Rajesh Khanna, Amol Patwardhan, Xiaofang Yang, Wennan Li, Song Cai, Yingshi Ji, Lindsey A Chew, Angie Dorame, Shreya S Bellampalli, Ryan W Schmoll, Janalee Gordon, Aubin Moutal, Todd W Vanderah, Frank Porreca, Mohab M Ibrahim
We report the development and characterization of a novel, injury-free rat model in which nociceptive sensitization after red light is observed in multiple body areas reminiscent of widespread pain in functional pain syndromes. Rats were exposed to red light-emitting diodes (RLED) (LEDs, 660 nm) at an intensity of 50 Lux for 8 hours daily for 5 days resulting in time- and dose-dependent thermal hyperalgesia and mechanical allodynia in both male and female rats. Females showed an earlier onset of mechanical allodynia than males...
November 2019: Journal of Pain