Songbo Fu, Songquan Fu, Xiaoni Ma, Xiaomei Yang, Jizu Ling
Gestational diabetes mellitus (GDM) is a serious life‑threatening disease that affects the mother and fetus. However, the pathogenesis of GDM is still unclear. microRNAs (miRs) play vital roles in the regulation of various cell functions. The present study aimed to investigate the effects of miR‑875‑5p and thioredoxin reductase 1 cytoplasmic (TXNRD1) in GDM rats and analyze the associated underlying mechanism. A GDM rat model was induced using an intraperitoneal injection of streptozotocin. miR‑875‑5p knockdown plasmids or TXNRD1 knockdown plasmids were injected into the rats via the caudal vein...
May 2021: Molecular Medicine Reports
Mahmood Khaksary Mahabady, Mohammad Mehdi Shamsi, Reza Ranjbar, Mohammad Reza Tabandeh, Kaveh Khazaeel
INTRODUCTION: Gestational diabetes mellitus (GDM) is a metabolic syndrome among pregnant mothers that increases the risk of developing growth disorders in the fetus and the placenta. Adiponectin is an adipokine, which plays a central role in the regulation of glucose and lipid metabolism, energy homeostasis, and insulin resistance in various tissues. Quercetin is a natural flavonoid with beneficial effects in the diabetic animal model, but data related to its effect on histological change and adiponectin system in the placenta of GDM are limited...
February 23, 2021: Placenta
Yue Wu, Jiaxiao Yu, Xiyao Liu, Wenling Wang, Zhi Chen, Juan Qiao, Xiaohui Liu, Huili Jin, Xin Li, Li Wen, Jing Tian, Richard Saffery, Mark D Kilby, Hongbo Qi, Chao Tong, Philip N Baker
BACKGROUND: Gestational diabetes mellitus (GDM) is the most common metabolic disturbance during pregnancy and leads to an altered metabolic profile of human breast milk (HBM). The association between HBM metabolites and neonatal growth in GDM pregnancies has not been thoroughly investigated. AIMS: The primary aim was to quantify differences in the HBM metabolome between normal and GDM pregnancies. The secondary aim was to identify metabolites associated with neonatal growth during the first year postpartum...
February 16, 2021: Clinical Nutrition
Theodora Pittara, Andreas Vyrides, Demetris Lamnisos, Konstantinos Giannakou
BACKGROUND: Preeclampsia (PE) is a pregnancy-associated condition with complex disease mechanisms and a risk factor for various long-term health outcomes for the mother and infant. OBJECTIVE: To summarize evidence on the association of PE with long-term health outcomes arising in women and/or infants. SEARCH STRATEGY: PubMed, EMBASE, Scopus and ISI Web of Science were searched from inception to July 2020. SELECTION CRITERIA: Systematic reviews and meta-analyses examining associations between PE and long-term health outcomes in women and their infants...
February 27, 2021: BJOG: An International Journal of Obstetrics and Gynaecology
Michelle C Liu, Ruth Ann Bertsch
INTRODUCTION: Ketoacidosis is a metabolic condition caused by the buildup of ketone bodies. The most common causes are diabetes, alcoholism, and starvation. This is a case of a lactating mother on a ketogenic diet who developed a community-acquired pneumonia and then went into life-threatening ketoacidosis. CASE PRESENTATION: A 32-year-old, lactating, 8-week-postpartum woman presented to the hospital complaining of nausea, vomiting, rhinorrhea, and cough. She had no history of diabetes or of alcohol or drug use but reported following a ketogenic diet and was found to have a pneumonia...
January 2021: Permanente Journal
Alexandra Berezowsky, Oded Raban, Amir Aviram, Rony Chen, Arnon Wiznitzer, Eran Hadar
This is a retrospective analysis of mothers with abnormal 1-hour, 50-grams glucose challenge test (GCT) who did not take a 3-hour, 100-gram oral glucose tolerance test (OGTT). This study group of women was compared to three control groups, based on an OGTT diagnostic test- normal OGTT, single pathological value and gestational diabetes mellitus. Overall- 4,185 women were included and sub-divided accordingly into four groups: Group A-340 (8.12%)- no OGTT; Group B-2,585 (61.77%)- Norm OGTT (All values normal); Group C- 564 (13...
February 25, 2021: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
Junita Indarti, Sulaeman Andrianto Susilo, Purnomo Hyawicaksono, Jimmy Sakti Nanda Berguna, Galuh Anindya Tyagitha, Muhammad Ikhsan
Obesity is a pandemic found in many countries. It is estimated that, in 2025, more than 21% of women in the world will suffer from obesity and its number keeps increasing yearly. Obesity in pregnancy is one of the important challenges in obstetric services given the prevalence and potential adverse effects on the mother and fetus. Obese women have a higher risk of developing gestational diabetes, gestational hypertension, preeclampsia, venous thromboembolism, postpartum hemorrhage, cesarean delivery, and maternal death...
2021: Obstetrics and Gynecology International
Michelle L Katz, Tara Kaushal, Zijing Guo, Alina Cheema, Rachel Gerrard, Lori M Laffel
AIMS: Conversations about diabetes complications with adolescents and parents can be difficult and emotionally charged. To better inform conversations between providers and families, we sought adolescent and parent perspectives regarding their knowledge of long-term complications (LTCs), where they receive this information, and what they would like to learn from clinicians. METHODS: Adolescents with type 1 diabetes and parents of adolescents with type 1 diabetes participated in semistructured interviews querying knowledge of LTCs, sources of information, and preferred ways for providers to discuss LTCs...
January 2021: Diabetes Spectrum: a Publication of the American Diabetes Association
Delia Bogdanet, Mohamad Mustafa, Aftab Khattak, Paula M O' Shea, Fidelma P Dunne
BACKGROUND/OBJECTIVES: The Institute of Medicine (IOM) recommends gestational weight gain (GWG) of 5-9 kg in women with a body mass index (BMI) ≥ 30 kg/m2 . Debate continues as to whether GWG less than that recommended is safe in women with gestational diabetes mellitus (GDM). The study objective was to examine maternal and infant outcomes for obese women with GDM who lost weight or gained 0-5 kg during pregnancy. SUBJECTS/METHODS: A 7-year retrospective cohort study of pregnancy outcomes for obese women with GDM recorded in the Atlantic Diabetes in Pregnancy database was conducted...
February 24, 2021: International Journal of Obesity
Laura Räisänen, Heli Viljakainen, Catharina Sarkkola, Kaija-Leena Kolho
Type 1 diabetes mellitus (DM), autoimmune thyroiditis (AIT), juvenile idiopathic arthritis (JIA), and inflammatory bowel diseases (IBD) are common pediatric autoimmune diseases with unknown risk factors. Using nationwide registers, we searched for their perinatal risk factors. Our study followed up 11,407 children (born 2000-2005) for a median of 16.6 years (from birth to 2018). Of them, 2.15% received primary diagnosis and 0.08% also secondary: 0.89% had DM, 0.60% had AIT, 0.48% had JIA, and 0.25% had IBD...
February 23, 2021: European Journal of Pediatrics
Jami L Josefson, Denise M Scholtens, Alan Kuang, Patrick M Catalano, Lynn P Lowe, Alan R Dyer, Lucia C Petito, William L Lowe, Boyd E Metzger
OBJECTIVE: Excessive childhood adiposity is a risk factor for adverse metabolic health. The objective was to investigate associations of newborn body composition and cord C-peptide with childhood anthropometrics and explore whether these newborn measures mediate associations of maternal midpregnancy glucose and BMI with childhood adiposity. RESEARCH DESIGN AND METHODS: Data on mother/offspring pairs ( N = 4,832) from the epidemiological Hyperglycemia and Adverse Pregnancy Outcome (HAPO) Study and HAPO Follow-up Study (HAPO FUS) were analyzed...
February 22, 2021: Diabetes Care
Hye Rim Chung, Joon Ho Moon, Jung Sub Lim, Young Ah Lee, Choong Ho Shin, Joon-Seok Hong, Soo Heon Kwak, Sung Hee Choi, Hak Chul Jang
Background: The effect of intrauterine hyperglycemia on fat mass and regional fat proportion of the offspring of mothers with gestational diabetes mellitus (OGDM) remains to be determined. Methods: The body composition of OGDM (n=25) and offspring of normoglycemic mothers (n=49) was compared using dualenergy X-ray absorptiometry at age 5 years. The relationship between maternal glucose concentration during a 100 g oral glucose tolerance test (OGTT) and regional fat mass or proportion was analyzed after adjusting for maternal prepregnancy body mass index (BMI)...
February 22, 2021: Diabetes & Metabolism Journal
Nagendra Chaudhary, Shree Narayan Yadav, Suresh Kumar Kalra, Santosh Pathak, Binod Kumar Gupta, Sandeep Shrestha, Matthew Patel, Imran Satia, Steven Sadhra, Charlotte Emma Bolton, Om Prakash Kurmi
Background: Small for gestational age (SGA) is common among newborns in low-income countries like Nepal and has higher immediate mortality and morbidities. Objectives: To study the prevalence and prognostic factors of SGA babies in Western Nepal. Methods: A cross-sectional study (November 2016-October 2017) was conducted in a tertiary care hospital in Western Nepal. Socio-demographic, lifestyle factors including diet, and exposures including smoking and household air pollution in mothers who delivered newborns appropriate for gestational age (AGA), SGA and large for gestational age (LGA) were recorded...
March 2021: Health Science Reports
Ting Zhang, Wen-Rong Jiang, Yin-Yin Xia, Toby Mansell, Richard Saffery, Richard D Cannon, Jamie De Seymour, Zhen Zou, Ge Xu, Ting-Li Han, Hua Zhang, Philip N Baker
BACKGROUND & AIMS: To investigate the relationship between maternal serum fatty acid levels and gestational diabetes mellitus (GDM) subtypes across pregnancy. METHODS: A total of 680 singleton mothers enrolled in the Complex Lipids in Mothers and Babies (CLIMB) study in Chongqing, China were included. Clinical information and serum samples were collected at gestational weeks (GWs) 11-14, 22-28, and 32-34. 75 g Oral Glucose Tolerance Test (OGTT) was conducted at GW 24-28 and GDM subtypes divided into three groups using International Association of Diabetes and Pregnancy Study Group (IADPSG) guidelines criteria: elevated fasting plasma glucose (FPG group; n = 59); 1-h and/or 2-h post-load glucose (1h/2h-PG group; n = 94); combined group (FPG&1h/2h-PG group; n = 42)...
February 6, 2021: Clinical Nutrition
Naglaa Fathy Barseem, Essam Khattab, Ragab Dawood, Sally Mohamed
BACKGROUND: Gestational diabetes mellitus (GDM) shares in part pathogenic mechanisms of multiple genetic interactions. Some ofT2D susceptibility genes are encountered in association with GDM. OBJECTIVE: We aimed to investigate for GST T1, M1 and G972R IRS-I gene polymorphisms with the risk of developing GDM. PATIENTS AND METHODS: In this randomized case-control study, pregnant women with GDM were genotyped for by PCR analysis for glutathione s-transferase-T1, M1 variant polymorphisms...
February 19, 2021: Current Diabetes Reviews
Yujing Sun, Jingru Qu, Jing Wang, Ruxing Zhao, Chuan Wang, Li Chen, Xinguo Hou
Background: Mutations in human KLF11 may lead to the development of maturity-onset diabetes of the young 7 (MODY7). This occurs due to impaired insulin synthesis in the pancreas. To date, the clinical and functional characteristics of the novel KLF11 mutation c.1061G > T have not yet been reported. Methods: Whole-exon sequencing was used to screen the proband and family members with clinical suspicion of the KLF11 variant. Luciferase reporter assays were used to investigate whether the KLF11 variant binds to the insulin promoter...
2021: Journal of Diabetes Research
Marianne S Strøm, Mette C Tollånes, Allen J Wilcox, Rolv Terje Lie, Ingeborg Forthun, Dag Moster
BACKGROUND AND OBJECTIVES: Previous studies suggest that children of mothers with certain chronic conditions may be at increased risk of cerebral palsy (CP). We explored possible associations between 17 maternal chronic conditions and CP in offspring. METHODS: We conducted a prospective cohort study of Norwegian children born in 1990-2012 and surviving to 2 years of age. Information on maternal chronic conditions during pregnancy were extracted from the Medical Birth Registry of Norway (1990-2012)...
February 18, 2021: Pediatrics
Maryam Rabiei, Tahereh Soori, Amene Abiri, Zohreh Farsi, Arshia Shizarpour, Reihaneh Pirjani
BACKGROUND: Coronavirus disease 2019 (COVID-19), the global pandemic that has spread throughout the world, is caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Given the limited scientific evidence on the manifestations and potential impact of this virus on pregnancy, we decided to report this case. CASE PRESENTATION: The patient was a 38 year-old Iranian woman with a triplet pregnancy and a history of primary infertility, as well as hypothyroidism and gestational diabetes...
February 18, 2021: Journal of Medical Case Reports
L S Thomas, E Buch, Y Pillay
INTRODUCTION: Community health worker teams are potential game-changers in ensuring access to care in vulnerable communities. Who are they? What do they actually do? Can they help South Africa realize universal health coverage? As the proactive arm of the health services, community health workers teams provide household and community education, early screening, tracing and referrals for a range of health and social services. There is little local or global evidence on the household services provided by such teams, beyond specific disease-oriented activities such as for HIV and TB...
February 18, 2021: Human Resources for Health
Kristof Y Neven, Bianca Cox, Charlotte Cosemans, Wilfried Gyselaers, Joris Penders, Michelle Plusquin, Harry A Roels, Karen Vrijens, Ann Ruttens, Tim S Nawrot
BACKGROUND: The micronutrient iodine is essential for a healthy intrauterine environment and is required for optimal fetal growth and neurodevelopment. Evidence linking urinary iodine concentrations, which mainly reflects short-term iodine intake, to gestational diabetes mellitus (GDM) is inconclusive. Although the placental concentrations would better reflect the long-term gestational iodine status, no studies to date have investigated the association between the placental iodine load and the risk at GDM...
February 19, 2021: BMC Medicine
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