Junning Ma, Yin Wei, Xiaojian Zhang, Lu Lin, Youmei Bao, Hui Cao, Honghwei Chen, Jianbo Yu, Jiqi Yang, Yue Zhang, Huimin Lan, XueYang Li, Huang Qiong, Dan Yang, Yajun Yu, Jingyao Chen, Chengchen Zhang, Li Liu, Lei Chen, Renya Zhan, Fei Liu
Rapid advances in nanomedicine have enabled potential applications in cancer therapy. The enhanced permeability and retention (EPR) effect is the primary rationale for the passive targeting of nanoparticles in oncology. However, growing evidence indicates that the accumulation of nanomaterials via the EPR effect could be more efficient. Inspired by our clinical observation of the Gap Junction connecpion between folliculostellate cells and pituitary adenoma cells, we designed a novel drug delivery system that targets tumours by coating folliculostellate cell (FS) membranes onto PLGA nanoparticles (NPs)...
February 2024: Materials today. Bio