Supriya Ramesha, Sruti Rayaprolu, Christine A Bowen, Cynthia R Giver, Sara Bitarafan, Hai M Nguyen, Tianwen Gao, Michael J Chen, Ngozi Nwabueze, Eric B Dammer, Amanda K Engstrom, Hailian Xiao, Andrea Pennati, Nicholas T Seyfried, David J Katz, Jacques Galipeau, Heike Wulff, Edmund K Waller, Levi B Wood, Allan I Levey, Srikant Rangaraju
Kv1.3 potassium channels, expressed by proinflammatory central nervous system mononuclear phagocytes (CNS-MPs), are promising therapeutic targets for modulating neuroinflammation in Alzheimer's disease (AD). The molecular characteristics of Kv1.3-high CNS-MPs and their cellular origin from microglia or CNS-infiltrating monocytes are unclear. While Kv1.3 blockade reduces amyloid beta (Aβ) burden in mouse models, the downstream immune effects on molecular profiles of CNS-MPs remain unknown. We show that functional Kv1...
March 16, 2021: Proceedings of the National Academy of Sciences of the United States of America