Jingjing Lin, Kai Chen, Wenfeng Chen, Yizhou Yao, Shiwei Ni, Meina Ye, Guifeng Zhuang, Minhuang Hu, Jun Gao, Caixi Gao, Yan Liu, Mingjuan Yang, Zhenkun Zhang, Xiaohui Zhang, Jiexiang Huang, Fei Chen, Ling Sun, Xi Zhang, Suhong Yu, Yuling Chen, Yating Jiang, Shujuan Wang, Xiaozhen Yang, Ke Liu, Hai-Meng Zhou, Zhiliang Ji, Haiteng Deng, M Emdadul Haque, Junxiang Li, Li-Zhi Mi, Yuexi Li, Yufeng Yang
Aberrant mitophagy has been implicated in a broad spectrum of disorders. PINK1, Parkin, and ubiquitin have pivotal roles in priming mitophagy. However, the entire regulatory landscape and the precise control mechanisms of mitophagy remain to be elucidated. Here, we uncover fundamental mitophagy regulation involving PINK1 and a non-canonical role of the mitochondrial Tu translation elongation factor (TUFm). The mitochondrion-cytosol dual-localized TUFm interacts with PINK1 biochemically and genetically, which is an evolutionarily conserved Parkin-independent route toward mitophagy...
October 20, 2020: Molecular Cell