Evan N Cohen, Tamer M Fouad, Bang-Ning Lee, Banu K Arun, Diane Liu, Sanda Tin, Angelica M Gutierrez Barrera, Toshihide Miura, Iwao Kiyokawa, Jun Yamashita, Ricardo H Alvarez, Vicente Valero, Wendy A Woodward, Yu Shen, Naoto T Ueno, Massimo Cristofanilli, James M Reuben
PURPOSE: The carbohydrate sialyl LewisX (sLeX ) mediates cell adhesion, is critical in the normal function of immune cells, and is frequently over-expressed on cancer cells. We assessed the association, differential levels, and prognostic value of sLeX and inflammatory cytokines/chemokines in breast cancer sera. METHODS: We retrospectively measured sLeX and a panel of cytokines/chemokines in the sera of 26 non-invasive ductal carcinoma in situ (DCIS), 154 invasive non-metastatic breast cancer (non-MBC), 63 metastatic breast cancer (MBC) patients, and 43 healthy controls...
May 3, 2019: Breast Cancer Research and Treatment