Daria Chestnykh, Fabian Graßl, Canice Pfeifer, Jonas Dülk, Chiara Ebner, Mona Walters, Stephan von Hörsten, Johannes Kornhuber, Liubov S Kalinichenko, Markus Heinrich, Christian P Müller
RATIONALE: The dopamine D4 receptors (DRD4) play a key role in numerous brain functions and are involved in the pathogenesis of various psychiatric disorders. DRD4 ligands have been shown to moderate anxiety, reward and depression-like behaviours, and cognitive impairments. Despite a series of promising but ambiguous findings, the therapeutic advantages of DRD4 stimulation remain elusive. OBJECTIVES: The investigation focused on the behavioural effects of the recently developed DRD4 agonist, APH199, to evaluate its impact on anxiety, anhedonia, behavioural despair, establishment and retrieval of alcohol reinforcement, and amphetamine (AMPH)-induced symptoms...
February 28, 2023: Psychopharmacology