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https://read.qxmd.com/read/32557783/promoting-dementia-awareness-in-african-american-faith-communities
#1
Fayron Epps, Karah Alexander, Glenna S Brewster, Lauren J Parker, Mia Chester, Audrey Tomlinson, Aisha Adkins, Sabrina Zingg, Jacque Thornton
INTRODUCTION: Alzheimer's disease and other dementia-related disorders are affecting the African-American community at alarming rates. African-American churches have traditionally been places of refuge where families go for support. However, many churches lack programs or resources to support families affected by dementia. In response, a nurse-led interdisciplinary collaborative partnered with churches to promote dementia awareness through education. PURPOSE: The purpose of this analysis was to (a) describe the demographics of those seeking dementia education in African-American faith communities; (b) identify prior knowledge of dementia community resources; and (c) determine the preliminary usefulness of the education provided...
June 18, 2020: Public Health Nursing
https://read.qxmd.com/read/31001580/comparative-analyses-of-plasma-amyloid-%C3%AE-levels-in-heterogeneous-and-monomerized-states-by-interdigitated-microelectrode-sensor-system
#2
YoungSoo Kim, Yong Kyoung Yoo, Hye Yun Kim, Jee Hoon Roh, Jinsik Kim, Seungyeop Baek, Jinny Claire Lee, Hye Jin Kim, Myung-Sic Chae, Dahye Jeong, Dongsung Park, Sejin Lee, HoChung Jang, Kyeonghwan Kim, Jeong Hoon Lee, Byung Hyun Byun, Su Yeon Park, Jeong Ho Ha, Kyo Chul Lee, Won Woo Cho, Jae-Seung Kim, Jae-Young Koh, Sang Moo Lim, Kyo Seon Hwang
Detection of amyloid-β (Aβ) aggregates contributes to the diagnosis of Alzheimer disease (AD). Plasma Aβ is deemed a less invasive and more accessible hallmark of AD, as Aβ can penetrate blood-brain barriers. However, correlations between biofluidic Aβ concentrations and AD progression has been tenuous. Here, we introduce a diagnostic technique that compares the heterogeneous and the monomerized states of Aβ in plasma. We used a small molecule, EPPS [4-(2-hydroxyethyl)-1-piperazinepropanesulfonic acid], to dissociate aggregated Aβ into monomers to enhance quantification accuracy...
April 2019: Science Advances
https://read.qxmd.com/read/30899050/amyloid-beta-in-nasal-secretions-may-be-a-potential-biomarker-of-alzheimer-s-disease
#3
Young Hyo Kim, Sang-Myung Lee, Sungbo Cho, Ju-Hee Kang, Yang-Ki Minn, Hyelim Park, Seong Hye Choi
We investigated the level of amyloid beta (Aβ) in nasal secretions of patients with Alzheimer's disease dementia (ADD) using interdigitated microelectrode (IME) biosensors and determined the predictive value of Aβ in nasal secretions for ADD diagnosis. Nasal secretions were obtained from 35 patients with ADD, 18 with cognitive decline associated with other neurological disorders (OND), and 26 cognitively unimpaired (CU) participants. Capacitance changes in IMEs were measured by capturing total Aβ (ΔCtAβ )...
March 21, 2019: Scientific Reports
https://read.qxmd.com/read/30639321/epps-treatment-attenuates-traumatic-brain-injury-in-mice-by-reducing-a%C3%AE-burden-and-ameliorating-neuronal-autophagic-flux
#4
Angela Melinda A Anthony Jalin, Rong Jin, Min Wang, Guohong Li
Beta-amyloid (Aβ) burden and impaired neuronal autophagy contribute to secondary brain injury after traumatic brain injury (TBI). 4-(2-hydroxyethyl)-1-piperazinepropanesulphonic acid (EPPS) treatment has been reported to reduce Aβ aggregation and rescue behavioral deficits in Alzheimer's disease-like mice. Here, we investigated neuroprotective effects of EPPS in a mouse model of TBI. Mice subjected to controlled cortical impact (CCI) were treated with EPPS (120 mg/kg, orally) immediately after CCI and thereafter once daily for 3 or 7 days...
January 9, 2019: Experimental Neurology
https://read.qxmd.com/read/30480247/atomic-force-microscopy-analysis-of-epps-driven-degradation-and-reformation-of-amyloid-%C3%AE-aggregates
#5
Wonseok Lee, Sang Won Lee, Gyudo Lee, Dae Sung Yoon
Amyloid-β (Aβ) peptides can be aggregated into β-sheet rich fibrils or plaques and deposited on the extracellular matrix of brain tissues, which is a hallmark of Alzheimer's disease. Several drug candidates have been designed to retard the progression of the neurodegenerative disorder or to eliminate toxic Aβ aggregates. Recently, 4-(2-Hydroxyethyl)-1-piperazinepropanesulfonic acid (EPPS) has emerged as a promising drug candidates for elimination of toxic Aβ aggregates. However, the effect of EPPS on the degradation of Aβ aggregates such as fibrils has not yet been fully elucidated...
February 16, 2018: JAD Reports
https://read.qxmd.com/read/30457489/-it-s-just-part-of-life-african-american-daughters-caring-for-parents-with-dementia
#6
Susan M McLennon, Joel G Anderson, Fayron Epps, Karen M Rose
The purpose of this study was to gain a greater understanding of the experiences of African American daughters caring for parents with Alzheimer's disease or a related dementia (ADRD). In this secondary analysis of a subset (N = 12) of the sample from a previous study, daughters averaged 54 years of age and were caring for parents with moderate to severe ADRD. Results revealed two main categories: Caregiver Concerns and Caregiver Coping. Subcategories included challenging behaviors, social aspects, integration, and family culture and values...
November 20, 2018: Journal of Women & Aging
https://read.qxmd.com/read/30284480/photojournalism-based-intervention-reduces-caregiver-burden-and-depression-in-alzheimer-s-disease-family-caregivers
#7
Whitney Wharton, Fayron Epps, Mariya Kovaleva, Lindsey Bridwell, Rachanice Candy Tate, Cornelya D Dorbin, Kenneth Hepburn
PURPOSE: Art interventions have demonstrated holistic benefits for persons living with dementia and their caregivers. In this article, we describe the results of a pilot photojournalism program for 10 unpaid caregivers of persons living with dementia, with respect to caregivers' experience in the program and their psychological well-being. DESIGN: Caregivers participated in four sessions led by a professional photojournalist who taught principles of photography...
October 4, 2018: Journal of Holistic Nursing: Official Journal of the American Holistic Nurses' Association
https://read.qxmd.com/read/30043638/associations-of-knowledge-of-alzheimer-s-disease-and-memory-loss-and-employment-status-with-burden-in-african-american-and-caucasian-family-caregivers
#8
Cathy B Scott, Olivio J Clay, Fayron Epps, Fawn A Cothran, Ishan C Williams
Caring for an individual living with Alzheimer's disease and other forms of dementia is especially challenging and impacts every aspect of the lives of the family caregivers. Family caregiving is defined as informal, unpaid care provided by family or friends to people with a chronic illness or disability. Caregiver burden, often experienced by a caregiver for a cognitively impaired family member, is multifaceted involving physical, psychological, social, and emotional problems. To date, little has been done to examine the relationship between the knowledge of Alzheimer's disease and memory loss and caregiver burden...
July 25, 2018: Dementia
https://read.qxmd.com/read/27919712/extracts-from-two-ubiquitous-mediterranean-plants-ameliorate-cellular-and-animal-models-of-neurodegenerative-proteinopathies
#9
Michelle Briffa, Stephanie Ghio, Johanna Neuner, Alison J Gauci, Rebecca Cacciottolo, Christelle Marchal, Mario Caruana, Christophe Cullin, Neville Vassallo, Ruben J Cauchi
A signature feature of age-related neurodegenerative proteinopathies is the misfolding and aggregation of proteins, typically amyloid-β (Aβ) in Alzheimer's disease (AD) and α-synuclein (α-syn) in Parkinson's disease (PD), into soluble oligomeric structures that are highly neurotoxic. Cellular and animal models that faithfully replicate the hallmark features of these disorders are being increasing exploited to identify disease-modifying compounds. Natural compounds have been identified as a useful source of bioactive molecules with promising neuroprotective capabilities...
January 18, 2017: Neuroscience Letters
https://read.qxmd.com/read/27855241/how-do-we-promote-health-from-the-words-of-african-american-older-adults-with-dementia-and-their-family-members
#10
Fayron Epps, Lisa Skemp, Janet K Specht
As population diversity increases, understanding what health promotion means to ethnically diverse older adults and their family members aids in the design of health programming. This understanding is particularly relevant for the African American population who experience a high prevalence of Alzheimer's disease and related dementias (ADRD). The purpose of the current study was to describe family members' definition of health, health promotion activities (HPAs), barriers to HPAs, and the perceived effectiveness of HPAs for African American older adults with ADRD...
November 1, 2016: Research in Gerontological Nursing
https://read.qxmd.com/read/27796293/rapid-and-sustained-cognitive-recovery-in-app-ps1-transgenic-mice-by-co-administration-of-epps-and-donepezil
#11
Hye Yun Kim, Hyunjin Vincent Kim, Dongkeun K Lee, Seung-Hoon Yang, YoungSoo Kim
Alzheimer's disease (AD) is a neurodegenerative disease characterized by sequential progression of pathological events, such as aggregation of amyloid-β proteins, followed by outward symptoms of cognitive impairments. Given that a combination of different therapeutic strategies often provides more rapid and effective outcomes in diverse areas of clinical treatment, we hypothesized that administration of anti-amyloid drugs with cognitive enhancers would result in synergistic effects in AD treatment. Here, we co-administered 4-(2-hydroxyethyl)-1-piperazinepropane-sulphonic acid (EPPS), an amyloid-clearing chemical, and donepezil, an acetylcholinesterase inhibitor, to determine whether they could serve complementary roles for each other in regards to AD treatment...
October 31, 2016: Scientific Reports
https://read.qxmd.com/read/27405579/automated-pet-only-quantification-of-amyloid-deposition-with-adaptive-template-and-empirically-pre-defined-roi
#12
G Akamatsu, Y Ikari, A Ohnishi, H Nishida, K Aita, M Sasaki, Y Yamamoto, M Sasaki, M Senda
Amyloid PET is useful for early and/or differential diagnosis of Alzheimer's disease (AD). Quantification of amyloid deposition using PET has been employed to improve diagnosis and to monitor AD therapy, particularly in research. Although MRI is often used for segmentation of gray matter and for spatial normalization into standard Montreal Neurological Institute (MNI) space where region-of-interest (ROI) template is defined, 3D MRI is not always available in clinical practice. The purpose of this study was to examine the feasibility of PET-only amyloid quantification with an adaptive template and a pre-defined standard ROI template that has been empirically generated from typical cases...
August 7, 2016: Physics in Medicine and Biology
https://read.qxmd.com/read/26646366/epps-rescues-hippocampus-dependent-cognitive-deficits-in-app-ps1-mice-by-disaggregation-of-amyloid-%C3%AE-oligomers-and-plaques
#13
Hye Yun Kim, Hyunjin Vincent Kim, Seonmi Jo, C Justin Lee, Seon Young Choi, Dong Jin Kim, YoungSoo Kim
Alzheimer's disease (AD) is characterized by the transition of amyloid-β (Aβ) monomers into toxic oligomers and plaques. Given that Aβ abnormality typically precedes the development of clinical symptoms, an agent capable of disaggregating existing Aβ aggregates may be advantageous. Here we report that a small molecule, 4-(2-hydroxyethyl)-1-piperazinepropanesulphonic acid (EPPS), binds to Aβ aggregates and converts them into monomers. The oral administration of EPPS substantially reduces hippocampus-dependent behavioural deficits, brain Aβ oligomer and plaque deposits, glial γ-aminobutyric acid (GABA) release and brain inflammation in an Aβ-overexpressing, APP/PS1 transgenic mouse model when initiated after the development of severe AD-like phenotypes...
December 8, 2015: Nature Communications
https://read.qxmd.com/read/16140289/isoform-specific-interactions-of-human-apolipoprotein-e-to-an-intermediate-conformation-of-human-alzheimer-amyloid-beta-peptide
#14
Nancy C Stratman, Christine K Castle, Bruce M Taylor, Dennis E Epps, George W Melchior, Donald B Carter
Brain plaque deposits of amyloid-beta peptide (Abeta) is a pathological hallmark of Alzheimer's disease (AD) and apolipoprotein E (apoE) is thought to be involved in its deposition. One hypothesis for the role of apoE in the pathogenesis of AD is that apoE may be involved in deposition or clearance of Abeta by direct protein-to-protein interaction. Lipidated apoE4 bound preferentially to an intermediate aggregated form of Abeta and formed two- to three-fold more binding complexes than isoforms apoE2 or apoE3...
October 2005: Chemistry and Physics of Lipids
https://read.qxmd.com/read/14678772/a-slowly-formed-transient-conformer-of-abeta-1-40-is-toxic-to-inward-channels-of-dissociated-hippocampal-and-cortical-neurons-of-rats
#15
Xiao-Dong Sun, Zun-Li Mo, Bruce M Taylor, Dennis E Epps
The mechanism by which amyloid peptide (Abeta(1-40)) produces effects on neurotransmission is currently unresolved. In initial experiments, using the patch-clamp technique, we found that 11.5 microM of preaggregated Abeta(1-40) altered the hippocampal neuron resting membrane potential and inhibited action potential firing. To identify the toxic species, the effects of Abeta(1-40) on sodium (I(Na)), calcium (I(Ca)), and potassium (I(K)) currents in hippocampal neurons were examined as a function of peptide aggregation state in a specially designed miniature recording chamber...
December 2003: Neurobiology of Disease
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