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JOURNAL ARTICLE
Andrew Joseph Carter, Jad Raffoul, Linden Lane, Leah LeSage, Shelley Langenhorst, Matthew Smolin, Michael Dempsey, David Hughes, Michael Gleason, Steven Weiss, William D Anderson
INTRODUCTION: Cardiogenic shock (CS) complicates 5%-15% of cases of acute myocardial infarction (AMI) with inpatient mortality greater than 40%. The implementation of standardised protocols may improve clinical outcomes in patients with AMI-CS. METHODS AND ANALYSIS: The Durango model is a prospective single-centre registry designed to enable early identification of patients with STEMI-CS to facilitate primary reperfusion therapy with a shock team management algorithm in a rural level II heart attack centre...
December 7, 2023: Open Heart
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JOURNAL ARTICLE
Jing Chen, Joseph R Lane, Kelvin H Bates, Henrik G Kjaergaard
Despite its impact on the climate, the mechanism of methanesulfonic acid (MSA) formation in the oxidation of dimethyl sulfide (DMS) remains unclear. The DMS + OH reaction is known to form methanesulfinic acid (MSIA), methane sulfenic acid (MSEA), the methylthio radical (CH3 S), and hydroperoxymethyl thioformate (HPMTF). Among them, HPMTF reacts further to form SO2 and OCS, while the other three form the CH3 SO2 radical. Based on theoretical calculations, we find that the CH3 SO2 radical can add O2 to form CH3 S(O)2 OO, which can react further to form MSA...
December 5, 2023: Environmental Science & Technology
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JOURNAL ARTICLE
David M Desmet, Meghan E Kazanski, Joseph P Cusumano, Jonathan B Dingwell
BACKGROUND: Walking requires frequent maneuvers to navigate changing environments with shifting goals. Humans accomplish maneuvers and simultaneously maintain balance primarily by modulating their foot placement, but a direct trade-off between these two objectives has been proposed. As older adults may rely more on foot placement to maintain lateral balance, they may be less able to adequately adapt stepping to perform lateral maneuvers. RESEARCH QUESTION: How do older adults adapt stepping to enact lateral lane-change maneuvers, and how do physical and perceived ability influence their task performance? METHODS: Twenty young (21...
November 24, 2023: Gait & Posture
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JOURNAL ARTICLE
Sarah J Shareef, Shanelle Jackson, Brittany N Lane, Ellanya Kallabat, Deepika Boopathy, Joseph W Fakhoury, Henry W Lim
BACKGROUND/PURPOSE: Exposure to sunlight has been shown to cause pigmentary alterations, photoaging and photocarcinogenesis. Understanding photoprotective patterns in adolescent populations is beneficial to public health initiatives. We utilized data provided by the American College Health Association's National College Health Assessment to evaluate photoprotective behaviors among adolescent populations. METHODS: Behavioral questions related to photoprotection were analyzed from the American College Health Association (ACHA) National College Health Assessment (NCHA) (Version III)...
November 28, 2023: Photodermatology, Photoimmunology & Photomedicine
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JOURNAL ARTICLE
Haana McMurray, Jason R Lewis, Wesley L Brundridge, Theepica Jeyarajah, Sorana Raiciulescu, Joseph Lopreiato, Eva Chou
PURPOSE: Orbital compartment syndrome (OCS) is an ocular emergency requiring prompt decompression with a lateral canthotomy and cantholysis (LCC) within 2 hours. This study evaluates the feasibility and effectiveness of a standardized LCC curriculum to train medical students to identify and treat OCS. METHODS: This was a prospective, non-randomized, non-comparative cohort study of 39 novice first-year medical students with no prior LCC training who underwent a standardized LCC curriculum incorporating both didactic and hands-on procedural training...
November 8, 2023: Military Medicine
#26
JOURNAL ARTICLE
Jonathan E Ron, Joseph d'Alesandro, Victor Cellerin, Raphael Voituriéz, Benoit Ladoux, Nir S Gov
Collective cell migration, whereby cells adhere to form multi-cellular clusters that move as a single entity, play an important role in numerous biological processes, such as during development and cancer progression. Recent experimental work focused on migration of one-dimensional cellular clusters, confined to move along adhesive lanes, as a simple geometry in which to systematically study this complex system. One-dimensional migration also arises in the body when cells migrate along blood vessels, axonal projections and narrow cavities between tissues...
November 6, 2023: Biophysical Journal
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JOURNAL ARTICLE
Nitish Sood, Anish Sangari, Arnav Goyal, Christina Sun, Madison Horinek, Joseph Andy Hauger, Lane Perry
BACKGROUND: Cardiac arrest is a leading cause of mortality in America and has increased in the incidence of cases over the last several years. Cardiopulmonary resuscitation (CPR) increases survival outcomes in cases of cardiac arrest; however, healthcare workers often do not perform CPR within recommended guidelines. Real-time audiovisual feedback (RTAVF) devices improve the quality of CPR performed. This systematic review and meta-analysis aims to compare the effect of RTAVF-assisted CPR with conventional CPR and to evaluate whether the use of these devices improved outcomes in both in-hospital cardiac arrest (IHCA) and out-of-hospital cardiac arrest (OHCA) patients...
October 26, 2023: World Journal of Cardiology
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JOURNAL ARTICLE
Jonathan B Dingwell, Anna C Render, David M Desmet, Joseph P Cusumano
People rarely walk in straight lines. Instead, we make frequent turns or other maneuvers. Spatiotemporal parameters fundamentally characterize gait. For straight walking, these parameters are well-defined for the task of walking on a straight path. Generalizing these concepts to non-straight walking, however, is not straightforward. People follow non-straight paths imposed by their environment (sidewalk, windy hiking trail, etc.) or choose readily-predictable, stereotypical paths of their own. People actively maintain lateral position to stay on their path and readily adapt their stepping when their path changes...
October 19, 2023: Journal of Biomechanics
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JOURNAL ARTICLE
Kinya Seo, Yuta Yamamoto, Anna Kirillova, Masataka Kawana, Sunil Yadav, Yong Huang, Qianru Wang, Kerry V Lane, Beth L Pruitt, Marco V Perez, Daniel Bernstein, Joseph C Wu, Matthew T Wheeler, Victoria N Parikh, Euan A Ashley
BACKGROUND: Hypercontractility and arrhythmia are key pathophysiologic features of hypertrophic cardiomyopathy (HCM), the most common inherited heart disease. β-Adrenergic receptor antagonists (β-blockers) are the first-line therapy for HCM. However, β-blockers commonly selected for this disease are often poorly tolerated in patients, where heart-rate reduction and noncardiac effects can lead to reduced cardiac output and fatigue. Mavacamten, myosin ATPase inhibitor recently approved by the US Food and Drug Administration, has demonstrated the ability to ameliorate hypercontractility without lowering heart rate, but its benefits are so far limited to patients with left ventricular (LV) outflow tract obstruction, and its effect on arrhythmia is unknown...
October 18, 2023: Circulation
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JOURNAL ARTICLE
Andrea Lane Eastman, Mayra K Cazares-Minero, Lindsey Palmer, Wendy Wiegmann, John J Prindle, Joseph Magruder
BACKGROUND: Young people in foster care frequently experience early parenting, and U.S. law requires the documentation of parents in care. The extent to which the child protection system (CPS) has accurately collected information on parents in care remains largely unknown and has ramifications for the planning and delivery of services. OBJECTIVE: Using California as a case study, this study documented young mothers in care using birth records, determined the proportion of mothers correctly identified in CPS records, and compared characteristics and placements of mothers who were or were not identified...
September 20, 2023: Child Abuse & Neglect
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JOURNAL ARTICLE
Javier Sanchez, Christopher Woods, Jason Zagrodzky, Jose Nazari, Matthew J Singleton, Amir Schricker, Annie Ruppert, Babette Brumback, Benjamin Jenny, Charles Athill, Christopher Joseph, Dipak Shah, Gaurav Upadhyay, Erik Kulstad, John Cogan, Jordan Leyton-Mange, Julie Cooper, Kamala Tamirisa, Samuel Omotoye, Saroj Timilsina, Alejandro Perez-Verdia, Andrew Kaplan, Apoor Patel, Alex Ro, Andrew Corsello, Arun Kolli, Brian Greet, Danya Willms, David Burkland, Demetrio Castillo, Firas Zahwe, Hemal Nayak, James Daniels, John MacGregor, Matthew Sackett, W Michael Kutayli, Michel Barakat, Robert Percell, Spyridon Akrivakis, Steven C Hao, Taylor Liu, Ambrose Panico, Archana Ramireddy, Thomas Dewland, Edward P Gerstenfeld, Daniel Benhayon Lanes, Edward Sze, Gregory Francisco, Jose Silva, Julia McHugh, Kai Sung, Leon Feldman, Nicholas Serafini, Raymond Kawasaki, Richard Hongo, Richard Kuk, Robert Hayward, Shirley Park, Andrew Vu, Christopher Henry, Shane Bailey, Steven Mickelsen, Taresh Taneja, Westby Fisher, Mark Metzl
BACKGROUND: Active esophageal cooling reduces the incidence of endoscopically identified severe esophageal lesions during radiofrequency (RF) catheter ablation of the left atrium for the treatment of atrial fibrillation. A formal analysis of the atrioesophageal fistula (AEF) rate with active esophageal cooling has not previously been performed. OBJECTIVES: The authors aimed to compare AEF rates before and after the adoption of active esophageal cooling. METHODS: This institutional review board (IRB)-approved study was a prospective analysis of retrospective data, designed before collecting and analyzing the real-world data...
September 12, 2023: JACC. Clinical Electrophysiology
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JOURNAL ARTICLE
Anu Rebbapragada, Lane Cariazo, David Elchuk, Hossam Abdelrahman, Dang Pham, Jerusha Raveendraraj, Killol Chokshi, Nirochile Joseph, Elena Gouzenkova, Harpreet Gill, Peter Blecher
The COVID-19 pandemic highlighted the critical need for rapid and accurate molecular diagnostic testing. The Cue COVID-19 Point-of-Care Test (Cue POCT) is a nucleic acid amplification test (NAAT), authorized by Health Canada and FDA as a POCT for SARS-CoV-2 detection. Cue POCT was deployed at a network of clinics in Ontario, Canada with n = 13,848 patrons tested between 17 July 2021 and 31 January 2022. The clinical performance and operational experience with Cue POCT were examined for this testing population composed mostly of asymptomatic individuals (93...
September 20, 2023: Microbiology Spectrum
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Cleopa Omondi, Austin Chou, Kenneth A Fond, Kazuhito Morioka, Nadine R Joseph, Jeffrey A Sacramento, Emma Iorio, Abel Torres-Espin, Hannah L Radabaugh, Jacob A Davis, Jason H Gumbel, J Russell Huie, Adam R Ferguson
Western blot is a popular biomolecular analysis method for measuring the relative quantities of independent proteins in complex biological samples. However, variability in quantitative western blot data analysis poses a challenge in designing reproducible experiments. The lack of rigorous quantitative approaches in current western blot statistical methodology may result in irreproducible inferences. Here we describe best practices for the design and analysis of western blot experiments, with examples and demonstrations of how different analytical approaches can lead to widely varying outcomes...
August 5, 2023: bioRxiv
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JOURNAL ARTICLE
Gabby B Joseph, Melia Takakusagi, Gino Arcilla, John A Lynch, Valentina Pedoia, Sharmila Majumdar, Nancy E Lane, Michael C Nevitt, Charles E McCulloch, Thomas M Link
OBJECTIVE: To assess (i) the impact of changes in body weight on changes in joint-adjacent subcutaneous fat (SCF) and cartilage thickness over 4-years and (ii) the relation between changes in joint-adjacent SCF and knee cartilage thickness. DESIGN: Individuals from the Osteoarthritis Initiative (total=399) with >10% weight gain (n=100) and >10% weight loss (n=100) over 4 years were compared to a matched control cohort with less than 3% change in weight (n=199)...
August 11, 2023: Osteoarthritis and Cartilage
#35
JOURNAL ARTICLE
Simon Thebault, Stephanie Gandelman, Camryn Lane, Erin J Kim, Caitlin Pileggi, Leah Zuroff, Luana D Yamashita, Matthew K Schindler, Charles Chiu, Michael R Wilson, Joseph R Berger, Clyde Markowitz, Amit Bar-Or, Ryan Fuller, Rachel Brandstadter, Amy A Pruitt, Dina A Jacobs
OBJECTIVES: The objective of this study was to report on the development of neuroinvasive West Nile virus (WNV) infection in the context of anti-CD20 monotherapy for multiple sclerosis (MS). METHODS: This is a case series study. RESULTS: In 2021-2022, we observed 4 cases of neuroinvasive WNV infection in our patient population of 2009 patients with MS on ocrelizumab, compared with a total of 46 cases of neuroinvasive WNV infection reported in Pennsylvania and 40 in New Jersey...
September 2023: Neurology® Neuroimmunology & Neuroinflammation
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JOURNAL ARTICLE
Irma M Vlasac, Gregory W Bormes, Elizabeth Do, Selma S Benkhoukha, Naby Diallo, Noah L Fryou, Siena Gioia, Oluwaseun Akeju, Clarence Joseph, Anne Kuan, Jennifer Lapan, David Oluwadara, The Pepper Team, Shadab A Rahman, Richa Saxena, Frank A J L Scheer, M Brandon Westover, John W Winkelman, Faraji Woodson, Jacqueline M Lane
The Circadia Study (Circadia) is a novel "direct-to-participant" research study investigating the genetics of circadian rhythm disorders of advanced and delayed sleep phase and non-24 hour rhythms. The goals of the Circadia Study are twofold: (i) to create an easy-to-use toolkit for at-home circadian phase assessment for patients with circadian rhythm disorders through the use of novel in-home based surveys, tests, and collection kits; and (ii) create a richly phenotyped patient resource for genetic studies that will lead to new genetic loci associated with circadian rhythm disorders revealing possible loci of interest to target in the development of therapeutics for circadian rhythm disorders...
August 9, 2023: Sleep
#37
JOURNAL ARTICLE
Joseph C Brinkman, Kade S McQuivey, Jeffrey D Hassebrock, M Lane Moore, Jordan R Pollock, John M Tokish
PURPOSE: To quantify and analyze public interest trends in platelet-rich plasma (PRP) therapy for shoulder pathology between 2011 and 2020 using Google Trends data. METHODS: Google Trends data were queried for online search data ranging from January 2011 to December 2020. Various combinations of terms related to PRP and shoulder pathology were queried. Terms related to corticosteroid therapy in association with shoulder pathology were also generated for comparative analysis...
August 2023: Arthroscopy, sports medicine, and rehabilitation
#38
JOURNAL ARTICLE
Joseph M Lane, Witchaporn Witayakom
No abstract text is available yet for this article.
July 20, 2023: Journal of Bone and Joint Surgery. American Volume
#39
JOURNAL ARTICLE
Mikita Fuchita, Jack Pattee, Derek W Russell, Brian E Driver, Matthew E Prekker, Christopher R Barnes, Joseph M Brewer, Kevin C Doerschug, John P Gaillard, Sheetal Gandotra, Shekhar Ghamande, Kevin W Gibbs, Christopher G Hughes, David R Janz, Akram Khan, Steven H Mitchell, David B Page, Todd W Rice, Wesley H Self, Lane M Smith, Susan B Stempek, Stacy A Trent, Derek J Vonderhaar, Jason R West, Micah R Whitson, Kayla Williamson, Matthew W Semler, Jonathan D Casey, Adit A Ginde
UNLABELLED: Hypotension affects approximately 40% of critically ill patients undergoing emergency intubation and is associated with an increased risk of death. The objective of this study was to examine the association between prophylactic vasopressor administration and the incidence of peri-intubation hypotension and other clinical outcomes. DESIGN: A secondary analysis of two multicenter randomized clinical trials. The clinical effect of prophylactic vasopressor administration was estimated using a one-to-one propensity-matched cohort of patients with and without prophylactic vasopressors...
July 2023: Critical care explorations
#40
JOURNAL ARTICLE
Sayi P Boddu, Vikram S Gill, M Lane Moore, Jack M Haglin, Cara H Lai, Joseph C Brinkman, Anikar Chhabra
BACKGROUND: There is a wide range of literature on patellar tendon injury, making it increasingly difficult to stay informed on the most influential studies in this field. It is essential to be familiar with the foundational articles of patellar tendon injury research to understand the current state of the literature and deliver high quality care. PURPOSE: To objectively identify the 50 most influential articles relating to patellar tendon injury and conduct a bibliometric analysis to identify key features of these articles...
July 2023: Orthopaedic Journal of Sports Medicine
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