Liesbeth Thewissen, Gunnar Naulaers, Dries Hendrikx, Alexander Caicedo, Keith Barrington, Geraldine Boylan, Po-Yin Cheung, David Corcoran, Afif El-Khuffash, Aisling Garvey, Jozef Macko, Neil Marlow, Jan Miletin, Colm P F O'Donnell, John M O'Toole, Zbyněk Straňák, David Van Laere, Hana Wiedermannova, Eugene Dempsey
BACKGROUND: The impact of the permissive hypotension approach in clinically well infants on regional cerebral oxygen saturation (rScO2 ) and autoregulatory capacity (CAR) remains unknown. METHODS: Prospective cohort study of blinded rScO2 measurements within a randomized controlled trial of management of hypotension (HIP trial) in extremely preterm infants. rScO2 , mean arterial blood pressure, duration of cerebral hypoxia, and transfer function (TF) gain inversely proportional to CAR, were compared between hypotensive infants randomized to receive dopamine or placebo and between hypotensive and non-hypotensive infants, and related to early intraventricular hemorrhage or death...
August 2021: Pediatric Research