Juan Carlos Arévalo, Synphen H Wu, Takuya Takahashi, Hong Zhang, Tao Yu, Hiroko Yano, Teresa A Milner, Lino Tessarollo, Ipe Ninan, Ottavio Arancio, Moses V Chao
Activity-dependent changes of synaptic connections are facilitated by a variety of scaffold proteins, including PSD-95, Shank, SAP97 and GRIP, which serve to organize ion channels, receptors and enzymatic activities and to coordinate the actin cytoskeleton. The abundance of these scaffold proteins raises questions about the functional specificity of action of each protein. Here we report that basal synaptic transmission is regulated in an unexpected manner by the ankyrin repeat-rich membrane-spanning (ARMS/Kidins220) scaffold protein...
October 2010: Molecular and Cellular Neurosciences