Raihan Kabir, Prithvi Sinha, Sumita Mishra, Obialunanma V Ebenebe, Nicole Taube, Christian U Oeing, Gizem Keceli, Rui Chen, Nazareno Paolocci, Ana Maria Rule, Mark J Kohr
Arsenic exposure through drinking water is widespread and well-associated with adverse cardiovascular outcomes, yet the pathophysiological mechanisms by which inorganic arsenic (iAS) induces these effects are largely unknown. Recently, an epidemiological study in an American population with a low burden of cardiovascular risk factors found that iAS exposure was associated with altered left ventricular geometry. Considering the possibility that iAS directly induces cardiac remodeling independent of hypertension, we investigated the impact of an environmentally relevant iAS exposure on the structure and function of male and female hearts...
January 22, 2021: American Journal of Physiology. Heart and Circulatory Physiology
Xie Saiyang, Wu Qingqing, Xu Man, Liu Chen, Zhang Min, Xing Yun, Shi Wenke, Wu Haiming, Zeng Xiaofeng, Chen Si, Guo Haipeng, Deng Wei, Tang Qizhu
BACKGROUND: As a pattern recognition receptor, Toll-like receptor 7 (TLR7) widely presented in the endosomal membrane of various cells. However, the precise role and mechanism of TLR7 in septic cardiomyopathy remain unknown. This study aims to determine the role of TLR7 in cardiac dysfunction during sepsis and explore the mechanism of TLR7 in septic cardiomyopathy. METHODS: We generated a mouse model of septic cardiomyopathy by challenging with lipopolysaccharide (LPS)...
January 2021: Clinical and Translational Medicine
Romain Corroenne, Lee Wesley, Joshua A Kailin, Betul Yilmaz Furtun, Magdalena Sanz Cortes, Alireza A Shamshirsaz, Ahmed A Nassr, Michael A Belfort, Jimmy Espinoza
OBJECTIVE: To determine if inter-twin differences in fetal echocardiographic findings are associated with fetal survival in monochorionic pregnancies complicated by twin-to-twin transfusion syndrome (TTTS). METHODS: This study included women who underwent laser surgery for TTTS between 2012 and 2018 at a single institution. Echocardiographic cardiac parameters in the donor and recipient twins were compared using Z -scores and regression analyses (adjusted for confounding variables) to determine whether any measurable inter-twin differences were associated with neonatal survival at birth...
January 17, 2021: Journal of Maternal-fetal & Neonatal Medicine
Ron Bardin, Sharon Perlman, Eran Hadar, Yael Mozer Glassberg, Elchanan Bruckheimer, Michal Silber, Yinon Gilboa
OBJECTIVES: Congenital portosystemic shunt (CPSS) in a growth-restricted fetus may lead to cardiac overload and ultimately hemodynamic imbalance. The aim of the study was to describe the application of tricuspid annular plane systolic excursion (TAPSE) for surveillance of cardiac function in growth-restricted fetuses diagnosed with CPSS. METHODS: The study group consisted of 7 fetuses with growth restriction diagnosed with CPSS between 2018 and 2020. Patients were followed longitudinally every 2 weeks...
January 11, 2021: Journal of Ultrasound in Medicine: Official Journal of the American Institute of Ultrasound in Medicine
Andrew Porter, Sunkyung Yu, Ray Lowery, Carlen G Fifer, Jimmy C Lu
BACKGROUND: The Ross operation is an important option for children with critical aortic stenosis (CAS) with residual disease, but operation in infancy is associated with significant morbidity and mortality. We evaluated echocardiographic correlates of transplant-free survival, re-intervention, and left ventricular (LV) function in mid-term follow-up. METHODS: This retrospective, single-center study included all infants with CAS who underwent Ross by 1 year of age from 1/2000 to 9/2018...
December 29, 2020: Journal of the American Society of Echocardiography
Ishan Kumar, Shweta Singh, Ashok Kumar, Priyanka Aggarwal, Ram C Shukla, Ashish Verma
AIMS AND OBJECTIVES: To evaluate the Doppler changes in the intracranial arteries of neonates exposed to perinatal hypoxic insult and compare it with normal neonates. MATERIALS AND METHODS: Color Doppler of bilateral anterior and middle cerebral arteries was performed within 6 h of birth in 26 healthy neonates and 50 neonates who received delivery room resuscitation (DRR) for perinatal depression and had a 5 min Apgar score <7. Comparisons of resistive index (RI) and peak systolic velocity (PSV) were made between the (a) control group (b) patients with low 5 min Apgar score <7 who without clinical features of neonatal encephalopathy at 24 h (c) neonates with perinatal depression with a clinical evidence of disturbed neurological function at 24 h of birth and examination consistent with mild, moderate, or severe encephalopathy using modified Sarnat and Sarnat's classification...
December 9, 2020: Journal of Perinatology: Official Journal of the California Perinatal Association
Dalia Ayoub, Abdelrahman Elmashad, Mohamed Rowisha, Mohamed Eltomey, Doaa El Amrousy
BACKGROUND: High-frequency oscillatory ventilation (HFOV) can have negative hemodynamic effects in neonates. We aimed to assess systemic, cerebral, and cardiac hemodynamic changes in preterm neonates with respiratory distress syndrome (RDS) on HFOV. METHODS: This observational study was conducted from June 2017 until May 2019 on 100 preterm neonates with RDS that needed switching from conventional mechanical ventilation to HFOV. Initial and Follow up capillary blood gas, echocardiographic examination, cranial ultrasound, and Doppler study of cerebral, celiac, superior mesenteric, and renal arteries using resistive index (RI) were performed before, 24 hours, and 72 hours after use of HFOV...
December 2, 2020: Pediatric Pulmonology
Achyut Raj Pandey, Binaya Chalise, Niraj Shrestha, Biwesh Ojha, Jasmine Maskey, Dikshya Sharma, Peter Godwin, Krishna Kumar Aryal
BACKGROUND: Between 1990 and 2017, Nepal experienced a shift in the burden of disease from communicable, maternal, neonatal and nutritional (CMNN) diseases to non-communicable diseases (NCDs). With an increasing ageing population and life-style changes including tobacco use, harmful alcohol consumption, unhealthy diets, and insufficient physical activity, the proportion of total deaths from NCDs will continue to increase. An analysis of current diseases pattern and projections of the trends informs planning of health interventions...
2020: PloS One
Filippo Sanfilippo, Valeria La Rosa, Chiara Grasso, Cristina Santonocito, Carmelo Minardi, Francesco Oliveri, Roberta Iacobelli, Marinella Astuto
OBJECTIVE: We conducted a systematic review and meta-analysis to investigate the prognostic value of echocardiographic parameters in pediatric septic patients. DATA SOURCES: MEDLINE, PubMed, and EMBASE (last update April 5, 2020). STUDY SELECTION: Observational studies of pediatric sepsis providing echocardiographic parameters in relation to mortality. DATA EXTRACTION: Echocardiography data were categorized as those describing left ventricular systolic or diastolic function, right ventricular function, and strain echocardiography parameters...
December 2, 2020: Pediatric Critical Care Medicine
D F Lu, Y F Liu, X M Tong, H Zhang, S Shi, Y H Zhang
Objective: To establish reference ranges for M-mode echocardiography in preterm infants within 7 days after birth based on different gestational age (GA) and birth weight. Methods: This retrospective study analyzed M-mode echocardiographic values of 489 premature infants, who were admitted to the neonatal intensive care unit of Department of Pediatrics, Peking University Third Hospital from March 2017 to February 2020. These infants were divided into four groups according to GA:<28 weeks, 28-31+6 weeks, 32-33+6 weeks and 34-36+6 weeks; and five groups according to birth weight:<1 000 g, 1 000-1 499 g, 1 500-1 999 g, 2 000-2 499 g and ≥2 500 g...
December 2, 2020: Zhonghua Er Ke za Zhi. Chinese Journal of Pediatrics
María G Majdalani, Estela C Falconi, Carlos J Diaz, David Doiny, Mauricio S Abello, José M Moltedo
Ventricular dysfunction secondary to electrical and mechanical dyssynchrony in chronic right ventricular apical pacing is a well-recognized complication. There are no previous reports of pharmacologically induced dyssynchrony. A 10-day old infant with incessant supraventricular tachycardia was admitted to the neonatal intensive care unit. Therapy with oral propranolol was initiated and due to persistence of tachycardia intravenous amiodarone was administered. The patient remained predominantly in tachycardia with heart rates between 200-290 beats per minute for a week with serial echocardiograms showing preserved ventricular function...
2020: Medicina
Anthony Azakie, John P Carney, Matthew T Lahti, Richard W Bianco, Michelle J Doyle, Rajat Kalra, Cindy M Martin
There are no reports on the performance of the arterial switch operation (ASO) in a normal heart with normally related great vessels. The objective of this study was to determine whether the ASO could be performed in a healthy animal model. Cardiopulmonary bypass (CPB) and coronary translocation techniques were used to perform ASO in neonatal piglets or a staged ASO with prior main pulmonary artery (PA) banding. Primary ASO was performed in four neonatal piglets. Coronary translocation was effective with angiograms confirming patency...
November 30, 2020: Pediatric Cardiology
Ryan C Fries, Stuart C Clark-Price, Saki Kadotani, Jonathan P Stack, David J Schaeffer, Kara M Lascola
OBJECTIVE: To compare measurements of left ventricular volume and function derived from 2-D transthoracic echocardiography (2DE), transesophageal echocardiography (TEE), and the ultrasound velocity dilution cardiac output method (UDCO) with those derived from cardiac MRI (cMRI) in healthy neonatal foals. ANIMALS: 6 healthy 1-week-old Standardbred foals. PROCEDURES: Foals were anesthetized and underwent 2DE, TEE, and cMRI; UDCO was performed simultaneously with 2DE...
December 2020: American Journal of Veterinary Research
Hannes Sallmon, Felix Berger, Sven C Weber, Hendrik S Fischer, Georg Hansmann, Bernd Opgen-Rhein
Reverse Potts shunt is a palliative procedure aimed at decompressing the pressure-overloaded right ventricle in severe pulmonary hypertension (PH). We, herein, report the first case of an interventional creation of an "endogenous" reverse Potts shunt by stenting a pre-existing small but patent ductus arteriosus (PDA) in a 2 months old female infant with severe, supra-systemic PH, associated with a novel combination of a compound heterozygous ABCA3 mutation and additional heterozygous genetic variants of surfactant protein B ( SFTPB ) and C ( SFTPC )...
October 2020: Cardiovascular Diagnosis and Therapy
Mefkure Eraslan Sahin, Erdem Sahin, Ilknur Col Madendag, Yusuf Madendag, Gokhan Acmaz, Fatma Ozdemir, Mehmet Mete Kırlangıç, Iptisam Ipek Muderris
OBJECTIVE: The ductus venosus, a small blood vessel in the fetal venous system, has extraordinary physiologic significance because it connects the umbilical vein to the inferior vena cava in the fetus circulation system and transports highly oxygenated blood from the placenta to the fetus' heart. Hence, assessment of ductus venosus flows is helpful in evaluating fetal hemodynamics. Considering the critical function of the ductus venosus, we hypothesized that the diameter of the midtrimester ductus venosus and its peak velocity index can be related to adequate fetal growth; therefore, the aim of this study was to evaluate the role of the midtrimester umbilical venous blood flow, ductus venosus diameter, and ductus venosus peak systolic velocity to help predict uncomplicated deliveries of late onset small for gestational age (SGA) fetuses...
November 15, 2020: Journal of Maternal-fetal & Neonatal Medicine
Vladiana Turi, Stela Iurciuc, Octavian Marius Crețu, Delia Mirela Tit, Simona Bungau, Adrian Apostol, Radu Dumitru Moleriu, Cristiana Bustea, Tapan Behl, Camelia Cristina Diaconu, Izabella Petre
AIMS: Hypertension (HTN) in pregnancy is a major cause of maternal, foetal and neonatal morbimortality in both developing and developed countries. Arterial stiffness is a predictor of cardiovascular events and can be assessed through augmentation index (AIx) and pulse wave velocity (PWV). This study was intended to analyse the arterial stiffness in three categories, hypertensive pregnant women vs. healthy women (both pregnant and non-pregnant). MAIN METHODS: Between 2018 and 2019, 150 women were prospectively included into three homogenous groups, of equal sizes (N = 50): pregnant women with HTN (group 1), pregnant women without HTN (group 2), and non-pregnant women (group 3)...
November 5, 2020: Life Sciences
Juan S Farias, Enrique G Villarreal, Saul Flores, Christopher W Mastropietro, Maggie Vogel, Kelci Schulz, Corissa Culichia, Ilias D Iliopoulos, Ronald A Bronicki, Rohit S Loomba
Vasopressin has been used to augment blood pressure; however, cardiovascular effects after cardiac surgery have not been well established. The primary objective of this study was to survey the current literature and quantify the pooled effect of vasopressin on hemodynamic parameters in children after pediatric cardiac surgery. A systematic review was conducted to identify studies characterizing the hemodynamic effects of vasopressin after pediatric cardiac surgery. Studies were assessed and those of satisfactory quality with pre- and post-vasopressin hemodynamics for each patient were included in the final analyses...
November 5, 2020: Pediatric Cardiology
Worlanyo Tashie, Linda Ahenkorah Fondjo, William K B A Owiredu, Richard K D Ephraim, Listowell Asare, Enoch Appiah Adu-Gyamfi, Laila Seidu
Background: Preeclampsia is a major cause of maternal and neonatal morbidity and mortality in sub-Saharan Africa. Evidence indicates that endothelial dysfunction is central to the pathogenesis of preeclampsia. This study assessed the level of the components of the arginine-nitric oxide pathway to evaluate endothelial dysfunction in normotensive pregnancies and pregnancies complicated with preeclampsia. Methods: This case-control study was conducted among pregnant women who visited Comboni Hospital from January 2017 to May 2018...
2020: BioMed Research International
Liron Borenstein-Levin, Amir Kugelman, Ashraf Horani, Yasmin Sharif, Amal Sharif-Rasslan, Arieh Riskin, Ori Hochwald, Gil Dinur, Annat Amshalom, David Bader, Dawod Sharif
OBJECTIVES: Phototherapy has been reported to reduce coronary blood flow in neonates but without affecting gross measures of cardiac function. The aim of our current study was to evaluate earlier, more sensitive changes in cardiac function during phototherapy. METHODS: Nineteen neonates with jaundice treated with phototherapy had Doppler echocardiographic evaluation, before, during and after phototherapy and were compared to 25 matched controls. Sensitive measures for cardiac performance in this study included left ventricular dimension, ventricular Doppler parameters and regional function assessment...
October 2020: Harefuah
Rihab Bouchareb, Michael Katz, Najla Saadallah, Yassine Sassi, Shakir Ali, Djamel Lebeche
Myocardial fibrosis is a major determinant of clinical outcomes in heart failure (HF) patients. It is characterized by the emergence of myofibroblasts and early activation of pro-fibrotic signaling pathways before adverse ventricular remodeling and progression of HF. Boron has been reported in recent years to augment the innate immune system and cell proliferation, which play an important role in the repair and regeneration of the injured tissue. Currently, the effect of boron on cardiac contractility and remodeling is unknown...
October 13, 2020: Scientific Reports
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