NFκB-dependent pathway. Like its homolog Bcl3, IκBζ can regulate the transcription of a set of inflamatory genes through its association with the p50 or p52 subunits of NF-κB. Long studied as a key component of the immune response, IκBζ emerges as an important regulator of inflammation, cell proliferation and survival...
October 4, 2016: Oncotarget
T Soydas, O Karaman, H Arkan, G Yenmis, M M Ilhan, K Tombulturk, E Tasan, G Kanigur Sultuybek
Morbid obesity (MO) is associated with an increase in circulating levels of systemic acute phase proteins such as C-reactive protein (CRP). Toll-like receptor is possible candidate for inflammatory responses which is mainly mediated by NFKB1. The aim of this study was to investigate the relationship between NFKB1 and Toll-like receptor (TLR) 2 polymorphisms and the risk of MO in a Turkish population in the context of CRP serum levels which may contribute to susceptibility to the disease. We analysed the distribution of NFKB1-94 ins/del ATTG rs28362491 and TLR2 Arg753Gln rs5743708 polymorphisms using PCR-RFLP method and CRP serum levels using ELISA method in 213 MO and 200 healthy controls...
November 2016: Scandinavian Journal of Immunology
Jorge Valencia-Ortega, Arturo Zárate, Renata Saucedo, Hernández-Valencia Marcelino, José Gregorio Cruz-Durán, Edgardo Puello-Tamara, Fabián Arechavaleta-Velasco
Preeclampsia is one of the main causes of maternal and perinatal mortality in the world; however, the pathophysiologic pathways haven't been clearly elucidated. It is thought to result from a breakdown of maternal tolerance to paternal antigens in placenta that start an immune response against the trophoblast inducing a defective placentation and a hipoxic/isquemic environment which in turn triggers a systemic inflamatory response. This review gives an overview of the mechanims involved in maternal tolerance, how these are disrupted in preeclampsia, and how they contribute to the inflamatory response...
August 2015: Ginecología y Obstetricia de México
Nicole Steiner, Rachelle Balez, Niloo Karunaweera, Joanne M Lind, Gerald Münch, Lezanne Ooi
Chronic inflammation is a hallmark of neurodegenerative disease and cytotoxic levels of nitric oxide (NO) and pro-inflammatory cytokines can initiate neuronal death pathways. A range of cellular assays were used to assess the anti-inflammatory and neuroprotective action of resveratrol using murine microglial (C8-B4), macrophage (RAW264.7) and neuronal-like (Neuro2a) cell lines. We examined the release of NO by Griess assay and used a Bioplex array to measure a panel of pro- and anti-inflammatory cytokines and chemokines, in response to the inflammatory stimuli lipopolysaccharide (LPS) and interferon-γ (IFN-γ)...
May 2016: Neurochemistry International
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