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JOURNAL ARTICLE
Hao Zhou, Wenkan Zhang, Hengyuan Li, Fan Xu, Eloy Yinwang, Yucheng Xue, Tao Chen, Shengdong Wang, Zenan Wang, Hangxiang Sun, Fangqian Wang, Haochen Mou, Minjun Yao, Xupeng Chai, Jiahao Zhang, Mohamed Diaty Diarra, Binghao Li, Changqing Zhang, Junjie Gao, Zhaoming Ye
Bone is one of the most common sites of tumor metastases. During the last step of bone metastasis, cancer cells colonize and disrupt the bone matrix, which is maintained mainly by osteocytes, the most abundant cells in the bone microenvironment. However, the role of osteocytes in bone metastasis is still unclear. Here, we demonstrated that osteocytes transfer mitochondria to metastatic cancer cells and trigger the cGAS/STING-mediated antitumor response. Blocking the transfer of mitochondria by specifically knocking out mitochondrial Rho GTPase 1 ( Rhot1 ) or mitochondrial mitofusin 2 ( Mfn2 ) in osteocytes impaired tumor immunogenicity and consequently resulted in the progression of metastatic cancer toward the bone matrix...
January 19, 2024: Science Advances
#22
JOURNAL ARTICLE
Na Li, Qiu-Xiao Zhu, Gui-Zhi Li, Ting Wang, Hong Zhou
BACKGROUND: Diabetic cardiomyopathy (DCM) increases the risk of hospitalization for heart failure (HF) and mortality in patients with diabetes mellitus. However, no specific therapy to delay the progression of DCM has been identified. Mitochondrial dysfunction, oxidative stress, inflammation, and calcium handling imbalance play a crucial role in the pathological processes of DCM, ultimately leading to cardiomyocyte apoptosis and cardiac dysfunctions. Empagliflozin, a novel glucose-lowering agent, has been confirmed to reduce the risk of hospitalization for HF in diabetic patients...
December 15, 2023: World Journal of Diabetes
#23
JOURNAL ARTICLE
Paul Doniol-Valcroze, Paul Coiffard, Per Alstrm, Magnus Robb, Paul Dufour, Pierre-Andr Crochet
The Buff-bellied Pipit Anthus rubescens comprises two allopatric subspecies groups: A. r. rubescens and A. r. alticola in North America and A. [r.] japonicus in north-east Asia. Despite their great morphological resemblance in breeding plumage, most individuals can be assigned to one or the other subspecies group in non-breeding plumage. Allopatric distributions, morphological differentiation and previously reported molecular divergence suggested the need for additional taxonomic study to assess the rank of these two populations...
September 7, 2023: Zootaxa
#24
JOURNAL ARTICLE
Jumee Kim, Eun-Ji Kwon, Yun-Jeong Kim, Dayeon Kim, Yoon-Ze Shin, Dayeon Gil, Jung-Hyun Kim, Hyoung Doo Shin, Lyoung Hyo Kim, Mi-Ok Lee, Young-Hyun Go, Hyuk-Jin Cha
During in vitro culture, human pluripotent stem cells (hPSCs) often acquire survival advantages characterized by decreased susceptibility to mitochondrial cell death, known as "culture adaptation." This adaptation is associated with genetic and epigenetic abnormalities, including TP53 mutations, copy number variations, trisomy, and methylation changes. Understanding the molecular mechanisms underlying this acquired survival advantage is crucial for safe hPSC-based cell therapies. Through transcriptome and methylome analysis, we discovered that the epigenetic repression of CHCHD2, a mitochondrial protein, is a common occurrence during in vitro culture using enzymatic dissociation...
January 12, 2024: Cellular and Molecular Life Sciences: CMLS
#25
JOURNAL ARTICLE
Lindsay A Bischoff, Ian Ganly, Laura Fugazzola, Erin Buczek, William C Faquin, Bryan R Haugen, Bryan McIver, Caitlin P McMullen, Kate Newbold, Daniel J Rocke, Marika D Russell, Mabel Ryder, Peter M Sadow, Eric Sherman, Maisie Shindo, David C Shonka, Michael C Singer, Brendan C Stack, Lori J Wirth, Richard J Wong, Gregory W Randolph
IMPORTANCE: Oncocytic (Hürthle cell) thyroid carcinoma is a follicular cell-derived neoplasm that accounts for approximately 5% of all thyroid cancers. Until recently, it was categorized as a follicular thyroid carcinoma, and its management was standardized with that of other differentiated thyroid carcinomas. In 2022, given an improved understanding of the unique molecular profile and clinical behavior of oncocytic thyroid carcinoma, the World Health Organization reclassified oncocytic thyroid carcinoma as distinct from follicular thyroid carcinoma...
January 11, 2024: JAMA Otolaryngology—Head & Neck Surgery
#26
JOURNAL ARTICLE
Chenhao Gao, Junkui Shang, Zhengyu Sun, Mingrong Xia, Dandan Gao, Ruihua Sun, Wei Li, Fengyu Wang, Jiewen Zhang
Alzheimer's disease (AD) is an age-related progressive neurodegenerative disease, and approximately 10% of AD cases are early-onset familial AD (EOFAD), which is mainly linked to point mutations in genes encoding presenilins (PS1 and PS2). Mutations in PS2 are extremely rare and have not received enough attention. Recently, studies have found that Rho GTPase activity is closely related to the pathogenesis of AD. In this study, we used transcriptome sequencing in PS2 siRNA-transfected SH-SY5Y cells and found a group of differentially expressed genes (DEGs) related to the regulation of GTPase activity...
December 30, 2023: Molecular Neurobiology
#27
JOURNAL ARTICLE
Elena Yu Potapenko, Nataliia D Kashko, Dmitry A Knorre
In a eukaryotic cell, the ratio of mitochondrial DNA (mtDNA) to nuclear DNA (nDNA) is usually maintained within a specific range. This suggests the presence of a negative feedback loop mechanism preventing extensive mtDNA replication and depletion. However, the experimental data on this hypothetical mechanism are limited. In this study, we suggested that deletions in mtDNA, known to increase mtDNA abundance, can disrupt this mechanism, and thus, increase cell-to-cell variance in the mtDNA copy numbers. To test this, we generated Saccharomyces cerevisiae rho- strains with large deletions in the mtDNA and rho0 strains depleted of mtDNA...
December 12, 2023: International Journal of Molecular Sciences
#28
JOURNAL ARTICLE
Selina Carlhoff, Wibhu Kutanan, Adam B Rohrlach, Cosimo Posth, Mark Stoneking, Kathrin Nägele, Rasmi Shoocongdej, Johannes Krause
The Iron Age of highland Pang Mapha, northwestern Thailand, is characterised by a mortuary practice known as Log Coffin culture. Dating between 2300 and 1000 years ago, large coffins carved from individual teak trees have been discovered in over 40 caves and rock shelters. While previous studies focussed on the cultural development of the Log Coffin-associated sites, the origins of the practice, connections with other wooden coffin-using groups in Southeast Asia, and social structure within the region remain understudied...
December 22, 2023: Nature Communications
#29
JOURNAL ARTICLE
Ivan A Dvoyashov, Semyon Yu Bodrov, Nikolai V Mamaev, Elena S Glagoleva, Natalia I Abramson
The subgenus Aschizomys belongs to the genus Alticola (Central Asian mountain vole) and consists of two species: Alticola macrotis and Alticola lemminus. Phylogenetic relationships within the subgenus Aschizomys remain obscure due to limited sampling, an insufficient number of molecular markers used in phylogenetic studies, and paraphyly observed on mitochondrial trees. In this work, to infer reliable phylogenetic relationships and evaluate putative scenarios of ancient hybridization within the subgenus, we applied double-digest restriction site-associated DNA paired-end (quaddRAD) sequencing to 20 DNA samples (20 individuals), including five species of the genus Alticola , and dated the divergence of cytochrome b ( cytb ) lineages within Aschizomys using a "second calibration" approach...
December 2023: Ecology and Evolution
#30
JOURNAL ARTICLE
Yu-Xiang Lin, Jun-Yong Pan, Wen-Du Feng, Tian-Cong Huang, Cheng-Zong Li
BACKGROUND: Hepatocellular carcinoma (HCC) is one of the most prevalent forms of cancer and poses a threat to the health and survival of humans. Mitochondrial ribosomal protein L48 (MRPL48) belongs to the mitochondrial ribosomal protein family, which participates in energy production. Studies have shown that MRPL48 can predict osteosarcoma incidence and prognosis, as well as promotes colorectal cancer progression. However, the role of MRPL48 in HCC remains unknown. METHODS: TCGA, GEO, HCCDB, CPTAC, SMART, UALCAN, Kaplan-Meier plotter, cBioPortal, and MethSurv were performed for bioinformatics purposes...
December 14, 2023: European Journal of Medical Research
#31
JOURNAL ARTICLE
Logan R Timmins, Milene Ortiz-Silva, Bharat Joshi, Y Lydia Li, Fiona H Dickson, Timothy H Wong, Kurt R Vandevoorde, Ivan R Nabi
Caveolin-1 (CAV1), the main structural component of caveolae, is phosphorylated at tyrosine-14 (pCAV1), regulates signal transduction, mechanotransduction, and mitochondrial function, and plays contrasting roles in cancer progression. We report that CRISPR/Cas9 knockout (KO) of CAV1 increases mitochondrial oxidative phosphorylation, increases mitochondrial potential, and reduces ROS in MDA-MB-231 triple-negative breast cancer cells. Supporting a role for pCAV1, these effects are reversed upon expression of CAV1 phosphomimetic CAV1 Y14D but not non-phosphorylatable CAV1 Y14F...
January 2024: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
#32
JOURNAL ARTICLE
Chao Wu, Haoran Yin, Songdi Fu, Hanna Yoo, Min Zhang, Hyokeun Park
Huntington's disease (HD) is a progressive genetic neurodegenerative disease caused by an abnormal expansion of a cytosine-adenine-guanine trinucleotide repeat in the huntingtin gene. One pathological feature of HD is neuronal loss in the striatum. Despite many efforts, mechanisms underlying neuronal loss in HD striatum remain elusive. It was suggested that the mutant huntingtin protein interacts mitochondrial proteins and causes mitochondrial dysfunction in striatal neurons. However, whether axonal transport of mitochondria is altered in HD striatal neurons remains controversial...
November 18, 2023: Biochemical and Biophysical Research Communications
#33
JOURNAL ARTICLE
Hisakatsu Sone, Tae Jin Lee, Byung Rho Lee, Dan Heo, Sekyung Oh, Sang-Ho Kwon
Chronic kidney disease can develop from kidney injury incident to chemotherapy with cisplatin, which complicates the prognosis of cancer patients. MicroRNAs regulate gene expression by pairing with specific sets of messenger RNAs. Therefore, elucidating direct physical interactions between microRNAs and their target messenger RNAs can help decipher crucial biological processes associated with cisplatin-induced kidney injury. Through intermolecular ligation and transcriptome-wide sequencing, we here identify direct pairs of microRNAs and their target messenger RNAs in the kidney of male mice injured by cisplatin...
November 28, 2023: Nature Communications
#34
JOURNAL ARTICLE
Dominic Lenz, Lea D Schlieben, Masaru Shimura, Alyssa Bianzano, Dmitrii Smirnov, Robert Kopajtich, Riccardo Berutti, Rüdiger Adam, Denise Aldrian, Ivo Baric, Ulrich Baumann, Neslihan Eksi Bozbulut, Melanie Brugger, Theresa Brunet, Philip Bufler, Birutė Burnytė, Pier Luigi Calvo, Ellen Crushell, Buket Dalgıç, Anibh M Das, Antal Dezsőfi, Felix Distelmaier, Alexander Fichtner, Peter Freisinger, Sven F Garbade, Harald Gaspar, Louise Goujon, Nedim Hadzic, Steffen Hartleif, Bianca Hegen, Maja Hempel, Stephan Henning, Andre Hoerning, Roderick Houwen, Joanne Hughes, Raffaele Iorio, Katarzyna Iwanicka-Pronicka, Martin Jankofsky, Norman Junge, Ino Kanavaki, Aydan Kansu, Sonja Kaspar, Simone Kathemann, Deidre Kelly, Ceyda Tuna Kırsaçlıoğlu, Birgit Knoppke, Martina Kohl, Heike Kölbel, Stefan Kölker, Vassiliki Konstantopoulou, Tatiana Krylova, Zarife Kuloğlu, Alice Kuster, Martin W Laass, Elke Lainka, Eberhard Lurz, Hanna Mandel, Katharina Mayerhanser, Johannes A Mayr, Patrick McKiernan, Patricia McLean, Valerie McLin, Karine Mention, Hanna Müller, Laurent Pasquier, Martin Pavlov, Natalia Pechatnikova, Bianca Peters, Danijela Petković Ramadža, Dorota Piekutowska-Abramczuk, Denisa Pilic, Sanjay Rajwal, Nathalie Rock, Agnès Roetig, René Santer, Wilfried Schenk, Natalia Semenova, Christiane Sokollik, Ekkehard Sturm, Robert W Taylor, Eva Tschiedel, Vaidotas Urbonas, Roser Urreizti, Jan Vermehren, Jerry Vockley, Georg-Friedrich Vogel, Matias Wagner, Wendy van der Woerd, Saskia B Wortmann, Ekaterina Zakharova, Georg Friedrich Hoffmann, Thomas Meitinger, Kei Murayama, Christian Staufner, Holger Prokisch
BACKGROUND AIMS: Pediatric acute liver failure (PALF) is a life-threatening condition. In Europe, main causes are viral infections (12-16%) and inherited metabolic diseases (14-28%). Yet, in up to 50% of cases the underlying etiology remains elusive, challenging clinical management, including liver transplantation. We systematically studied indeterminate PALF cases referred for genetic evaluation by whole-exome sequencing (WES), and analyzed phenotypic and biochemical markers, and the diagnostic yield of WES in this condition...
November 17, 2023: Hepatology: Official Journal of the American Association for the Study of Liver Diseases
#35
JOURNAL ARTICLE
Xuefeng Fang, Dong Dong, Mei Yang, Xinzheng Li
Petrolisthes lamarckii (Leach, 1821) and P. haswelli Miers, 1884 are a pair of sister species of porcelain crabs, both of which are common in the intertidal zone of southern China, typically found under rocks and in the crevices of coral reefs. However, the distribution, genetic relationship and diversity of the two species in China have not been rigorously studied. Meanwhile, P. lamarckii is considered as a complex of cryptic species due to their diverse morphological features. In this study, we identified 127 specimens of the P...
October 31, 2023: International Journal of Molecular Sciences
#36
JOURNAL ARTICLE
Elana E Baltrusaitis, Erika E Ravitch, Adam R Fenton, Tania Perez, Erika L F Holzbaur, Roberto Dominguez
MIRO (mitochondrial Rho GTPase) consists of two GTPase domains flanking two Ca2+ -binding EF-hand domains. A C-terminal transmembrane helix anchors MIRO to the outer mitochondrial membrane, where it functions as a general adaptor for the recruitment of cytoskeletal proteins that control mitochondrial dynamics. One protein recruited by MIRO is TRAK (trafficking kinesin-binding protein), which in turn recruits the microtubule-based motors kinesin-1 and dynein-dynactin. The mechanism by which MIRO interacts with TRAK on the mitochondrial membrane is not well understood...
November 8, 2023: Journal of Biological Chemistry
#37
JOURNAL ARTICLE
Jiarui Zhang, Li Gong, Huayu Zhu, Wei Sun, Jing Tian, Yan Zhang, Qiao Liu, Xiaolan Li, Fuqin Zhang, Shumei Wang, Shaojun Zhu, Dongjing Ding, Wei Zhang, Chen Yang
Epilepsy, a common complication of diffuse low-grade gliomas (DLGGs; diffuse oligodendroglioma and astrocytoma collectively), severely compromises the quality of life of patients. DLGG epileptogenicity may primarily be generated by interactions between the tumor and the neocortex. Neuronal uptake of dysfunctional mitochondria from the extracellular environment can lead to abnormal neuronal discharge. Mitochondrial dysfunction is frequently observed in gliomas that can transmigrate across the plasma membranes...
November 3, 2023: Neurobiology of Disease
#38
JOURNAL ARTICLE
B Sanchez-Lechuga, M Salvucci, N Ng, B Kinsley, M Hatunic, M Kennelly, J Edwards, A Fleming, B Byrne, M M Byrne
AIMS: The most common pathogenic mitochondrial mutation associated with mitochondrial disease is m.3243A>G. Increased obstetric complications, such as spontaneous abortion, gestational diabetes (GDM), preterm delivery, and preeclampsia, have been reported in women carrying this mutation. We aimed to determine the fetal and maternal outcomes in pregnant women with mitochondrial disease. METHODS: We retrospectively studied the obstetric and perinatal outcomes in 88 pregnancies of 26 women with genetically confirmed mitochondrial disease (m...
October 31, 2023: Acta Diabetologica
#39
JOURNAL ARTICLE
Saly Sitthivong, Peter Brakels, Santi Xayyasith, Nathanaël Maury, Sabira Idiiatullina, Parinya Pawangkhanant, Kai Wang, Tan Van Nguyen, Nikolay A Poyarkov
We describe a unique new species and genus of agamid lizard from the karstic massifs of Khammouan Province, central Laos. Laodracon carsticola Gen. et sp. nov. is an elusive medium-sized lizard (maximum snout-vent length 101 mm) specifically adapted to life on limestone rocks and pinnacles. To assess the phylogenetic position of the new genus amongst other agamids, we generated DNA sequences from two mitochondrial gene fragments (16S rRNA and ND 2) and three nuclear loci ( BDNF , RAG1 and c-mos ), with a final alignment comprising 7 418 base pairs for 64 agamid species...
November 18, 2023: Zoological Research
#40
JOURNAL ARTICLE
Renato Socodato, Artur Rodrigues-Santos, Joana Tedim-Moreira, Tiago O Almeida, Teresa Canedo, Camila C Portugal, João B Relvas
Microglia are the largest myeloid cell population in the brain. During injury, disease, or inflammation, microglia adopt different functional states primarily involved in restoring brain homeostasis. However, sustained or exacerbated microglia inflammatory reactivity can lead to brain damage. Dynamic cytoskeleton reorganization correlates with alterations of microglial reactivity driven by external cues, and proteins controlling cytoskeletal reorganization, such as the Rho GTPase RhoA, are well positioned to refine or adjust the functional state of the microglia during injury, disease, or inflammation...
October 20, 2023: Cell Death & Disease
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