Yan Liu, Jian Wang, Jun-Bao Huang, Xiang-Fei Li, Yu Chen, Kun Liu, Ming Zhao, Xi-Lin Huang, Xu-Li Gao, Ya-Ni Luo, Wei Tao, Jing Wu, Zheng-Lian Xue
Vitamin K2 (menaquinone, VK2 , MK) is an essential lipid-soluble vitamin that plays critical roles in inhibiting cell ferroptosis, improving blood clotting, and preventing osteoporosis. The increased global demand for VK2 has inspired interest in novel production strategies. In this review, various novel metabolic regulation strategies, including static and dynamic metabolic regulation, are summarized and discussed. Furthermore, the advantages and disadvantages of both strategies are analyzed in-depth to highlight the bottlenecks facing microbial VK2 production on an industrial scale...
November 8, 2023: World Journal of Microbiology & Biotechnology