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JOURNAL ARTICLE
Sanjay Basu, John S Yudkin, Mohammed Jawad, Hala Ghattas, Bassam Abu Hamad, Zeina Jamaluddine, Gloria Safadi, Marie-Elizabeth Ragi, Raeda El Sayed Ahmad, Eszter P Vamos, Christopher Millett
We sought to assess the effectiveness and cost-effectiveness of potential new public health and healthcare NCD risk reduction efforts among Palestinians in Gaza. We created a microsimulation model using: (i) a cross-sectional household survey of NCD risk factors among 4,576 Palestinian adults aged ≥40 years old in Gaza; (ii) a modified Delphi process among local public health experts to identify potentially feasible new interventions; and (iii) reviews of intervention cost and effectiveness, modified to the Gazan and refugee contexts...
2024: PLOS Glob Public Health
#2
COMPARATIVE STUDY
Gerson Gatass Orro de Campos, Leandro Steinhorst Goelzer, Tiago Rodrigues de Lemos Augusto, Gisele Walter Barbosa, Gaspar R Chiappa, Erik H van Iterson, Paulo T Muller
BACKGROUND: Currently, excess ventilation has been grounded under the relationship between minute-ventilation/carbon dioxide output ( V ˙ E - V ˙ CO 2 ). Alternatively, a new approach for ventilatory efficiency ( η E V ˙ ) has been published. OBJECTIVE: Our main hypothesis is that comparatively low levels of η E V ˙ between chronic heart failure (CHF) and chronic obstructive pulmonary disease (COPD) are attainable for a similar level of maximum and submaximal aerobic performance, conversely to long-established methods ( V ˙ E - V ˙ CO 2 slope and intercept)...
2024: Arquivos Brasileiros de Cardiologia
#3
JOURNAL ARTICLE
Byron Jones, Mandy Ryan, Nigel S Cook, Florian S Gutzwiller
No abstract text is available yet for this article.
May 2, 2024: International Journal of Technology Assessment in Health Care
#4
JOURNAL ARTICLE
Siddharth A, Raymond Haward, Ananya Chakraborty
Objective The objective of this study was to evaluate errors in the use of metered-dose inhalers (MDIs) among patients diagnosed with asthma or chronic obstructive pulmonary disease (COPD). Additionally, we aimed to assess improvements following corrective interventions. Settings and design This cross-sectional study was done by simple random sampling. Methods and materials This study was done at a tertiary care center in South India in an outpatient department and ward for tuberculosis and chest disease to find out the right way to use an MDI and investigate the reasons why people with asthma and COPD don't use it correctly...
April 2024: Curēus
#5
REVIEW
Aman Goyal, Fatima Ali Raza, Samia Aziz Sulaiman, Abeer Shahzad, Syeda Ilsa Aaqil, Mahrukh Iqbal, Binish Javed, Prakriti Pokhrel
Saffron, derived from Crocus sativus, is gaining research attention for potential therapeutic applications. Its diverse clinical applications extend to cardiovascular health, diabetes management, sleep quality, psychiatric illnesses, and rheumatoid arthritis. Saffron's positive effects on blood pressure, glucose levels, cognitive function, and inflammatory markers contribute to its versatility. Additionally, carotenoids like crocin and crocetin suggest anti-cancer potential. In terms of reproductive health, saffron's impact on male reproductive health shows conflicting findings on semen parameters...
May 2024: Annals of Medicine and Surgery
#6
Shihong Qin, Huifang Teng, Aiping Li, Lile Wang, Ruicheng Hu, Daiyan Fu
BACKGROUND: Takotsubo syndrome, which is often induced by physical or psychological stress, is typically a cardiac syndrome with transient left ventricular dysfunction in the absence of obstructive coronary artery disease. Subarachnoid hemorrhage with typical symptoms and signs is frequently reported, whereas the incidence of subarachnoid hemorrhage with Takotsubo syndrome as the prominent manifestation without a typical headache is rarely reported. CASE DESCRIPTION: We present a rare case of a 63-year-old male patient with cough and fever as the first manifestations, accompanied by mild dizziness, headache, and mental discomfort; however, the patient was eventually diagnosed with atypical subarachnoid hemorrhage with Takotsubo syndrome...
May 15, 2024: Heliyon
#7
JOURNAL ARTICLE
Redaktion Facharztmagazine
No abstract text is available yet for this article.
May 2024: MMW Fortschritte der Medizin
#8
REVIEW
Adrian Gillissen
No abstract text is available yet for this article.
May 2024: MMW Fortschritte der Medizin
#9
JOURNAL ARTICLE
Mao-Sheng Hwang, Ching-Chia Kuo, Chao-Jan Wang, Wen-Jen Su, Jaw-Ji Chu, Hung-Tao Chung, Hsiang-Ju Hsiao, Yi-Jung Chang
BACKGROUND: Previous studies on congenital heart diseases (CHD) associated with dextrocardia were based on selective patient databases and did not reflect the full spectrum of dextrocardia in the general population. Additionally, these studies had complex classification and presentation. Nor did these studies elaborate on the distribution of the associated CHD's complexity, the various segmental connections, and associated CHD among the four visceroatrial situs. METHODS: We retrospectively reviewed the medical records of 211 children with primary dextrocardia...
April 23, 2024: Pediatrics and Neonatology
#10
REVIEW
Kori Ascher, Shirin Shafazand
Obstructive sleep apnea (OSA) has emerged as a significant and prevalent comorbidity associated with chronic lung diseases, including chronic obstructive pulmonary disease, asthma, and interstitial lung diseases. These overlap syndromes are associated with worse patient-reported outcomes (sleep quality, quality of life measures, mental health) than each condition independently. Observational studies suggest that patients with overlap syndrome who are adherent to positive airway pressure therapy report improved quality of life, sleep quality, depression, and daytime symptoms...
June 2024: Sleep Medicine Clinics
#11
REVIEW
Lee K Brown
Hypoventilation is a complication that is not uncommon in chronic obstructive pulmonary disease and calls for both medical treatment of the underlying disease and, frequently, noninvasive ventilation either during exacerbations requiring hospitalization or in a chronic state in the patient at home. Obesity hypoventilation syndrome by definition is associated with ventilatory failure and hypercapnia. It may or may not be accompanied by obstructive sleep apnea, which when detected becomes an additional target for positive airway pressure treatment...
June 2024: Sleep Medicine Clinics
#12
REVIEW
Chitra Lal
Obstructive sleep apnea (OSA) is very prevalent in sarcoidosis patients. Sarcoidosis of the upper respiratory tract may affect upper airway patency and increase the risk of OSA. Weight gain due to steroid use, upper airway myopathy due to steroids and sarcoidosis itself, and interstitial lung disease with decreased upper airway patency are other reasons for the higher OSA prevalence seen in sarcoidosis. Several clinical manifestations such as fatigue, hypersomnolence, cognitive deficits, and pulmonary hypertension are common to both OSA and sarcoidosis...
June 2024: Sleep Medicine Clinics
#13
REVIEW
Marta Marin-Oto, Jose M Marin
In patients with chronic obstructive pulmonary disease (COPD) and asthma, exacerbations determine the natural history of both diseases. Patients with both respiratory diseases who suffer from obstructive sleep apnea (OSA) as a comorbidity (overlap syndromes) have a higher risk of exacerbations and hospitalization. In cases of OSA/COPD and OSA/asthma, continuous positive airway pressure treatment is indicated. Adequate adherence to therapy appears to reduce exacerbations and their severity, especially in OSA/COPD overlap...
June 2024: Sleep Medicine Clinics
#14
REVIEW
Walter T McNicholas
Chronic obstructive pulmonary disease (COPD) and obstructive sleep apnea (OSA) have important bidirectional relationships that influence the pathophysiology of each disorder. The slim hyperinflated "pink puffer" phenotype of COPD protects against OSA, whereas the heavier "blue bloater" phenotype predisposes to OSA by fluid retention. OSA may aggravate COPD by promoting airway inflammation. COPD-OSA overlap patients have lower quality of life and are at higher risk of cardiovascular comorbidity than either disorder alone due to greater nocturnal oxygen desaturation and sympathetic activation...
June 2024: Sleep Medicine Clinics
#15
REVIEW
Avantika Nathani, Amy Attaway, Reena Mehra
Obstructive sleep apnea (OSA) is a common sleep-related breathing disorder. Its prevalence has increased due to increasing obesity and improved screening and diagnostic strategies. OSA overlaps with cardiopulmonary diseases to promote intermittent hypoxia and autonomic dysfunction. Intermittent hypoxia increases the risk for oxidative stress and inflammation, which promotes endothelial dysfunction and predisposes to atherosclerosis and other cardiovascular complications. OSA is associated with an increased sympathetic nervous system drive resulting in autonomic dysfunction leading to worsening of cardiopulmonary diseases...
June 2024: Sleep Medicine Clinics
#16
JOURNAL ARTICLE
Ashleigh Howes, Clare Rogerson, Nikolai Belyaev, Tina Karagyozova, Radu Rapiteanu, Ricardo Fradique, Nicola Pellicciotta, David Mayhew, Catherine Hurd, Stefania Crotta, Tanya Singh, Kevin Dingwell, Anniek Myatt, Navot Arad, Hikmatyar Hasan, Hielke Bijlsma, Aliza Panjwani, Vinaya Vijayan, George Young, Angela Bridges, Sebastien Petit-Frere, Joanna Betts, Chris Larminie, James C Smith, Edith M Hessel, David Michalovich, Louise Walport, Pietro Cicuta, Andrew J Powell, Soren Beinke, Andreas Wack
SNPs in the FAM13A locus are amongst the most commonly reported risk alleles associated with chronic obstructive pulmonary disease (COPD) and other respiratory diseases, however the physiological role of FAM13A is unclear. In humans, two major protein isoforms are expressed at the FAM13A locus: 'long' and 'short', but their functions remain unknown, partly due to a lack of isoform conservation in mice. We performed in-depth characterisation of organotypic primary human airway epithelial cell subsets and show that multiciliated cells predominantly express the FAM13A long isoform containing a putative N-terminal Rho GTPase activating protein (RhoGAP) domain...
May 1, 2024: American Journal of Respiratory Cell and Molecular Biology
#17
JOURNAL ARTICLE
Felix Kluge, Yonatan E Brand, M Encarna Micó-Amigo, Stefano Bertuletti, Ilaria D'Ascanio, Eran Gazit, Tecla Bonci, Cameron Kirk, Arne Küderle, Luca Palmerini, Anisoara Paraschiv-Ionescu, Francesca Salis, Abolfazl Soltani, Martin Ullrich, Lisa Alcock, Kamiar Aminian, Clemens Becker, Philip Brown, Joren Buekers, Anne-Elie Carsin, Marco Caruso, Brian Caulfield, Andrea Cereatti, Lorenzo Chiari, Carlos Echevarria, Bjoern Eskofier, Jordi Evers, Judith Garcia-Aymerich, Tilo Hache, Clint Hansen, Jeffrey M Hausdorff, Hugo Hiden, Emily Hume, Alison Keogh, Sarah Koch, Walter Maetzler, Dimitrios Megaritis, Martijn Niessen, Or Perlman, Lars Schwickert, Kirsty Scott, Basil Sharrack, David Singleton, Beatrix Vereijken, Ioannis Vogiatzis, Alison Yarnall, Lynn Rochester, Claudia Mazzà, Silvia Del Din, Arne Mueller
BACKGROUND: Wrist-worn inertial sensors are used in digital health for evaluating mobility in real-world environments. Preceding the estimation of spatiotemporal gait parameters within long-term recordings, gait detection is an important step to identify regions of interest where gait occurs, which requires robust algorithms due to the complexity of arm movements. While algorithms exist for other sensor positions, a comparative validation of algorithms applied to the wrist position on real-world data sets across different disease populations is missing...
May 1, 2024: JMIR Formative Research
#18
EDITORIAL
Molly M Baldwin, Sally J Singh
No abstract text is available yet for this article.
May 2024: Annals of the American Thoracic Society
#19
Radha Nangliya, Vaishnavi Yadav, Sojwal P Nandanwar
Chronic obstructive pulmonary disease (COPD) often coexists with hypertension and hypothyroidism, posing challenges in management. Physiotherapy is crucial for improving respiratory function and quality of life in COPD patients. This case report details the physiotherapy management of an 84-year-old male with COPD, hypertension, and well-controlled hypothyroidism. The patient presented with worsening cough, breathlessness, and barrel chest. Diagnostic investigations confirmed COPD with respiratory alkalosis, hypoxemia, and well-controlled hypothyroidism...
March 2024: Curēus
#20
JOURNAL ARTICLE
Chelsea S Harris, Hui-Jie Lee, Isaac S Alderete, Samantha E Halpern, Alexander Gordee, Ian Jamieson, Charles Scales, Matthew G Hartwig
OBJECTIVES: To identify patient and process factors that contribute to the high cost of lung transplantation (LTx) in the perioperative period, which may allow transplant centers to evaluate situations in which transplantation is most cost-effective to inform judicious resource allocation, avoid futile care, and reduce costs. METHODS: The MarketScan Research databases were used to identify 582 privately insured patients undergoing single or bilateral LTx between 2013 and 2019...
April 2024: JTCVS open
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