Man Li, Adam S Lazorchak, Xinxing Ouyang, Huihui Zhang, Hongzhi Liu, Omotooke A Arojo, Lichong Yan, Jingsi Jin, Yuheng Han, Guojun Qu, Yuhong Fu, Xiaocao Xu, Xiaobo Liu, Wenqian Zhang, Zhengfeng Yang, Chuan Ruan, Qijun Wang, Dou Liu, Chuanxin Huang, Lu Lu, Shibo Jiang, Fubin Li, Bing Su
Proper control of B cell growth and metabolism is crucial for B-cell-mediated immunity, but the underlying molecular mechanisms remain incompletely understood. In this study, Sin1, a key component of mTOR complex 2 (mTORC2), specifically regulates B cell growth and metabolism. Genetic ablation of Sin1 in B cells reduces the cell size at either the transitional stage or upon antigen stimulation and severely impairs metabolism. Sin1 deficiency also severely impairs B-cell proliferation, antibody responses, and anti-viral immunity...
January 31, 2019: Cellular & Molecular Immunology