V Seitz, K Gennermann, S Elezkurtaj, D Groth, S Schaper, A Dröge, N Lachmann, E Berg, D Lenze, A A Kühl, C Husemann, K Kleo, D Horst, V Lennerz, S Hennig, M Hummel, M Schumann
Celiac disease (CeD) is an autoimmune disorder affecting the small intestine with gluten as disease trigger. Infections including Influenza A, increase the CeD risk. While gluten-specific CD4+ T-cells, recognizing HLA-DQ2/DQ8 presented gluten-peptides, initiate and sustain the celiac immune response, CD8+ α/β intraepithelial T-cells elicit mucosal damage. Here, we subjected TCRs from a cohort of 56 CeD patients and 22 controls to an analysis employing 749 published CeD-related TCRβ-rearrangements derived from gluten-specific CD4+ T-cells and gluten-triggered peripheral blood CD8+ T-cells...
September 26, 2023: Clinical Immunology: the Official Journal of the Clinical Immunology Society