Xingyi Guo, Jie Ping, Yaohua Yang, Xinwan Su, Xiao-Ou Shu, Wanqing Wen, Zhishan Chen, Yunjing Zhang, Ran Tao, Guochong Jia, Jingni He, Qiuyin Cai, Qingrun Zhang, Graham G Giles, Rachel Pearlman, Gad Rennert, Pavel Vodicka, Amanda Phipps, Stephen B Gruber, Graham Casey, Ulrike Peters, Jirong Long, Weiqiang Lin, Wei Zheng
Alternative polyadenylation (APA) modulates mRNA processing in the 3' untranslated regions (3' UTR), affecting mRNA stability and translation efficiency. Research into genetically regulated APA has the potential to provide insights into cancer risk. Herein, we conducted large alternative polyadenylation-wide association studies (APA-WAS) to investigate associations of APA levels with cancer risk. Genetic models were built to predict APA levels in multiple tissues using genotype and RNA-sequencing data from 1,337 samples from the Genotype-Tissue Expression Project...
May 17, 2024: Cancer Research