Omonigho M Bubu, Ogie Q Umasabor-Bubu, Arlener D Turner, Ankit Parekh, Anna E Mullins, Korey Kam, Madeline K Birckbichler, Fahad Mukhtar, Alfred K Mbah, Natasha J Williams, David M Rapoport, Mony de Leon, Girardin Jean-Louis, Indu Ayappa, Andrew W Varga, Ricardo S Osorio
INTRODUCTION: Obstructive sleep apnea (OSA) is associated with Alzheimer's disease (AD) biomarkers in cognitively normal (CN) and mild cognitive impaired (MCI) participants. However, independent and combined effects of OSA, amyloid beta (Aβ) and tau-accumulation on AD time-dependent progression risk is unclear. METHODS: Study participants grouped by biomarker profile, as described by the A/T/N scheme, where "A" refers to aggregated Aβ, "T" aggregated tau, and "N" to neurodegeneration, included 258 CN (OSA-positive [OSA+] [A+TN+ n = 10, A+/TN- n = 6, A-/TN+ n = 10, A-/TN- n = 6 and OSA-negative [OSA-] [A+TN+ n = 84, A+/TN- n = 11, A-/TN+ n = 96, A-/TN- n = 36]) and 785 MCI (OSA+ [A+TN+ n = 35, A+/TN- n = 15, A-/TN+ n = 25, A-/TN- n = 16] and OSA- [A+TN+ n = 388, A+/TN- n = 28, A-/TN+ n = 164, A-/TN- n = 114]) older-adults from the Alzheimer's Disease Neuroimaging Initiative cohort...
October 8, 2020: Alzheimer's & Dementia: the Journal of the Alzheimer's Association