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JOURNAL ARTICLE
Neda Dolatkhah, Alireza Jafari, Fariba Eslamian, Vahideh Toopchizadeh, Parviz Saleh, Maryam Hashemian
PURPOSE: This study aimed to determine the effect of the probiotic Saccharomyces boulardii (S. boulardii) in patients with knee osteoarthritis (KOA). METHODS: In this study, 70 patients with KOA were recruited via outpatient clinics between 2020 and 2021 and randomly assigned to receive probiotics or placebo supplements for 12 weeks. The primary outcome was a change in pain intensity according to the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC) pain score...
May 18, 2024: European Journal of Nutrition
#2
RANDOMIZED CONTROLLED TRIAL
Yong-Yao Wu, Yi-Yi Gao, Jing-Qiao Wang, Chao Zhang, Peng-Jie Xu, Jiang Liu, Ri-Zhen Yu, Hao-Jie Zhang
OBJECTIVE: To study the effect of mindfulness meditation combined with progressive muscle relaxation training on the clinical efficacy and quality of life in patients with sarcopenia receiving maintenance haemodialysis (MHD). METHODS: Eligible patients with sarcopenia in our hospital were randomly assigned to a control group (n = 24) and an intervention group (n = 25). The control group received conventional dialysis treatment, while the intervention group underwent mindfulness meditation combined with progressive muscle relaxation training during the interdialysis period in addition to conventional dialysis treatment...
May 17, 2024: BMC complementary medicine and therapies
#3
JOURNAL ARTICLE
Zhouyi Wang, Zhouao Zhang, Tiancheng Luo, Xue Du, Mingjin Yang, Qian Yao, Luyao Su, Yuting Li, Xiao Chen, Xiaoyu Huang, Yong Zhang
BACKGROUND: Myasthenia gravis (MG) is an autoimmune disease mediated by pathogenic antibodies produced by abnormally activated B cells, resulting in neuromuscular junction transmission dysfunction. Interleukin-41 (IL-41) is a novel immunomodulatory cytokine that has been implicated in various metabolic, inflammatory, and autoimmune diseases. The role of IL-41 in MG is still unclear up to now, our study aimed to investigate the level of IL-41 in MG patients and its correlation with clinical features and inflammatory indicators...
May 16, 2024: International Immunopharmacology
#4
JOURNAL ARTICLE
Minmin Li, Jianjun Gao
OBJECTIVE: Mycoplasma pneumoniae (MP) infection is a common respiratory illness in children, but the factors associated with its severity remain unclear. METHODS: The clinical data of 136 children aged 5 to 12 years with MP infection in our hospital from March 2021 to March 2022 were retrospectively analyzed. According to the severity of the disease, they were divided into a mild group (74 cases) and a severe group (62 cases), and 80 healthy children who underwent physical examination in our hospital during the same period were selected as the control group...
May 17, 2024: Alternative Therapies in Health and Medicine
#5
JOURNAL ARTICLE
Aydan Kilicarslan, Kaan Yuksel, Nuran Sungu
OBJECTIVE: To compare Frozen Section (FS) results during the reimplantation stage of revision knee arthroplasty, in patients without clinical signs of infection but with preoperative inconclusive serum inflammatory markers. METHODS: Sections were revisited the day after surgery. Intraoperative FS (iFS) was accepted as positive when the presence of >5 polymorphonuclear neutrophils (PMNLs) in 5 separate high-power fields was determined according to the consensus criteria of the International Consensus on Musculoskeletal Infection...
2024: Northern Clinics of Istanbul
#6
JOURNAL ARTICLE
Lin Liu, Juanying Zhen, Shuyun Liu, Lijie Ren, Guoru Zhao, Jianguo Liang, Aimin Xu, Chao Li, Jun Wu, Bernard Man Yung Cheung
BACKGROUND: Irregular sleep patterns have been associated with inflammation. Galectin-3, a novel biomarker, plays an important role in inflammation. We investigated the relationship between sleep patterns and galectin-3 in a Chinese population. METHODS: A total of 1,058 participants from the Shenzhen-Hong Kong United Network on Cardiovascular Disease study were included in the analysis. Age and sex-adjusted linear regression models were employed to investigate the relationship between galectin-3 level and traditional metabolic biomarkers...
May 16, 2024: BMC Public Health
#7
JOURNAL ARTICLE
Cheng-Xi Li, Jing Leng, Kun Xiang
OBJECTIVE: Mounting evidence indicates that modifiable risk factors such as lifestyle behaviors may be involved in the occurrence of oral diseases. However, existing research doesn't come to a unanimous consent. This study aims to evaluate the association between lifestyle behaviors and oral health care needs. METHODS: This study used the nationally representative dataset from the National Health and Nutrition Examination Survey (NHANES) from March 2017 to 2020 pre-pandemic...
May 14, 2024: Preventive Medicine
#8
JOURNAL ARTICLE
Javier Arredondo Montero, Samuel Sáez Álvarez, Mónica Bronte Anaut, Ramiro López Medrano, María Antonia Remacha Esteras, María Rodríguez Ruiz, Francisco Miguel Izquierdo García
Although Blastocystis sp. has been classically considered a commensal parasite with limited pathogenicity, recent studies suggest that its pathogenic potential is high. We report the case of a 9-year-old Spanish male who presented with peritonitis secondary to acute appendicitis with abundant intra-abdominal turbid-free fluid. A standard appendectomy was performed, and a sample of the fluid was taken for microbiological culture. Multimicrobial flora was isolated in peritoneal fluid culture. The antibiotic resistance study showed that all the microorganisms were sensitive to meropenem...
May 10, 2024: Pediatric Infectious Disease Journal
#9
JOURNAL ARTICLE
Charbel Gharios, Mandy M T van Leent, Helena L Chang, Shady Abohashem, David O'Connor, Michael T Osborne, Cheuk Y Tang, Audrey E Kaufman, Philip M Robson, Sarayu Ramachandran, Claudia Calcagno, Venkatesh Mani, Maria Giovanna Trivieri, Antonia V Seligowski, Sharon Dekel, Willem J M Mulder, James W Murrough, Lisa M Shin, Ahmed Tawakol, Zahi A Fayad
BACKGROUND AND AIMS: Chronic stress associates with cardiovascular disease, but mechanisms remain incompletely defined. Advanced imaging was used to identify stress-related neural imaging phenotypes associated with atherosclerosis. METHODS: Twenty-seven individuals with post-traumatic stress disorder (PTSD), 45 trauma-exposed controls without PTSD, and 22 healthy controls underwent 18F-fluorodeoxyglucose positron emission tomography/magnetic resonance imaging (18F-FDG PET/MRI)...
May 16, 2024: European Heart Journal
#10
REVIEW
Mashael Al-Namaeh
OBJECTIVE: Glaucoma is the second-leading cause of blindness in the US for people over the age of 40; the most common form is primary open-angle glaucoma (POAG). It has been suggested that inflammatory markers have a role in the development and the progression of glaucoma (GL). High-sensitivity C reactive protein (HsCRP) is an inflammatory marker that has been linked to cardiovascular disease and a possible link to GL. Although a number of studies have found a link between CRP and GL; POAG, normal tension glaucoma (NTG), exfoliation glaucoma (XFG), Exfoliation syndrome (XFS), other research has shown the opposite...
May 15, 2024: European Journal of Ophthalmology
#11
JOURNAL ARTICLE
Zhangyu Lin, Jining He, Chenxi Song, Sheng Yuan, Yanjun Song, Xiaohui Bian, Kefei Dou
BACKGROUND AND AIMS: This study aimed to investigate the association of the triglyceride-glucose (TyG) index, a simple-but-reliable indicator of insulin resistance, with risk of cardiovascular (CV) events in coronary artery disease (CAD) patients with different inflammation status. METHODS AND RESULTS: We consecutively recruited 20,518 patients with angiograph-proven-CAD from 2017 to 2018 at Fuwai Hospital. Patients were categorized according to baseline TyG index tertiles (T) (tertile 1: ≤8...
April 25, 2024: Nutrition, Metabolism, and Cardiovascular Diseases: NMCD
#12
JOURNAL ARTICLE
Thomas Albrecht, Annik Rossberg, Fabian Rose, Kai Breuhahn, Eva-Marie Baumann, Marcell Tóth, Fritz Brinkmann, Alphonse Charbel, Monika Nadja Vogel, Bruno Köhler, Arianeb Mehrabi, Markus Wolfgang Büchler, Stephan Singer, Wiebke Solass, Beate Straub, Peter Schirmacher, Stephanie Roessler, Benjamin Goeppert
AIMS: Intrahepatic cholangiocarcinoma (iCCA) is a diagnosis of exclusion that can pose a challenge to the pathologist despite thorough clinical workup. Although several immunohistochemical markers have been proposed for iCCA, none of them reached clinical practice. We here assessed the combined usage of two promising diagnostic approaches, albumin in situ hybridisation (Alb-ISH) and C reactive protein (CRP) immunohistochemistry, for distinguishing iCCA from other adenocarcinoma primaries...
May 15, 2024: Journal of Clinical Pathology
#13
JOURNAL ARTICLE
Lilah M Besser, Kyle Edwards, Nina-Simone Lobban, Magdalena I Tolea, James E Galvin
BACKGROUND: Few studies have investigated associations between perceived social determinants of health (SDOH) and Alzheimer's disease and related dementia (ADRD) biomarkers or between SDOH and resilience against ADRD. OBJECTIVE: To examine associations between perceived and objective SDOH and ADRD-related outcomes. METHODS: We used cross-sectional data on≥50-year-olds without dementia in the Healthy Brain Initiative (n = 162)...
2024: JAD Reports
#14
JOURNAL ARTICLE
Saizheng Weng, Rongyan Zheng, Ruiqian Lin
OBJECTIVE: This trial analyzed high-sensitivity C-reactive protein (hs-CRP), homocysteine (Hcy), and macrophage migration inhibitory factor (MIF) level in serum and their correlation with symptom severity and cognitive function in patients with schizophrenia (SP). METHODS: Sixty-eight SP patients were enrolled in the SP group, and 68 healthy volunteers were in the control (CN) group. Serum hs-CRP, Hcy, and MIF were measured, and symptom severity was assessed with the Positive and Negative Symptom Scale (PANSS)...
May 2024: Clinical Neuropharmacology
#15
JOURNAL ARTICLE
Yali Chen, Yi Teng, Xiran Peng, Tao Zhu, Juan Liu, Mengchan Ou, Xuechao Hao
INTRODUCTION: The number of elderly patients who require surgery as their primary treatment has increased rapidly in recent years. Among 300 million people globally who underwent surgery every year, patients aged 65 years and over accounted for more than 30% of cases. Despite medical advances, older patients remain at higher risk of postoperative complications. Early diagnosis and effective prediction are essential requirements for preventing serious postoperative complications...
May 14, 2024: Advances in Therapy
#16
REVIEW
Gautam N Bedi, Sourya Acharya, Sunil Kumar, Smruti A Mapari
High-sensitivity C-reactive protein (hsCRP) has emerged as a critical biomarker in inflammation, offering insights into various chronic diseases. However, traditional blood-based assays for hsCRP measurement pose limitations regarding invasiveness and cost. In recent years, saliva has garnered attention as an alternative diagnostic medium, presenting a noninvasive and easily accessible option for biomarker analysis. Salivary hsCRP has thus emerged as a promising avenue for research and clinical application, offering potential advantages over blood-based assays...
April 2024: Curēus
#17
JOURNAL ARTICLE
I M Rabinovich, M V Snegirev, N B Petrukhina, O A Boriskina, M V Saltovets
PURPOSE OF THE STUDY: To study the effectiveness of the drug Cholisal as part of the conservative treatment of chronic periodontitis. MATERIAL AND METHODS: We selected 100 patients aged 35 to 65 years of both sexes with a diagnosis of moderate chronic periodontitis in the acute stage with a periodontal pocket depth of 3.5-5 mm. Depending on the tactics of conservative treatment of periodontitis, patients were divided into two groups of 50 people. In the main group, Cholisal dental gel was used as part of complex conservative treatment, and in the control group, Metrogil-denta gel was used...
2024: Stomatologii︠a︡
#18
JOURNAL ARTICLE
Flor A Gowans, Danny Q Thach, Zhouyang Zhu, Yangzhi Wang, Belen E Altamirano Poblano, Dustin Dovala, John A Tallarico, Jeffrey M McKenna, Markus Schirle, Thomas J Maimone, Daniel K Nomura
Ophiobolin A (OPA) is a sesterterpenoid fungal natural product with broad anticancer activity. While OPA possesses multiple electrophilic moieties that can covalently react with nucleophilic amino acids on proteins, the proteome-wide targets and mechanism of OPA remain poorly understood in many contexts. In this study, we used covalent chemoproteomic platforms to map the proteome-wide reactivity of the OPA in a highly sensitive lung cancer cell line. Among several proteins that OPA engaged, we focused on two targets: lysine-72 of cytochrome c oxidase subunit 5A (COX5A) and cysteine-53 of mitochondrial hypoxia induced gene 1 domain family member 2A (HIGD2A)...
May 13, 2024: ACS Chemical Biology
#19
JOURNAL ARTICLE
Johannes Tobias Neumann, Raphael Twerenbold, Jessica Weimann, Christie M Ballantyne, Emelia J Benjamin, Simona Costanzo, James A de Lemos, Christopher R deFilippi, Augusto Di Castelnuovo, Chiara Donfrancesco, Marcus Dörr, Kai M Eggers, Gunnar Engström, Stephan B Felix, Marco M Ferrario, Ron T Gansevoort, Simona Giampaoli, Vilmantas Giedraitis, Pär Hedberg, Licia Iacoviello, Torben Jørgensen, Frank Kee, Wolfgang Koenig, Kari Kuulasmaa, Joshua R Lewis, Thiess Lorenz, Magnus N Lyngbakken, Christina Magnussen, Olle Melander, Matthias Nauck, Teemu J Niiranen, Peter M Nilsson, Michael H Olsen, Torbjorn Omland, Viktor Oskarsson, Luigi Palmieri, Anette Peters, Richard L Prince, Vazhma Qaderi, Ramachandran S Vasan, Veikko Salomaa, Susana Sans, J Gustav Smith, Stefan Söderberg, Barbara Thorand, Andrew M Tonkin, Hugh Tunstall-Pedoe, Giovanni Veronesi, Tetsu Watanabe, Masafumi Watanabe, Andreas M Zeiher, Tanja Zeller, Stefan Blankenberg, Francisco Ojeda
IMPORTANCE: Identification of individuals at high risk for atherosclerotic cardiovascular disease within the population is important to inform primary prevention strategies. OBJECTIVE: To evaluate the prognostic value of routinely available cardiovascular biomarkers when added to established risk factors. DESIGN, SETTING, AND PARTICIPANTS: Individual-level analysis including data on cardiovascular biomarkers from 28 general population-based cohorts from 12 countries and 4 continents with assessments by participant age...
May 13, 2024: JAMA
#20
JOURNAL ARTICLE
Dong-Hyun Lee, Gyu-Min Lee, Hyung Bin Park
BACKGROUND: In rotator cuff repair, the long head of the biceps tendon (LHB) is a common graft material. However, the factors associated with LHB tear severity are poorly understood, and predicting grade II LHB tears is difficult. This study aimed to identify those factors before surgery. METHODS: The demographics, medical parameters, and pain severity of 750 patients who underwent arthroscopic surgery from January 2010 to February 2021 were evaluated to determine the factors associated with LHB tear severity and grade II LHB tears...
April 22, 2024: Clinics in shoulder and elbow
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