Mengyuan Li, Xiangbing Kong, Xiaotong Jian, Yacong Bo, Xinyi Miao, Huaiyong Chen, Pingping Shang, Xiaolei Zhou, Ling Wang, Qiao Zhang, Qihong Deng, Yuan Xue, Feifei Feng
Ozone (O3 ) is a major air pollutant that directly threatens the respiratory system, lung fatty acid metabolism disorder is an important molecular event in pulmonary inflammatory diseases. Liver kinase B1 (LKB1) and nucleotide-binding domain leucine-rich repeat-containing protein 3 (NLRP3) inflammasome not only regulate inflammation, but also have close relationship with fatty acid metabolism. However, the role and mechanism of LKB1 and NLRP3 inflammasome in lung fatty acid metabolism, which may contribute to ozone-induced lung inflammation, remain unclear, and effective strategy for preventing O3 -induced pulmonary inflammatory injury is lacking...
May 13, 2024: Science of the Total Environment