keyword
https://read.qxmd.com/read/36841797/maternal-separation-and-tnbs-induced-gut-inflammation-synergistically-alter-the-sexually-differentiated-stress-response-in-rats
#41
JOURNAL ARTICLE
Ryoko Hasegawa, Kumi Saito-Nakaya, Li Gu, Motoyori Kanazawa, Shin Fukudo
BACKGROUND: Neonatal maternal separation (MS) has been used to model long-lasting changes in behavior caused by neuroplastic changes associated with exposure to early-life stress. Earlier studies showed that transient gut inflammation can influence the development of irritable bowel syndrome (IBS). A prevailing paradigm of the etiology of IBS is that transient noxious events lead to long-lasting sensitization of the neural pain circuit, despite complete resolution of the initiating event...
February 25, 2023: BioPsychoSocial Medicine
https://read.qxmd.com/read/36831796/auricular-vagus-nerve-stimulation-improves-visceral-hypersensitivity-and-gastric-motility-and-depression-like-behaviors-via-vago-vagal-pathway-in-a-rat-model-of-functional-dyspepsia
#42
JOURNAL ARTICLE
Liwei Hou, Peijing Rong, Yang Yang, Jiliang Fang, Junying Wang, Yu Wang, Jinling Zhang, Shuai Zhang, Zixuan Zhang, Jiande D Z Chen, Wei Wei
UNLABELLED: Transcutaneous auricular vagus nerve stimulation was recently reported to have a therapeutic potential for functional dyspepsia (FD). This study aimed to explore the integrative effects and mechanisms of auricular vagus nerve stimulation (aVNS) in a rodent model of FD. METHODS: We evaluated the effects of aVNS on visceral hypersensitivity, gastric motility and open field test (OFT) activity in iodoacetamide (IA)-treated rats. The autonomic function was assessed; blood samples and tissues were collected and analyzed by an enzyme-linked immunosorbent assay and western blot...
February 1, 2023: Brain Sciences
https://read.qxmd.com/read/36791924/traditional-chinese-medicine-decoctions-and-chinese-patent-medicines-for-the-treatment-of-depression-efficacies-and-mechanisms
#43
REVIEW
Wei Zhuang, Shao-Li Liu, Sheng-Yan Xi, Ying-Nan Feng, Ke Wang, Teliebald Abduwali, Ping Liu, Xiao-Jiang Zhou, Lan Zhang, Xian-Zhe Dong
ETHNOPHARMACOLOGICAL RELEVANCE: Depression is a major mental disorder and it is currently recognized as the second-leading cause of disability worldwide. However, the therapeutic effect of antidepressants remains unsatisfactory. Traditional Chinese medicine (TCM) has been widely used for centuries, including commonly-used complementary and alternative medical therapies for depression. Recent clinical trials have been carried out to assess the efficacy and safety of TCM, and to explore the mechanisms of action in relation to the treatment of depression...
February 13, 2023: Journal of Ethnopharmacology
https://read.qxmd.com/read/36781714/pcsk9-inhibition-reduces-depressive-like-behavior-in-cums-exposed-rats-highlights-on-hmgb1-rage-tlr4-pathway-nlrp3-inflammasome-complex-and-ido-1
#44
JOURNAL ARTICLE
Nevien Hendawy, Tala H Salaheldin, Sally A Abuelezz
Ample evidence has pointed to a close link between cardiovascular diseases (CVD) and depression. Inflammatory pathways including the high-mobility-group-box-1 protein, receptor-for-advanced-glycation-end-products and toll-like-receptor-4 (HMGB1/RAGE/TLR4) and nucleotide-binding domain (NOD)-like receptor protein 3 (NLRP3) inflammasome pathways are thought to be crucial players in this link. Activation of these pathways ends by releasing of different inflammatory mediators involved in CVD and depression pathophysiology...
February 13, 2023: Journal of Neuroimmune Pharmacology: the Official Journal of the Society on NeuroImmune Pharmacology
https://read.qxmd.com/read/36730700/unhealthy-lifestyle-impacts-on-biological-systems-involved-in-stress-response-hypothalamic-pituitary-adrenal-axis-inflammation-and-autonomous-nervous-system
#45
JOURNAL ARTICLE
Laura Mandelli, Yuri Milaneschi, Sarah Hiles, Alessandro Serretti, Brenda W Penninx
An unhealthy lifestyle has a critical role in the pathogenesis and course of several chronic disorders. It has been hypothesized that lifestyle may also impact biological systems involved in stress response. A global index of unhealthy lifestyle was calculated based on the cumulative presence of five self-reported lifestyle habits (smoking, excessive alcohol use, drug use, low physical activity and short sleep) in 2783 participants (18-65 years) from the Netherlands Study of Depression and Anxiety. The functioning of biological stress systems was based on multiple physiological measures of cortisol, inflammatory cytokines and autonomic cardiac activity...
November 11, 2022: International Clinical Psychopharmacology
https://read.qxmd.com/read/36672598/prophylactic-effect-of-bovine-colostrum-on-intestinal-microbiota-and-behavior-in-wild-type-and-zonulin-transgenic-mice
#46
JOURNAL ARTICLE
Birna Asbjornsdottir, Alba Miranda-Ribera, Maria Fiorentino, Takumi Konno, Murat Cetinbas, Jinggang Lan, Ruslan I Sadreyev, Larus S Gudmundsson, Magnus Gottfredsson, Bertrand Lauth, Bryndis Eva Birgisdottir, Alessio Fasano
The microbiota-gut-brain axis (MGBA) involves bidirectional communication between intestinal microbiota and the gastrointestinal (GI) tract, central nervous system (CNS), neuroendocrine/neuroimmune systems, hypothalamic-pituitary-adrenal (HPA) axis, and enteric nervous system (ENS). The intestinal microbiota can influence host physiology and pathology. Dysbiosis involves the loss of beneficial microbial input or signal, diversity, and expansion of pathobionts, which can lead to loss of barrier function and increased intestinal permeability (IP)...
December 29, 2022: Biomedicines
https://read.qxmd.com/read/36592971/the-heart-is-at-risk-understanding-stroke-heart-brain-interactions-with-focus-on-neurogenic-stress-cardiomyopathy-a-review
#47
REVIEW
Mairi Ziaka, Aristomenis Exadaktylos
In recent years, it has been convincingly demonstrated that acute brain injury may cause severe cardiac complications-such as neurogenic stress cardiomyopathy (NSC), a specific form of takotsubo cardiomyopathy. The pathophysiology of these brain-heart interactions is complex and involves sympathetic hyperactivity, activation of the hypothalamic-pituitary-adrenal axis, as well as immune and inflammatory pathways. There have been great strides in our understanding of the axis from the brain to the heart in patients with isolated acute brain injury and more specifically in patients with stroke...
January 2023: Journal of Stroke
https://read.qxmd.com/read/36566434/the-pituitary-adenylate-cyclase-activating-polypeptide-pacap-system-of-the-central-amygdala-mediates-the-detrimental-effects-of-chronic-social-defeat-stress-in-rats
#48
JOURNAL ARTICLE
Mariel P Seiglie, Lauren Lepeak, Clara Velázquez-Sanchez, Antonio Ferragud, Teresa Le, Pietro Cottone, Valentina Sabino
Many psychiatric diseases stem from an inability to cope with stressful events, as chronic stressors can precipitate or exacerbate psychopathologies. The neurobiological mechanisms underlying the response to chronic stress and the resulting anxiety states remain poorly understood. Stress neuropeptides in the extended amygdala circuitry mediate the behavioral response to stress, and hyperactivity of these systems has been hypothesized to be responsible for the emergence of persistent negative outcomes and for the pathogenesis of anxiety-related and trauma-related disorders...
2022: ENeuro
https://read.qxmd.com/read/36565761/a-human-relevant-mixture-of-endocrine-disrupting-chemicals-induces-changes-in-hippocampal-dna-methylation-correlating-with-hyperactive-behavior-in-male-mice
#49
JOURNAL ARTICLE
Michela Di Criscio, Jennifer Ekholm Lodahl, Antonios Stamatakis, Efthymia Kitraki, Ioannis Bakoyiannis, Anastasia Repouskou, Carl-Gustaf Bornehag, Chris Gennings, Diana Lupu, Joëlle Rüegg
Humans are ubiquitously exposed to endocrine disrupting chemicals (EDCs), substances that interfere with endogenous hormonal signaling. Exposure during early development is of particular concern due to the programming role of hormones during this period. A previous epidemiological study has shown association between prenatal co-exposure to 8 EDCs (Mixture N1) and language delay in children, suggesting an effect of this mixture on neurodevelopment. Furthermore, in utero exposure to Mixture N1 altered gene expression and behavior in adult mice...
December 21, 2022: Chemosphere
https://read.qxmd.com/read/36536630/the-gut-microbiota-hpa-axis-and-brain-in-adolescent-onset-depression-probiotics-as-a-novel-treatment
#50
JOURNAL ARTICLE
Daniel Freimer, Tony T Yang, Tiffany C Ho, Olga Tymofiyeva, Cherry Leung
Stress-associated disruptions in the development of frontolimbic regions may play a critical role in the emergence of adolescent-onset depression. These regions are particularly sensitive to Hypothalamic-Pituitary-Adrenal (HPA) axis signaling. The HPA axis is hyperactive in adolescent depression, and interventions that attenuate such hyperactivity hold promise as potential treatments. The Microbiome-Gut-Brain (MGB) axis is an important pathway through which stress dysregulates HPA-axis activity and thus exerts deleterious effects on the adolescent brain...
December 2022: Brain, behavior, & immunity health
https://read.qxmd.com/read/36481932/prenatal-stress-modulates-hpa-axis-homeostasis-of-offspring-through-dentate-tert-independently-of-glucocorticoids-receptor
#51
JOURNAL ARTICLE
Meng-Ying Liu, Lu-Lu Wei, Xian-Hui Zhu, Hua-Chen Ding, Xiang-Hu Liu, Huan Li, Yuan-Yuan Li, Zhou Han, Lian-Di Li, Zi-Wei Du, Ya-Ping Zhou, Jing Zhang, Fan Meng, Yu-Lin Tang, Xiao Liu, Chun Wang, Qi-Gang Zhou
In response to stressful events, the hypothalamic-pituitary-adrenal (HPA) axis is activated, and consequently glucocorticoids are released by the adrenal gland into the blood circulation. A large body of research has illustrated that excessive glucocorticoids in the hippocampus exerts negative feedback regulation of the HPA axis through glucocorticoid receptor (GR), which is critical for the homeostasis of the HPA axis. Maternal prenatal stress causes dysfunction of the HPA axis feedback mechanism in their offspring in adulthood...
December 8, 2022: Molecular Psychiatry
https://read.qxmd.com/read/36458076/a-systematic-review-and-meta-analysis-of-serum-and-plasma-cortisol-levels-in-depressed-patients-versus-control
#52
REVIEW
Manoj K Sahu, Rajesh K Dubey, Alka Chandrakar, Mahesh Kumar, Mahendra Kumar
Depression is associated with hyperactivity of the hypothalamo pituitary adrenal axis. Cortisol is a steroid hormone, released from the adrenal gland and is considered to be a biological marker of stress and anxiety. Serum or plasma cortisol levels have been previously studied in depressive patients but reported contradictory results. The present meta analysis aims to assess the serum or plasma concentration of cortisol in depressive patients compared with controls. We have conducted a systematic review with sequential meta analysis according to the Preferred Reporting Items for Systematic Reviews and Meta Analyses (PRISMA) guidelines...
2022: Indian Journal of Psychiatry
https://read.qxmd.com/read/36434056/salt-inducible-kinase-1-creb-regulated-transcription-coactivator-1-signalling-in-the-paraventricular-nucleus-of-the-hypothalamus-plays-a-role-in-depression-by-regulating-the-hypothalamic-pituitary-adrenal-axis
#53
JOURNAL ARTICLE
Yuan Wang, Ling Liu, Jiang-Hong Gu, Cheng-Niu Wang, Wei Guan, Yue Liu, Wen-Qian Tang, Chun-Hui Ji, Yan-Mei Chen, Jie Huang, Wei-Yu Li, Tian-Shun Shi, Wei-Jia Chen, Bao-Lun Zhu, Bo Jiang
Elucidating the molecular mechanism underlying the hyperactivity of the hypothalamic-pituitary-adrenal axis during chronic stress is critical for understanding depression and treating depression. The secretion of corticotropin-releasing hormone (CRH) from neurons in the paraventricular nucleus (PVN) of the hypothalamus is controlled by salt-inducible kinases (SIKs) and CREB-regulated transcription co-activators (CRTCs). We hypothesised that the SIK-CRTC system in the PVN might contribute to the pathogenesis of depression...
November 25, 2022: Molecular Psychiatry
https://read.qxmd.com/read/36410589/depression-and-cardiovascular-diseases
#54
REVIEW
Tsuyoshi Shiga
Depression is a well-known risk factor for adverse cardiovascular outcomes in patients with cardiovascular diseases. The prevalence of depression in patients with cardiovascular diseases has been reported to be approximately 20 %. A two-step depression screening protocol using the 2-item Patient Health Questionnaire (PHQ-2) and the 9-item Patient Health Questionnaire (PHQ-9) is recommended for patients with cardiovascular diseases. Cardiovascular diseases and depression share a common pathology, including increased activity of the sympathetic nervous system, hyperactivity of hypothalamic-pituitary-adrenal axis, and inflammation...
November 18, 2022: Journal of Cardiology
https://read.qxmd.com/read/36358502/possible-effects-and-mechanisms-of-dietary-natural-products-and-nutrients-on-depression-and-anxiety-a-narrative-review
#55
REVIEW
Si-Xia Wu, Jiahui Li, Dan-Dan Zhou, Ruo-Gu Xiong, Si-Yu Huang, Adila Saimaiti, Ao Shang, Hua-Bin Li
Depression and anxiety are severe public health problems and have attracted more and more attention from researchers of food science and nutrition. Dietary natural products and nutrients, such as fish, coffee, tea, n-3 PUFA, lycopene, and dietary fiber, could play a vital role in the prevention and management of these diseases. The potential mechanisms of action mainly include inhibiting inflammation, ameliorating oxidative stress, modulating the microbiota-gut-brain axis, suppressing hypothalamic-pituitary-adrenal axis hyperactivity, and regulating the levels of monoamine neurotransmitters...
October 28, 2022: Antioxidants (Basel, Switzerland)
https://read.qxmd.com/read/36340278/are-nocebo-effects-in-adulthood-linked-to-prenatal-maternal-cortisol-levels
#56
JOURNAL ARTICLE
Fabrizio Benedetti, Martina Amanzio, Fabio Giovannelli, Karen Craigs-Brackhahn, Claudia Arduino, Aziz Shaibani
Objective: Placebo-induced adverse events, or nocebo effects, occur when doctor-patient communication anticipates the onset of negative symptoms. They have been found to correlate with the anxiety-related activity of the hypothalamic-pituitary-adrenal system. Here we try to determine if prenatal hyperactivity of this system, as assessed through plasma cortisol, may influence nocebo effects in adulthood. Method: We investigated the rate and magnitude of nocebo effects in 378 adults whose prenatal maternal plasma cortisol was measured during the first, second and third trimester of pregnancy...
October 2022: Clinical Neuropsychiatry
https://read.qxmd.com/read/36300881/therapeutic-potential-of-plant-iridoids-in-depression-a-review
#57
REVIEW
Yaoyao Kou, Zhihao Li, Tong Yang, Xue Shen, Xin Wang, Haopeng Li, Kun Zhou, Luyao Li, Zhaodi Xia, Xiaohui Zheng, Ye Zhao
CONTEXT: Depression is a mental disorder characterized by low mood, reduced interest, impaired cognitive function, and vegetative symptoms such as sleep disturbances or poor appetite. Iridoids are the active constituents in several Chinese classical antidepressant formulae such as Yueju Pill, Zhi-Zi-Hou-Po Decoction, Zhi-Zi-Chi Decoction, and Baihe Dihuang Decoction. Parallel to their wide usages, iridoids are considered potential lead compounds for the treatment of neurological diseases...
December 2022: Pharmaceutical Biology
https://read.qxmd.com/read/36291310/suppressive-effects-of-isofraxidin-on-depressive-like-behaviors-induced-by-chronic-unpredictable-mild-stress-in-mice
#58
JOURNAL ARTICLE
Xiaoli Wu, Jingwen Gu, Zhicong Zou, Meng Yu, Chen Zhang, Qinghui Xiao, Xin Chen, Chuwen Li
Isofraxidin is an active component of several traditional and functional plants that have beneficial properties for neurodegenerative diseases. In this study, we examined whether isofraxidin exhibited antidepressant-like effects in chronic unpredictable mild stress (CUMS)-induced mice. Firstly, isofraxidin could reverse CUMS-induced decrease in body weight gain in mice. Additionally, in the sucrose preference test (SPT), isofraxidin reversed the decrease in sucrose consumption due to CUMS-induced depressive-like behavior...
October 11, 2022: Brain Sciences
https://read.qxmd.com/read/36185472/crosstalk-of-alzheimer-s-disease-phenotype-hpa-axis-splenic-oxidative-stress-and-frailty-in-late-stages-of-dementia-with-special-concerns-on-the-effects-of-social-isolation-a-translational-neuroscience-approach
#59
JOURNAL ARTICLE
Aida Muntsant, Lydia Giménez-Llort
Coping with emotional stressors strongly impacts older people due to their age-related impaired neuroendocrine and immune systems. Elevated cortisol levels seem to be associated with an increased risk of cognitive decline and dementia. In Alzheimer's disease (AD), alterations in the innate immune system result in crosstalk between immune mediators and neuronal and endocrine functions. Besides, neuropsychiatric symptoms such as depression, anxiety, or agitation are observed in most patients. Here, we studied the psychophysiological response to intrinsic (AD-phenotype) and extrinsic (anxiogenic tests) stress factors and their relation to liver, kidneys, heart, and spleen oxidative status in 18-months-old female gold-standard C57BL/6 mice and 3xTg-AD mice model for AD...
2022: Frontiers in Aging Neuroscience
https://read.qxmd.com/read/36181653/antidepressant-effects-of-cherry-leaf-decoction-on-a-chronic-unpredictable-mild-stress-rat-model-based-on-the-glu-gaba-gln-metabolic-loop
#60
JOURNAL ARTICLE
Chuan Jiang, Hua Wang, Jiaying Qi, Jinghan Li, Qianqian He, Chaonan Wang, Yonggang Gao
Cherry leaves (Prunus pseudocerasus Lindl. [Rosaceae]), a traditional Chinese herbal medicine, can regulate the factors closely related to depression including inflammatory cytokines, oxidative stress and blood glucose level. However, the antidepressant effects of cherry leaves and underlying neuromodulatory mechanisms remain relatively have not been elucidated explicitly. The present study investigated the antidepressant effects of cherry leaf decoction (CLD). The underlying neuromodulatory mechanism was explored by examining the glutamate (Glu)/γ-aminobutyric acid (GABA)-glutamine (Gln) metabolic loop...
October 1, 2022: Metabolic Brain Disease
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