Darrin J Lee, Neil M Drummond, Utpal Saha, Philippe De Vloo, Robert F Dallapiazza, Robert Gramer, Tameem M Al-Ozzi, Jordan Lam, Aaron Loh, Gavin J B Elias, Alexandre Boutet, Jurgen Germann, Mojgan Hodaie, Alfonso Fasano, Renato P Munhoz, William Hutchison, Melanie Cohn, Robert Chen, Suneil K Kalia, Andres M Lozano
BACKGROUND: Parkinson's disease (PD) is a common neurodegenerative disorder that results in movement-related dysfunction and has variable cognitive impairment. Deep brain stimulation (DBS) of the dorsal subthalamic nucleus (STN) has been shown to be effective in improving motor symptoms; however, cognitive impairment is often unchanged, and in some cases, worsened particularly on tasks of verbal fluency. Traditional DBS strategies use high frequency gamma stimulation for motor symptoms (∼130 Hz), but there is evidence that low frequency theta oscillations (5-12 Hz) are important in cognition...
April 30, 2021: Brain Stimulation