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MULTICENTER STUDY
Adnaldo da Silveira Maia, Dayara Hoffmann Mayer, Renê Augusto Gonçalves E Silva, Andresa Fernandes Pérego, Pedro Esteban Ulloa Alvarado, Oscar Harold Torrico Lizarraga, Mercy Adriana Herrera Arcos, Matheus da Silveira Maia, Magaly Arrais Dos Santos, Omar Asdrubal Vilca Mejia
INTRODUCTION: Atrial fibrillation is the main complication in the postoperative period of cardiovascular surgery. Its genesis is multifactorial, so its rapid identification to mitigate the associated risks is essential. OBJECTIVE: To evaluate the incidence of atrial fibrillation in patients undergoing coronary artery bypass grafting (CABG) and its relationship with other complications in our setting. METHODS: This is a multicenter, observational study involving patients undergoing isolated CABG between 2017 and 2019 with data from the Registro Paulista de Cirurgia Cardiovascular (or REPLICCAR II)...
May 15, 2024: Brazilian Journal of Cardiovascular Surgery
#42
JOURNAL ARTICLE
Qirui Guo, Hui Lian, Guangjian Wang, Hongmin Zhang, Xiaoting Wang
Background: The peripheral perfusion index (PI) reflects microcirculatory blood flow perfusion and indicates the severity and prognosis of sepsis. Method: The cohort comprised 208 patients admitted to the intensive care unit (ICU) with infection, among which 117 had sepsis. Demographics, medication history, ICU variables, and laboratory indexes were collected. Primary endpoints were in-hospital mortality and 28-day mortality. Secondary endpoints included organ function variables (coagulation function, liver function, renal function, and myocardial injury), lactate concentration, mechanical ventilation time, and length of ICU stay...
May 15, 2024: Journal of Intensive Care Medicine
#43
JOURNAL ARTICLE
Swantje Nickelsen, Eleonore Grosse Darrelmann, Lea Seidlmayer, Katrin Fink, Simone Britsch, Daniel Duerschmied, Ruediger E Scharf, Albrecht Elsaesser, Thomas Helbing
AIM: Out-of-hospital cardiac arrest (OHCA) is a major health concern in Western societies. Poor outcome after OHCA is determined by the extent of hypoxic-ischemic encephalopathy (HIE). Dysregulation of iron metabolism has prognostic relevance in patients with ischemic stroke and sepsis. The aim of this study was to determine whether serum iron parameters help to estimate outcomes after OHCA. METHODS: In this prospective single-center study, 70 adult OHCA patients were analyzed...
May 15, 2024: Journal of Intensive Care Medicine
#44
JOURNAL ARTICLE
Aling Tang, Yi Shi, Qingqing Dong, Sihui Wang, Yao Ge, Chenyan Wang, Zhimin Gong, Weizhen Zhang, Wei Chen
Objectives: To investigate the relationship between sublingual microcirculation and the prognosis of sepsis. Data sources: The PubMed, Web of Science, Embase, and China National Knowledge Infrastructure (CNKI) databases were searched to identify studies published from January 2003 to November 2023. Study selection: Clinical studies examining sublingual microcirculation and the prognosis of sepsis were included. Data extraction: Sublingual microcirculation indices included the microvascular blood index (MFI), total vascular density (TVD), perfusion vascular density (PVD), perfusion vascular vessel (PPV), and heterogeneity index (HI)...
May 15, 2024: Journal of Intensive Care Medicine
#45
JOURNAL ARTICLE
Jérome Morel, Anne Sophie Pignard, Josiane Castells, Valentine Allibert, Lahcène Hatimi, Benjamin Buhot, Mathias Velarde, Anne Cécile Durieux, Damien Freyssenet
Loss of muscle mass and function induced by sepsis contributes to physical inactivity and disability in intensive care unit patients. Limiting skeletal muscle deconditioning may thus be helpful in reducing the long-term effect of muscle wasting in patients. We tested the hypothesis that invalidation of the myostatin gene, which encodes a powerful negative regulator of skeletal muscle mass, could prevent or attenuate skeletal muscle wasting and improve survival of septic mice. Sepsis was induced by caecal ligature and puncture (CLP) in 13-week-old C57BL/6J wild-type and myostatin knock-out male mice...
May 15, 2024: Journal of Physiology
#46
JOURNAL ARTICLE
Yong-Bing Zhu, Tong-Lin Liu, Qi Dai, Shu-Fan Liu, Peng Xiong, Hao Huang, Yi Yuan, Tian-Nan Zhang, Yu Chen
OBJECTIVE: Sepsis is considered a major cause of health loss in children and had high mortality and morbidity. Currently, there is no reliable model for predicting the prognosis of pediatric patients with sepsis. This study aimed to analyze the clinical characteristics of sepsis in children and assess the risk factors associated with poor prognosis in pediatric sepsis patients to identify timely interventions and improve their outcomes. METHODS: This study analyzed the clinical indicators and laboratory results of septic patients hospitalized in the Pediatric Intensive Care Unit of Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, China, from January 1, 2019, to December 31, 2021...
May 15, 2024: Current Medical Science
#47
REVIEW
Antoine Lafarge, Dara Chean, Livia Whiting, Raphaël Clere-Jehl
Hematological malignancies may require rapid-onset treatment because of their short doubling time, notably observed in acute leukemias and specific high-grade lymphomas. Furthermore, in targeted onco-hematological scenarios, chemotherapy is deemed necessary as an emergency measure when facing short-term, life-threatening complications associated with highly chemosensitive hematological malignancies. The risks inherent in the disease itself, or in the initiation of treatment, may then require admission to the intensive care unit (ICU) to optimize monitoring and initial management protocols...
May 15, 2024: Intensive Care Medicine
#48
JOURNAL ARTICLE
Pinar Yazici Özkaya, Gülizar Koç, İrem Ersayoğlu, Kübra Cebeci, Hamiyet Hekimci Özdemir, Nihal Karadas, Deniz Yilmaz Karapinar, Bülent Karapinar
INTRODUCTION: Therapeutic plasma exchange (TPE) is used in a wide spectrum of diseases in critically ill pediatric patients. We aim to review the indications, complications, safety, and outcomes of critically ill children who received TPE. METHODS: All of the TPE procedures performed in a pediatric intensive care unit providing tertiary care during 19 years (January 2013-January 2023) were evaluated retrospectively. A total of 154 patients underwent 486 TPE sessions...
May 15, 2024: Therapeutic Apheresis and Dialysis
#49
REVIEW
Rakesh K Jagdish, Preetam Chappity, S Lata
The assessment of dental and ear, nose and throat (ENT) conditions holds significant importance in the pre-transplantation evaluation for individuals undergoing liver transplantation. This evaluation aims to address concerns related to dental and ENT issues both before and after liver transplantation. These concerns include the risk of sepsis, the impact of post-transplantation immunosuppression, the detection of existing malignancies, including oral potentially malignant disorders (OPMDs), and identifying any contraindications to the transplantation procedure...
2024: Journal of Clinical and Experimental Hepatology
#50
JOURNAL ARTICLE
Kunping Cui, Yi Mao, Shuang Feng, Haixia Luo, Jiao Yang, Ruyi Xu, Lang Bai
PURPOSE: Age is considered a vital factor in intensive care units (ICUs) because of its association with physiological frailty, comorbidities, and immune system function. Previous studies have examined the association between age and prognosis in patients with tuberculosis (TB) or sepsis; however, the association between age and prognosis in ICU patients with TB complicated by sepsis is rare. This study aimed to assess the association between age and the prognosis of patients in the ICU with TB complicated by sepsis...
2024: Infection and Drug Resistance
#51
JOURNAL ARTICLE
Bruno Evrard, Pratik Sinha, Kevin Delucchi, Carolyn M Hendrickson, Kirsten N Kangelaris, Kathleen D Liu, Andrew Willmore, Nelson Wu, Lucile Neyton, Emma Schmiege, Antonio Gomez, V Eric Kerchberger, Ann Zalucky, Michael A Matthay, Lorraine B Ware, Carolyn S Calfee
BACKGROUND: Hypoinflammatory and hyperinflammatory phenotypes have been identified in both Acute Respiratory Distress Syndrome (ARDS) and sepsis. Attributable mortality of ARDS in each phenotype of sepsis is yet to be determined. We aimed to estimate the population attributable fraction of death from ARDS (PAFARDS ) in hypoinflammatory and hyperinflammatory sepsis, and to determine the primary cause of death within each phenotype. METHODS: We studied 1737 patients with sepsis from two prospective cohorts...
May 14, 2024: Critical Care: the Official Journal of the Critical Care Forum
#52
JOURNAL ARTICLE
Rui Liu, Ningyuan Liu, Shanlian Suo, Qinfeng Yang, Zhen Deng, Wei Fu, Min Wang
BACKGROUND: Postoperative delirium (POD) is a common complication after major surgery and can cause a variety of adverse effects. However, no large-scale national database was used to assess the occurrence and factors associated with postoperative delirium (POD) following hepatic resection. METHODS: Patients who underwent hepatic resection from 2015 to 2019 were screened using the International Classification of Diseases (ICD) 10th edition clinical modification code from the National Inpatient Sample (NIS) Database...
May 14, 2024: BMC Surgery
#53
REVIEW
Pompeo Costantino Kouroupis, Niall O'Rourke, Sinead Kelly, Myles McKittrick, Elne Noppe, Luis F Reyes, Alejandro Rodriguez, Ignacio Martin-Loeches
INTRODUCTION: Hospital-acquired pneumonia (HAP) represents a significant cause of mortality among critically ill patients admitted to Intensive Care Units (ICUs). Timely and precise diagnosis is imperative to enhance therapeutic efficacy and patient outcomes. However, the diagnostic process is challenged by test limitations and a wide-ranging list of differential diagnoses, particularly in patients exhibiting escalating oxygen requirements, leukocytosis, and increased secretions. AREAS COVERED: This narrative review aims to update diagnostic modalities, facilitating the prompt identification of nosocomial pneumonia while guiding, developing, and assessing therapeutic interventions...
May 14, 2024: Expert Review of Anti-infective Therapy
#54
JOURNAL ARTICLE
Carlo Giulioni, Demetra Fuligni, Carlo Brocca, Deepak Ragoori, Ben Chew Chew, Esteban Emiliani, Chin Tiong Heng, Yiloren Tanidir, Nariman Gadzhiev, Abhishek Singh, Saeed Bin Hamri, Boyke Soehabali, Andrea Benedetto Galosi, Thomas Tailly, Olivier Traxer, Bhaskar Kumar Somani, Marcelo L Wroclawski, Vineet Gauhar, Daniele Castellani
PURPOSE: To assess the incidence of the most common intra- and early postoperative complications following RIRS in a large series of patients with kidney stones. METHODS: We conducted a retrospective analysis of patients with kidney stones who underwent RIRS across 21 centers from January 2018 to August 2021, as part of the Global Multicenter Flexible Ureteroscopy Outcome (FLEXOR) Registry. RESULTS: Among 6669 patients undergoing RIRS, 4.5% experienced intraoperative pelvicalyceal system bleeding without necessitating blood transfusion...
May 20, 2024: International Braz J Urol: Official Journal of the Brazilian Society of Urology
#55
JOURNAL ARTICLE
Timothy W Jones, Tanner Hendrick, Aaron M Chase
DISCLAIMER: In an effort to expedite the publication of articles, AJHP is posting manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. PURPOSE: To familiarize clinicians with the emerging concepts in critical care research of Bayesian thinking and personalized medicine through phenotyping and explain their clinical relevance by highlighting how they address the issues of frequent negative trials and heterogeneity of treatment effect...
May 14, 2024: American Journal of Health-system Pharmacy: AJHP
#56
JOURNAL ARTICLE
Mpho G Chipu, Irene Kearns, Mantji J Modula
BACKGROUND AND AIMS: Enterocutaneous fistula is a severe complication of an open abdomen, which poses devastating challenges for critical care nurses. The study aimed to explore and describe the challenges faced by critical care nurses caring for patients with enterocutaneous fistulas in a tertiary public hospital in Gauteng, South Africa. METHODS: A qualitative, exploratory, descriptive, and contextual design was conducted to understand the challenges experienced by the critical care nurses caring for patients with enterocutaneous fistulas...
May 2024: Health Science Reports
#57
Yasir A Lone, Santosh K Singh, Aisha Naaz, Chinmay Chetan, Shalvika V Kashyap
The main aim of this article is to highlight the clinical features indicating gastric perforation in neonates so that prompt surgery can provide a good outcome for an otherwise fatal condition. Data was collected retrospectively from all neonates who presented to our tertiary care institute with subsequent diagnosis of gastric perforation from January 2020 to December 2023 (three years). Simple statistical analysis involving sums, means, averages, and percentages was used. Five neonates were operated over a period of three years with a diagnosis of gastric perforation...
April 2024: Curēus
#58
REVIEW
Turki Alhumam, Aminah A Alhumam, Ibrahim Alhumaidi, Ibrahim Al Rajeh, Yousef Alduhailan
Symmetrical peripheral gangrene (SPG) is a rare yet severe condition characterized by peripheral ischemic lesions without significant vascular occlusion. Its clinical presentation includes peripheral cyanosis, mottling, and symmetrical ischemia of distal limbs, often progressing to gangrene. Recent years have seen a rise in SPG cases, with mortality rates ranging from 40% to 90%. The condition is associated with systemic diseases, such as sepsis, vasculitis, and coagulopathy. DIC frequently complicates SPG, reflecting a disturbed procoagulant-anticoagulant balance and depletion of natural anticoagulants...
April 2024: Curēus
#59
MULTICENTER STUDY
Paweł Melchior Pasieka, Michał Kurek, Wojciech Skupnik, Evan Skwara, Valentyn Bezshapkin, Jakub Fronczek, Anna Kluzik, Bartosz Kudliński, Szymon Białka, Dorota Studzińska, Łukasz Krzych, Szymon Czajka, Jan Stefaniak, Radosław Owczuk, Joanna Sołek-Pastuszka, Jowita Biernawska, Joanna Zorska, Paweł Krawczyk, Katarzyna Cwyl, Maciej Żukowski, Katarzyna Kotfis, Małgorzata Zegan-Barańska, Agnieszka Wieczorek, Wojciech Mudyna, Mariusz Piechota, Szymon Bernas, Waldemar Machała, Łukasz Sadowski, Marta Serwa, Mirosław Czuczwar, Michał Borys, Mirosław Ziętkiewicz, Natalia Kozera, Barbara Adamik, Waldemar Goździk, Paweł Nasiłowski, Paweł Zatorski, Janusz Trzebicki, Piotr Gałkin, Ryszard Gawda, Urszula Kościuczuk, Waldemar Cyrankiewicz, Katarzyna Sierakowska, Wojciech Gola, Hubert Hymczak, Hans Flaatten, Wojciech Szczeklik
INTRODUCTION: Elderly patients pose a significant challenge to intensive care unit (ICU) clinicians. In this study we attempted to characterise the population of patients over 80 years old admitted to ICUs in Poland and identify associations between clinical features and short-term outcomes. MATERIAL AND METHODS: The study is a post-hoc analysis of the Polish cohort of the VIP2 European prospective observational study enrolling patients > 80 years old admitted to ICUs over a 6-month period...
2024: Anaesthesiology Intensive Therapy
#60
JOURNAL ARTICLE
Julie Guérin Benz, Giovanna Stancanelli, Monica Zambruni, Manjary Ramasy Paulin, Habéline Hantavololona, Vonimboahangy Rachel Andrianarisoa, Harolalaina Rakotondrazanany, Begoña Martinez de Tejada Weber, Flavia Rosa Mangeret, Michael R Reich, Anya Guyer, Caroline Benski
BACKGROUND: The rates of maternal and neonatal deaths in Madagascar are among the highest in the world. In response to a request for additional training from obstetrical care providers at the Ambanja district hospital in north-eastern Madagascar, a partnership of institutions in Switzerland and Madagascar conducted innovative training on respectful emergency obstetric and newborn care using e-learning and simulation methodologies. The training focused on six topics: pre-eclampsia, physiological childbirth, obstetric maneuvers, postpartum hemorrhage, maternal sepsis, and newborn resuscitation...
May 13, 2024: Advances in Simulation
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