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EDITORIAL
Mohammed Abrahim
Gout, one of the most ancient documented diseases in history, has long captivated artists, yielding a rich collection of artworks. This interest peaked during the Enlightenment era in Europe, a time marked by a surge in gout cases alongside rising wealth, consumerism, and subsequent increased public access to artists. This editorial aims to highlight an intriguing observation of a novel association within several Enlightenment-era paintings depicting individuals suffering from gout and often also portraying the distinctive red noses and cheeks seen in patients with rosacea...
January 2024: Curēus
#2
JOURNAL ARTICLE
Ernesto Damiani, Francesco M Galassi, Martina Elice
Current scientific literature often defines gout as morbus dominorum, in agreement with the Greek-Roman representation of podagra (ποδάγρα, literally "foot-trap") as a consequence of gluttony and libertinage. Several authors place the origins of this expression with the Roman writer Suetonius, without however quoting any specific primary source. We have investigated this problem again and scrutinized primary sources ranging from the Roman World to the early Middle Ages...
September 6, 2023: Clinical Rheumatology
#3
REVIEW
Werner A Golder
BACKGROUND: The case histories in the writings of the Greco-Roman physician Galen of Pergamum have so far been interpreted primarily in literary and socio-historic terms. Analysis focused on the medical aspects is still incomplete. QUESTION: Which competence for the treatment of inflammatory diseases of the musculoskeletal system do the Galenic case reports communicate? STUDY DESIGN AND RESEARCH METHODS: The 358 Galenic case histories were studied for anamnestic, clinical, therapeutic, and epidemiological statements on inflammatory diseases of the musculoskeletal system...
July 25, 2023: Orthopadie (Heidelb)
#4
JOURNAL ARTICLE
S V Guliaev, N V Chebotareva, S V Moiseev
Gout (podagra) is one of the most ancient articular diseases. Its accurate mechanisms and causes were delineated only during the last century. Major historical investigatory steps are described in relation to causality and pathogenesis of the disease from Hippocrates ages till the modern time. The newest genetic and epidemiologic aspects of the disease are presented in this article.
January 16, 2023: Terapevticheskiĭ Arkhiv
#5
Jonathan Light, Laurie L Wellman, Richard M Conran
No abstract text is available yet for this article.
2023: Academic Pathology
#6
Vellanki Sravan, Swaroop Solunke, Rushikesh Abhyankar, Vinod Nair
Gout is a crystal deposition disorder caused due to the deposition of monosodium urate crystals in joints and other tissues secondary to hyperuricemia. Podagra is the term for gout of the first metatarsophalangeal joint. In our case report, a 30-year-old male patient came to our OPD with complaints of swelling over the first metatarsophalangeal joint for one year, which was insidious in onset, localized, and had a sudden increase in size over the past three months. The patient also complained of an inability to properly wear his shoe...
December 2022: Curēus
#7
JOURNAL ARTICLE
Richard E Kast
This paper presents remarkably uniform data showing that higher NLR is a robust prognostic indicator of shorter overall survival across the common metastatic cancers. Myeloid derived suppressor cells, the NLRP3 inflammasome, neutrophil extracellular traps, and absolute neutrophil count tend to all be directly related to the NLR. They, individually and as an ensemble, contribute to cancer growth and metastasis. The multidrug regimen presented in this paper, TICO, was designed to decrease the NLR with potential to also reduce the other neutrophil related elements favoring malignant growth...
October 10, 2022: Cancers
#8
JOURNAL ARTICLE
Jenna M Dittmar, Piers D Mitchell, Peter M Jones, Bram Mulder, Sarah A Inskip, Craig Cessford, John E Robb
OBJECTIVE: To estimate the prevalence rate of gout and to explore the social factors that contributed to its development in the various sub-populations in medieval Cambridge. MATERIALS: 177 adult individuals from four medieval cemeteries located in and around Cambridge, UK. METHODS: Lesions were assessed macroscopically and radiographically. Elements with lytic lesions were described and imaged using micro-computed tomography (μCT) to determine their morphology...
June 2021: International Journal of Paleopathology
#9
JOURNAL ARTICLE
Pankaj Bansal, Andrew R Virata
No abstract text is available yet for this article.
October 2020: Arthritis & Rheumatology
#10
JOURNAL ARTICLE
Sylvia Strobl, Christian Kremser, Mihra Taljanovic, Johann Gruber, Hannes Stofferin, Rosa Bellmann-Weiler, Andrea Sabine Klauser
OBJECTIVE. The objective of our study was to compare ultrasound (US) tophus and monosodium urate (MSU) deposit detection and US tophus size in the metatarsophalangeal (MTP) 1 joint with dual-energy CT (DECT) using two DECT postprocessing protocols in patients presenting with podagra. SUBJECTS AND METHODS. Seventy-five consecutive patients with podagra (66 men and nine women; mean age, 65.6 years; age range, 33-88 years) and 75 control subjects with MTP 1 joint osteoarthritis (49 men and 26 women; mean age, 63...
December 2019: AJR. American Journal of Roentgenology
#11
JOURNAL ARTICLE
Mohanad M Elfishawi, Nour Zleik, Zoran Kvrgic, Clement J Michet, Cynthia S Crowson, Eric L Matteson, Tim Bongartz
OBJECTIVE: To examine whether a change in the presentation of incident gout happened over the last 20 years and to determine the risk of subsequent gout flares after an initial gout attack. METHODS: All incident cases of gout were identified among residents of Olmsted County, Minnesota diagnosed in 1989-1992 and 2009-2010 according to the earliest date fulfilling the 1977 American Rheumatism Association preliminary criteria, New York or Rome criteria for gout. Patients in both cohorts were then followed for up to five years...
July 15, 2019: Journal of Rheumatology
#12
JOURNAL ARTICLE
Frank Ursin, Florian Steger
OBJECTIVES: In Antiquity, colchicine was used as a poison and as a remedy for Podagra. Research so far has revealed that the physician Alexander of Tralles was the first who used it in the 6th century AD. Alexander recommended a plant he called "Hermodaktylon", which takes off the pain in the feet immediately. "Hermodaktylon" is identified with Colchicum autumnale L., which contains colchicine in his bulbs and seeds. We will present new data that varieties of Colchicum were used for medical treatment of Podagra far earlier than hitherto known by research...
July 2019: Clinical and Experimental Rheumatology
#13
JOURNAL ARTICLE
Bettina Engel, Sylvia Schacher, Klaus Weckbecker, Annika Stausberg, Ingo Gräff
BACKGROUND: Gout or hyperuricemia are both well known and common diseases. The prevalence of gout is increasing worldwide. Thus, patients with gout are becoming more common. Although there are several published guidelines for the management of gout, actual treatment of gout is inconsistent with these guidelines in many respects. Gout is usually treated by general practitioners (GP) in Germany. The aim of our study was to show which patients present to the emergency department and to record how treatment and clinical diagnostic testing of gout patients is performed in the emergency department of a university hospital in Germany...
July 9, 2018: Zeitschrift Für Orthopädie und Unfallchirurgie
#14
JOURNAL ARTICLE
David Bursill, William J Taylor, Robert Terkeltaub, Masanari Kuwabara, Tony R Merriman, Rebecca Grainger, Carlos Pineda, Worawit Louthrenoo, N Lawrence Edwards, Mariano Andrés, Ana Beatriz Vargas-Santos, Edward Roddy, Tristan Pascart, Ching-Tsai Lin, Fernando Perez-Ruiz, Sara K Tedeschi, Seoyoung C Kim, Leslie R Harrold, Geraldine McCarthy, Nitin Kumar, Peter T Chapman, Anne-Kathrin Tausche, Janitzia Vazquez-Mellado, Marwin Gutierrez, Geraldo da Rocha Castelar-Pinheiro, Pascal Richette, Eliseo Pascual, Mark C Fisher, Ruben Burgos-Vargas, Philip C Robinson, Jasvinder A Singh, Tim L Jansen, Kenneth G Saag, Ole Slot, Tillmann Uhlig, Daniel H Solomon, Robert T Keenan, Carlo Alberto Scire, Edyta Biernat-Kaluza, Mats Dehlin, George Nuki, Naomi Schlesinger, Matthijs Janssen, Lisa K Stamp, Francisca Sivera, Anthony M Reginato, Lennart Jacobsson, Frédéric Lioté, Hang-Korng Ea, Ann Rosenthal, Thomas Bardin, Hyon K Choi, Michael S Hershfield, Christine Czegley, Sung Jae Choi, Nicola Dalbeth
OBJECTIVE: The language currently used to describe gout lacks standardization. The aim of this project was to develop a consensus statement on the labels and definitions used to describe the basic disease elements of gout. METHODS: Experts in gout (n = 130) were invited to participate in a Delphi exercise and face-to-face consensus meeting to reach consensus on the labeling and definitions for the basic disease elements of gout. Disease elements and labels in current use were derived from a content analysis of the contemporary medical literature, and the results of this analysis were used for item selection in the Delphi exercise and face-to-face consensus meeting...
March 2019: Arthritis Care & Research
#15
JOURNAL ARTICLE
Gregory Tsoucalas, Theodoros Papaioannou, George Panayiotakopoulos, Zenia Saridaki, Dimitrios A Vrachatis, Marianna Karamanou
The plants of the Colchicum family were known during the archaic period in Greece for their deleterious properties. Later on, they were used for the treatment of podagra. The treatment was introduced by the ancient Greek physicians and passed on to the Byzantine and Arabian physicians to endure until nowadays. The first plant was most probably named "Medea" from the notorious Colchican witch. As the most common member of the family blossoms in autumn, the plant was named Colchicum autumnale. Various nominations were also used, such as Ephemeron, Hermodactyl, Anima articulorum and Surugen...
2018: Current Pharmaceutical Design
#16
REVIEW
Abhishek Abhishek, Edward Roddy, Michael Doherty
Gout is the most prevalent inflammatory arthritis and affects 2.5% of the general population in the UK. It is also the only arthritis that has the potential to be cured with safe, inexpensive and well tolerated urate-lowering treatments, which reduce serum uric acid by either inhibiting xanthine oxidase - eg allopurinol, febuxostat - or by increasing the renal excretion of uric acid. Of these, xanthine oxidase inhibitors are used first line and are effective in 'curing' gout in the vast majority of patients...
February 2017: Clinical Medicine: Journal of the Royal College of Physicians of London
#17
JOURNAL ARTICLE
Jae-Heung Cho, Jae Young Jung
This study aims to address questions regarding the translation of 'gout' into 'tongfeng ()' in East Asia. To this end, the formation process of the origins, 'gout' from Western medicine and 'tongfeng' from Oriental medicine, and the translational process were investigated through the relevant records and literature dating from the 16th century on. Symptoms associated with gout were originally mentioned in ancient Egypt and various terminologies were used to refer to gout, such as podagra, cheiragra and gonogra...
August 2015: Ŭi Sahak
#18
JOURNAL ARTICLE
Tomáš Alušík, Štefan Alušík
Gout is a very old disease, which exists for thousands of years. The first descriptions interpreted as the symptoms of gout can be found already in the Egyptian medical papyri dating to the 3rd mill. BC. In the Ancient world, many physicians dealt with the causes, diagnostics and the treatments of gout, such as Hippocrates of Cos, Diocles of Carystus or Claudios Galenos. A personified gout (as the goddess Podagra) is also to be found in the Ancient mythology and culture. Several human remnants of the people suffering from gout are preserved from the Antiquity as well...
2015: Casopís Lékar̆ů C̆eských
#19
JOURNAL ARTICLE
#20
JOURNAL ARTICLE
Jasvinder A Singh
INTRODUCTION: The aim of this study was to assess the accuracy of Veterans Affairs (VA) databases for gout-related health care utilization. METHODS: This retrospective study utilized VA administrative and clinical databases. A random sample of gout patients with visits (outpatient, inpatient or emergent/urgent care) with or without the diagnosis of gout (International Classification of Diseases, ninth revision, common modification ICD-9-CM code of 274.x or 274.xx) at the Birmingham VA hospital was selected...
2013: Arthritis Research & Therapy
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