Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
JOURNAL ARTICLE
Nazar M Shareef Mahmood, Almas Mr Mahmud, Ismail M Maulood
BACKGROUND: The pineal product melatonin (MEL) modulates blood vessels through G protein-coupled receptors (GPCRs) called melatonin type 1 receptor (MT1 R) and melatonin type 2 receptor (MT2 R), in that order. The renin-angiotensin system (RAS), which breaks down angiotensin II (Ang II) to create Ang 1-7, is thought to be mostly controlled by angiotensin-converting enzyme-2 (ACE2 ). AIM: The current work examines the involvement of ACE2 inhibitor, MEL, and ramelteon (RAM) in the vascular response to Ang II activities in the endothelial denuded (E-) and intact (E+) rat isolated thoracic aortic rings...
April 26, 2024: Journal of Receptor and Signal Transduction Research
#2
JOURNAL ARTICLE
Masahiro Takeshima, Kazuhisa Yoshizawa, Masaya Ogasawara, Mizuki Kudo, Yu Itoh, Naoko Ayabe, Kazuo Mishima
IMPORTANCE: Although insomnia guidelines recommend the use of several individual hypnotics, the most useful hypnotic for treating insomnia in a clinical setting remains unclear. OBJECTIVE: To determine which guideline-recommended hypnotics have lower risks of monotherapy failure and which hypnotics have a higher risk of long-term prescription for insomnia treatment. DESIGN, SETTING, AND PARTICIPANTS: This retrospective observational cohort study used data from the Japan Medical Data Center Claims Database from April 1, 2005, to March 31, 2021...
April 1, 2024: JAMA Network Open
#3
JOURNAL ARTICLE
Risa Hirata, Naoko E Katsuki, Hitomi Shimada, Eiji Nakatani, Kiyoshi Shikino, Chihiro Saito, Kaori Amari, Yoshimasa Oda, Midori Tokushima, Masaki Tago
PURPOSE: There has been no large-scale investigation into the association between the use of lemborexant, suvorexant, and ramelteon and falls in a large population. This study, serving as a pilot investigation, was aimed at examining the relationship between inpatient falls and various prescribed hypnotic medications at admission. PATIENTS AND METHODS: This study was a sub-analysis of a multicenter retrospective observational study conducted over a period of 3 years...
2024: International Journal of General Medicine
#4
JOURNAL ARTICLE
Motohiro Ozone, Susumu Hirota, Yu Ariyoshi, Kenichi Hayashida, Azusa Ikegami, Mitsunari Habukawa, Hayato Ohshima, Daisuke Harada, Hiroshi Hiejima, Nozomu Kotorii, Kenta Murotani, Takehiro Taninaga, Naohisa Uchimura
INTRODUCTION: For patients with chronic insomnia, conventional therapy may not always provide satisfactory efficacy and safety. Thus, switching to an alternative therapeutic agent can be explored. However, there is a lack of prospective studies evaluating the effectiveness of such changes. This prospective, non-randomized, open-label, interventional, multicenter study assessed whether Japanese patients with chronic insomnia dissatisfied with treatment could transition directly to lemborexant (LEM) from four cohorts-non-benzodiazepine sedative-hypnotic (zolpidem, zopiclone, or eszopiclone) monotherapy, dual orexin receptor antagonist (suvorexant) monotherapy, suvorexant + benzodiazepine receptor agonists (BZRAs), and melatonin receptor agonist (ramelteon) combination...
March 9, 2024: Advances in Therapy
#5
REVIEW
Christine Anh Burke, Victor W Nitti, Lynn Stothers
AIM: Causes of nocturia may extend beyond primary bladder pathology and it has been commonly associated as a side effect of sleep disorders. This has led to the study of melatonin and melatonin receptor agonists as a primary treatment for nocturia hypothesized to be secondary to sleep disorders. We aim to systematically review the efficacy and reported safety of melatonin and melatonin receptor agonists in the treatment of nocturia. METHODS: A search strategy of EMBASE and Pubmed/Medline databases was utilized to identify eligible studies...
March 8, 2024: Neurourology and Urodynamics
#6
JOURNAL ARTICLE
Ahmed Wahhab Mohammed Khafaji, Adeeb Ahmed Kadhim Al-Zubaidy, Iqbal Ghalib Farhood, Hayder Ridha Salman
Psoriasis is a long-lasting, immune-related inflammatory skin disease that affects 2-3% of the global population. It is distinguished by erythematous, silvery, and scaly patches. Ramelteon is a type of melatonin agonist that is used to treat insomnia. It has enhanced non-classical immunomodulatory and anti-inflammatory activities. The aim of the study is to assess the ameliorative effects of topical ramelteon on imiquimod (IMQ)-aggravated psoriasiform-like dermatosis in mice. The 32 albino mouse males were placed into six groups of eight animals, all of them...
March 6, 2024: Naunyn-Schmiedeberg's Archives of Pharmacology
#7
JOURNAL ARTICLE
Michele Fornaro, Claudio Caiazza, Flavia Rossano, Flavia Cilmi, Michele De Prisco, Eduard Vieta, Trevor Thompson, Marco Solmi, Andre Ferrer Carvalho, Felice Iasevoli, Andrea de Bartolomeis
Sleep medications often carry residual effects potentially affecting driving safety, warranting network meta-analysis (NMA). PubMed/EMBASE/TRID/Clinicaltrials.gov/WHO-ICTRP/WebOfScience were inquired for randomized controlled trials of hypnotic driving studies in persons with insomnia and healthy subjects up to 05/28/2023, considering the vehicle's standard deviation of lateral position - SDLP (Standardized Mean Difference/SMD) and driving impairment rates on the first morning (co-primary outcomes) and endpoint...
February 23, 2024: European Neuropsychopharmacology: the Journal of the European College of Neuropsychopharmacology
#8
REVIEW
M Elizabeth Wilcox, Lisa Burry, Marina Englesakis, Briar Coman, Marietou Daou, Frank Mp van Haren, E Wes Ely, Karen J Bosma, Melissa P Knauert
RATIONALE/OBJECTIVES: Despite plausible pathophysiological mechanisms, research is needed to confirm the relationship between sleep, circadian rhythm and delirium in patients admitted to the intensive care unit (ICU). The objective of this review is to summarise existing studies promoting, in whole or in part, the normalisation of sleep and circadian biology and their impact on the incidence, prevalence, duration and/or severity of delirium in ICU. METHODS: A sensitive search of electronic databases and conference proceedings was completed in March 2023...
February 13, 2024: Thorax
#9
JOURNAL ARTICLE
Zhenbo Yang, Yilin Xie, Mengyang Li, Wenxian Chen, Changsheng Zhong, Jin Ju, Qin Deng, Huifang Wang, Ting Cheng, Lei Zhang, Weijie Du, Haihai Liang
Reperfusion stands as a pivotal intervention for ischemic heart disease. However, the restoration of blood flow to ischemic tissue always lead to further damage, which is known as myocardial ischemia/reperfusion injury (MIRI). Ramelteon is an orally administered drug used to improve sleep quality, which is famous for its high bioadaptability and absence of notable addictive characteristics. However, the specific mechanism by which it improves MIRI is still unclear. Sirtuin-3 (Sirt3), primarily located in mitochondria, is crucial in mitigating many cardiac diseases, including MIRI...
February 6, 2024: Biomedicine & Pharmacotherapy
#10
Cheng-Hsien Huang
We recently observed a case involving a 12-year-old sighted girl who exhibited symptoms typical of non-24-hour sleep-wake disorder (N24SWD). This disorder, more commonly found in blind individuals, presents a unique challenge when diagnosed in those with vision. Several interventions can be attempted, ranging from behavioral adjustments to light therapy. Although melatonin has been noted for its effectiveness in realigning the patient's sleep-wake cycle, the use of ramelteon, a melatonin receptor agonist, has seldom been reported in managing N24SWD...
February 2, 2024: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
#11
JOURNAL ARTICLE
Ping Chen, Wei Liu, Yong Wei
BACKGROUND: Renal ischemia-reperfusion injury (IRI) is a common cause of acute kidney injury (AKI). This study explored the function and mechanisms of ramelteon on IRI-induced AKI. METHODS: Mice were randomly divided into five groups: Sham, IRI, IRI + ramelteon (0.3 mg/kg), IRI + ramelteon (1 mg/kg), and IRI + ramelteon (3 mg/kg). Mice were intraperitoneally treated with ramelteon for 7 days before IRI. IRI was accomplished by bilateral renal artery clamping for 30 minutes, after which the clamps were removed for blood reperfusion...
December 31, 2023: Translational Andrology and Urology
#12
JOURNAL ARTICLE
Giorgia D'Este, Federico Fabris, Marco Stazi, Chiara Baggio, Morena Simonato, Aram Megighian, Michela Rigoni, Samuele Negro, Cesare Montecucco
Snake envenoming is a major, but neglected, tropical disease. Among venomous snakes, those inducing neurotoxicity such as kraits (Bungarus genus) cause a potentially lethal peripheral neuroparalysis with respiratory deficit in a large number of people each year. In order to prevent the development of a deadly respiratory paralysis, hospitalization with pulmonary ventilation and use of antivenoms are the primary therapies currently employed. However, hospitals are frequently out of reach for envenomated patients and there is a general consensus that additional, non-expensive treatments, deliverable even long after the snake bite, are needed...
January 8, 2024: PLoS Neglected Tropical Diseases
#13
JOURNAL ARTICLE
Nobuyoshi Matsumoto
Sleep is fundamental for living animals. Although they are not conscious during sleep, their brains are continuously working. This neural activity during sleep can be reflected by neural oscillations closely related to cognitive function. While the relationship between neural activity in sleep and cognition has been extensively investigated, it is not fully understood how neural activity in sleep and relevant memory are modulated by specific receptors. In particular, I focused on melatonin receptors and their agonist, ramelteon...
2024: Yakugaku Zasshi: Journal of the Pharmaceutical Society of Japan
#14
Dayana Dominguez, Robert Rudock, Stuart Tomko, Sheel Pathak, Emmanuel Mignot, Amy Licis
Kleine-Levin syndrome (KLS) is a rare disorder characterized by episodic bouts of severe hypersomnia associated with cognitive and behavioral abnormalities, and normal alertness and functioning in between episodes. The pathophysiology is unclear but may involve neurotransmitter abnormalities, hypothalamic/thalamic dysfunction, viral/autoimmune etiology, or circadian abnormalities. No single treatment has been shown to be reliably efficacious; lithium has demonstrated the most consistent efficacy, although many do not respond and its use is limited by side effects...
December 29, 2023: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
#15
REVIEW
Alejandro Del Rio Verduzco, Ahva Salari, Parna Haghparast
INTRODUCTION: Chronic insomnia affects 5% to 10% of the US population, increasing the demand for treatment options and the corresponding research to prove their validity.1 This review compares recommendations from 3 clinical guidelines and summarizes hypnotic medications, including their newly reported side effects not mentioned in the guidelines. In addition, we aim to provide an overview of what pharmacotherapies are available for prescribers and patients. METHODS: A literature search was conducted for articles published prior to January 10, 2022, and case reports and clinical studies were retrieved from PubMed and Google Scholar...
October 2023: Mental Health Clinician
#16
JOURNAL ARTICLE
Masumi Tachibana, Nobuhisa Kanahara, Yasunori Oda, Tadashi Hasegawa, Atsushi Kimura, Masaomi Iyo
STUDY OBJECTIVES: Although novel hypnotics have recently emerged, there are currently no data comparing the clinical potency of benzodiazepine receptor agonists (BZRAs) and novel hypnotics, or the effectiveness of different methods of switching between them. This study examined how novel hypnotics might help reduce BZRA use in real-world practice. METHODS: 289 patients with psychiatric disorders who took BZRAs for over 1 year before switching to either of two dual-orexin receptor antagonists (DORAs) (suvorexant (SUV) or lemborexant (LEM)) or a melatonin receptor agonist (ramelteon (RMT)) were enrolled...
December 8, 2023: Journal of Clinical Sleep Medicine: JCSM: Official Publication of the American Academy of Sleep Medicine
#17
JOURNAL ARTICLE
Shoya Ikeuchi, Rei Tanaka, Teiichi Sugiura, Kaori Shinsato, Akane Wakabayashi, Junya Sato, Keiko Suzuki, Michihiro Shino
BACKGROUND: Suvorexant and ramelteon have been presented as useful for preventing postoperative delirium. Previous studies reported on the comparison with benzodiazepine hypnotics which have been known for the risk for inducing delirium, but the comparison with patients not taking any hypnotics has not been reported yet. Therefore, we assessed the incidence rates for postoperative delirium comparing cancer patients who received preoperative combined administration with suvorexant and ramelteon and those not taking any hypnotics...
December 1, 2023: Journal of Pharmaceutical Health Care and Sciences
#18
JOURNAL ARTICLE
Lei Zhang, Ting Cheng, Wenxian Chen, Changsheng Zhong, Mengyang Li, Yilin Xie, Qin Deng, Huifang Wang, Zhenbo Yang, Jin Ju, Haihai Liang
Pulmonary fibrosis (PF) is a devastating lung disease that leads to impaired lung function and ultimately death. Several studies have suggested that melatonin, a hormone involved in regulating sleep-wake cycles, may be effective in improving PF. Ramelteon, an FDA-approved melatonin receptor agonist, has shown promise in exerting an anti-PF effect similar to melatonin. However, further investigations are required for illuminating the extent on its therapeutic benefits and the underlying molecular mechanisms...
November 30, 2023: Naunyn-Schmiedeberg's Archives of Pharmacology
#19
REVIEW
Dieter Riemann, Colin A Espie, Ellemarije Altena, Erna Sif Arnardottir, Chiara Baglioni, Claudio L A Bassetti, Celyne Bastien, Natalija Berzina, Bjørn Bjorvatn, Dimitris Dikeos, Leja Dolenc Groselj, Jason G Ellis, Diego Garcia-Borreguero, Pierre A Geoffroy, Michaela Gjerstad, Marta Gonçalves, Elisabeth Hertenstein, Kerstin Hoedlmoser, Tuuliki Hion, Brigitte Holzinger, Karolina Janku, Markus Jansson-Fröjmark, Heli Järnefelt, Susanna Jernelöv, Poul Jørgen Jennum, Samson Khachatryan, Lukas Krone, Simon D Kyle, Jaap Lancee, Damien Leger, Adrian Lupusor, Daniel Ruivo Marques, Christoph Nissen, Laura Palagini, Tiina Paunio, Lampros Perogamvros, Dirk Pevernagie, Manuel Schabus, Tamar Shochat, Andras Szentkiralyi, Eus Van Someren, Annemieke van Straten, Adam Wichniak, Johan Verbraecken, Kai Spiegelhalder
Progress in the field of insomnia since 2017 necessitated this update of the European Insomnia Guideline. Recommendations for the diagnostic procedure for insomnia and its comorbidities are: clinical interview (encompassing sleep and medical history); the use of sleep questionnaires and diaries (and physical examination and additional measures where indicated) (A). Actigraphy is not recommended for the routine evaluation of insomnia (C), but may be useful for differential-diagnostic purposes (A). Polysomnography should be used to evaluate other sleep disorders if suspected (i...
December 2023: Journal of Sleep Research
#20
JOURNAL ARTICLE
Xinmu Zhang, Bin Peng, Shenqi Zhang, Jian Wang, Xiong Yuan, Sharon Peled, Wu Chen, Jinyin Ding, Wei Li, Andrew Zhang, Qiaofeng Wu, Irina G Stavrovskaya, Chengliang Luo, Bharati Sinha, Yanyang Tu, Xiaojing Yuan, Mingchang Li, Shuqing Liu, Jianfang Fu, Ali Aziz-Sultan, Bruce S Kristal, Gil Alterovitz, Rose Du, Shuanhu Zhou, Xin Wang
Stroke is the leading cause of death and disability worldwide. Novel and effective therapies for ischemic stroke are urgently needed. Here, we report that melatonin receptor 1A (MT1) agonist ramelteon is a neuroprotective drug candidate as demonstrated by comprehensive experimental models of ischemic stroke, including a middle cerebral artery occlusion (MCAO) mouse model of cerebral ischemia in vivo, organotypic hippocampal slice cultures ex vivo, and cultured neurons in vitro; the neuroprotective effects of ramelteon are diminished in MT1-knockout (KO) mice and MT1-KO cultured neurons...
November 20, 2023: Journal of Pineal Research
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
