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REVIEW
Mila Goldenberg, Leonid Kalichman
INTRODUCTION: Functional gastrointestinal disorders encompass a range of conditions resulting from complicated gut-brain interactions, which can negatively impact sufferers' lives. They are prevalent in clinical practice and the community, with a lifetime prevalence of almost 40 % worldwide. The challenge in diagnosing these disorders lies in the non-specificity of symptoms and the absence of reliable biomarkers. The existing literature suggests a multidisciplinary approach, including cognitive-behavioral therapy, dietary changes, psychotropic drug therapy, and improving gastrointestinal motility...
April 2024: Journal of Bodywork and Movement Therapies
#2
JOURNAL ARTICLE
Andrea Erriquez, Gianluca Campo, Vincenzo Guiducci, Gianni Casella, Mila Menozzi, Enrico Cerrato, Giorgio Sacchetta, Raul Moreno, Marco Arena, Ignacio Amat Santos, Jose Luis Diez Gil, Roberto Scarsini, Marco Ruozzi, Manfredi Arioti, Andrea Picchi, Marco Barbierato, Elisabetta Moscarella, Sergio Musto D'Amore, Valerio Lanzilotti, Caterina Cavazza, Marco Rezzaghi, Marta Cocco, Andrea Marrone, Filippo Maria Verardi, Javier Escaned, Emanuele Barbato, Iginio Colaiori, Nicola Pesenti, Greta Carrara, Simone Biscaglia
BACKGROUND: The role of quantitative flow ratio (QFR) in the treatment of nonculprit vessels of patients with myocardial infarction (MI) is a topic of ongoing discussion. OBJECTIVES: This study aimed to investigate the predictive capability of QFR for adverse events and its noninferiority compared to wire-based functional assessment in nonculprit vessels of MI patients. METHODS: The FIRE (Functional Assessment in Elderly MI Patients With Multivessel Disease) trial randomized 1,445 older MI patients to culprit-only (n = 725) or physiology-guided complete revascularization (n = 720)...
May 3, 2024: JACC. Cardiovascular Interventions
#3
RANDOMIZED CONTROLLED TRIAL
Zacarías Sánchez Milá, David Rodríguez Sanz, Ana Martín Nieto, Ana Jiménez Lobo, Manuel Ramos Hernández, Angélica Campón Chekroun, Raúl Frutos Llanes, José Manuel Barragán Casas, Jorge Velázquez Saornil
BACKGROUND: COVID-19 demonstrated the possibility of neurological complications such as loss of sense of smell and taste, together with respiratory problems. Respiratory training and rehabilitation of neurological sequelae are essential to improve respiratory function and thus quality of life, and the aim of this study is to evaluate the efficacy of a pulmonary and neurological rehabilitation program. OBJECTIVES: To apply a treatment to reduce dyspnea, increase exertional capacity, increase vital capacity and respiratory muscle strength, together with an increase in olfactory and gustatory sensitivity in post-SARS-CoV-2 patients...
2024: Chronic Respiratory Disease
#4
REVIEW
Kim R van Daalen, Cathryn Tonne, Jan C Semenza, Joacim Rocklöv, Anil Markandya, Niheer Dasandi, Slava Jankin, Hicham Achebak, Joan Ballester, Hannah Bechara, Thessa M Beck, Max W Callaghan, Bruno M Carvalho, Jonathan Chambers, Marta Cirah Pradas, Orin Courtenay, Shouro Dasgupta, Matthew J Eckelman, Zia Farooq, Peter Fransson, Elisa Gallo, Olga Gasparyan, Nube Gonzalez-Reviriego, Ian Hamilton, Risto Hänninen, Charles Hatfield, Kehan He, Aleksandra Kazmierczak, Vladimir Kendrovski, Harry Kennard, Gregor Kiesewetter, Rostislav Kouznetsov, Hedi Katre Kriit, Alba Llabrés-Brustenga, Simon J Lloyd, Martín Lotto Batista, Carla Maia, Jaime Martinez-Urtaza, Zhifu Mi, Carles Milà, Jan C Minx, Mark Nieuwenhuijsen, Julia Palamarchuk, Dafni Kalatzi Pantera, Marcos Quijal-Zamorano, Peter Rafaj, Elizabeth J Z Robinson, Nacho Sánchez-Valdivia, Daniel Scamman, Oliver Schmoll, Maquins Odhiambo Sewe, Jodi D Sherman, Pratik Singh, Elena Sirotkina, Henrik Sjödin, Mikhail Sofiev, Balakrishnan Solaraju-Murali, Marco Springmann, Marina Treskova, Joaquin Triñanes, Eline Vanuytrecht, Fabian Wagner, Maria Walawender, Laura Warnecke, Ran Zhang, Marina Romanello, Josep M Antò, Maria Nilsson, Rachel Lowe
No abstract text is available yet for this article.
May 10, 2024: Lancet. Public Health
#5
JOURNAL ARTICLE
Juan Camilo Grisales-Nieto, Sérgio Luiz Bessa Luz, Valdinete Alves do Nascimento, Felipe Gomes Naveca, Luz Mila Murcia-Montaño, Kelly Natalia Romero-Vesga, Olga Eshter Bellido-Cuellar, José Joaquín Carvajal-Cortés
OBJECTIVES: We report the first case of Oropouche fever detected in the border region of Colombia. METHODS: Using a multiplex real-time polymerase chain reaction (PCR), genetic sequencing and clinical characteristics during the dengue epidemic in 2019, a total of 175 samples were analysed, from cases notified to the system epidemiological surveillance such as dengue. FINDINGS: The Oropouche virus (OROV) isolate from Leticia belongs to lineage 2 according to both M and S genome segments maximum likelihood (ML) analysis, shares a common ancestor with samples obtained in Esmeraldas, Ecuador and Turbaco, Colombia...
2024: Memórias do Instituto Oswaldo Cruz
#6
Ana Rafaela Teixeira, Cintia Bittar, Gabriela S Silva Santos, Thiago Y Oliveira, Amy S Huang, Noemi Linden, Isabella A T M Ferreira, Tetyana Murdza, Frauke Muecksch, R Brad Jones, Marina Caskey, Mila Jankovic, Michel C Nussenzweig
HIV-1 anti-retroviral therapy is highly effective but fails to eliminate a reservoir of latent proviruses leading to a requirement for life-long treatment. How the site of integration of authentic intact latent proviruses might impact their own or neighboring gene expression or reservoir dynamics is poorly understood. Here we report on proviral and neighboring gene transcription at sites of intact latent HIV-1 integration in cultured T cells obtained directly from people living with HIV, as well as engineered primary T cells and cell lines...
April 29, 2024: bioRxiv
#7
JOURNAL ARTICLE
Kaili Zhong, Yaoyao Jiang, Haichao Hu, Bowen Yuan, Mila Wu, Aizhu Tu, Gecheng Xu, Linna Cai, Tingting Liu, Shiqi Gao, Linzhi Li, Qiansheng Liao, Lidan Guo, Ye Xia, Peng Liu, Ye Cheng, Lin Lin, Chuanxi Zhang, Jianping Chen, Jian Yang
No abstract text is available yet for this article.
April 27, 2024: Science Bulletin
#8
JOURNAL ARTICLE
Mila Gugnoni, Eugenia Lorenzini, Federica Torricelli, Benedetta Donati, Veronica Manicardi, Emanuele Vitale, Silvia Muccioli, Simonetta Piana, Filippo Lococo, Raffaella Zamponi, Paolo Gandellini, Alessia Ciarrocchi
Malignant pleural mesothelioma is a rare and lethal cancer caused by exposure to asbestos. The highly inflammatory environment caused by fibers accumulation forces cells to undergo profound adaptation to gain survival advantages. Prioritizing the synthesis of essential transcripts is an efficient mechanism coordinated by multiple molecules, including long non-coding RNAs. Enhancing the knowledge about these mechanisms is an essential weapon in combating mesothelioma. Linc00941 correlates to bad prognosis in various cancers, but it is reported to partake in distinct and apparently irreconcilable processes...
May 8, 2024: Cancer Letters
#9
JOURNAL ARTICLE
Anne C M Cuijpers, Tim Lubbers, Jaap J Dronkers, Aniek F J M Heldens, Siebrand B Zoethout, Duncan Leistra, Sander M J van Kuijk, Nico L U van Meeteren, Laurents P S Stassen, Bart C Bongers
INTRODUCTION: Preoperative aerobic fitness is associated with postoperative outcomes after elective colorectal cancer (CRC) surgery. This study aimed to develop and externally validate two clinical prediction models incorporating a practical test to assess preoperative aerobic fitness to distinguish between patients with and without an increased risk for 1) postoperative complications and 2) a prolonged time to in-hospital recovery of physical functioning after elective colorectal cancer (CRC) surgery...
April 11, 2024: European Journal of Surgical Oncology
#10
JOURNAL ARTICLE
Erin C Yang, Robby Divine, Marcos C Miranda, Andrew J Borst, Will Sheffler, Jason Z Zhang, Justin Decarreau, Amijai Saragovi, Mohamad Abedi, Nicolas Goldbach, Maggie Ahlrichs, Craig Dobbins, Alexis Hand, Suna Cheng, Mila Lamb, Paul M Levine, Sidney Chan, Rebecca Skotheim, Jorge Fallas, George Ueda, Joshua Lubner, Masaharu Somiya, Alena Khmelinskaia, Neil P King, David Baker
Programming protein nanomaterials to respond to changes in environmental conditions is a current challenge for protein design and is important for targeted delivery of biologics. Here we describe the design of octahedral non-porous nanoparticles with a targeting antibody on the two-fold symmetry axis, a designed trimer programmed to disassemble below a tunable pH transition point on the three-fold axis, and a designed tetramer on the four-fold symmetry axis. Designed non-covalent interfaces guide cooperative nanoparticle assembly from independently purified components, and a cryo-EM density map closely matches the computational design model...
May 9, 2024: Nature Structural & Molecular Biology
#11
JOURNAL ARTICLE
Andrea Erriquez, Gianluca Campo, Vincenzo Guiducci, Javier Escaned, Raul Moreno, Gianni Casella, Mila Menozzi, Enrico Cerrato, Giorgio Sacchetta, Alberto Menozzi, Ignacio Amat Santos, Enrique Gutiérrez Ibañes, Roberto Scarsini, Giuseppe Vadalà, Giuseppe Andò, José Luis Díez-Gil, Sergio Musto d'Amore, Alessandro Capecchi, Iginio Colaiori, Francesco Gallo, Rita Pavasini, Andrea Marrone, Graziella Pompei, Valerio Lanzilotti, Dariusz Dudek, Emanuele Barbato, Matteo Tebaldi, Simone Biscaglia
IMPORTANCE: Patients with high bleeding risk (HBR) have a poor prognosis, and it is not known if they may benefit from complete revascularization after myocardial infarction (MI). OBJECTIVE: To investigate the benefit of physiology-guided complete revascularization vs a culprit-only strategy in patients with HBR, MI, and multivessel disease. DESIGN, SETTING, AND PARTICIPANTS: This was a prespecified analysis of the Functional Assessment in Elderly MI Patients With Multivessel Disease (FIRE) randomized clinical trial data...
May 8, 2024: JAMA Cardiology
#12
REVIEW
Marcos Pereira, Italo Ricardo Santos Aleluia, Caroline Tianeze de Castro, Tarcio de Almeida Oliveira, Mila Silva Cunha, Laio Magno, Inês Dourado, Florisneide Barreto, Marcio Natividade, Seth Christopher Yaw Appiah, Erick Abade, Enny S Paixao, Maria Lidiany Tributino de Souza
This study aims to estimate the COVID-19 vaccine acceptance and hesitancy among people living with HIV (PLWHA). A search for observational studies was conducted in five databases and preprinted literature. Summary estimates were pooled using a random effects model and meta-regression. Of 150 identified studies, 31 were eligible (18,550 PLWHA). The weighted prevalence of COVID-19 vaccine hesitancy overall was 29.07% among PLWHA (95%CI = 24.33-34.32; I² = 98%,) and that of vaccine acceptance was 68...
May 7, 2024: AIDS and Behavior
#13
JOURNAL ARTICLE
Jan-Peter Grunz, Andreas Steven Kunz, Mila Marie Paul, Karsten Sebastian Luetkens, Henner Huflage, Nora Conrads, Süleyman Ergün, Thomas Weber, Magdalena Herbst, Sophia Herold, Thorsten Alexander Bley, Theresa Sophie Patzer
RATIONALE AND OBJECTIVES: This study investigates the performance of tomosynthesis in the presence of osteosynthetic implants, aiming to overcome superimposition-induced limitations in conventional radiograms. MATERIALS AND METHODS: After surgical fracture induction and subsequent osteosynthesis, 8 cadaveric fracture models (wrist, metacarpus, ankle, metatarsus) were scanned with the prototypical tomosynthesis mode of a multiuse x-ray system. Tomosynthesis protocols at 60, 80, and 116 kV (sweep angle 10°, 13 FPS) were compared with standard radiograms...
May 7, 2024: Investigative Radiology
#14
REVIEW
Giampiero I Baroncelli, Pasquale Comberiati, Tommaso Aversa, Federico Baronio, Alessandra Cassio, Mariangela Chiarito, Mirna Cosci O di Coscio, Luisa De Sanctis, Natascia Di Iorgi, Maria Felicia Faienza, Danilo Fintini, Roberto Franceschi, Mila Kalapurackal, Silvia Longhi, Michela Mariani, Marco Pitea, Andrea Secco, Daniele Tessaris, Francesco Vierucci, Malgorzata Wasniewska, Giovanna Weber, Stefano Mora
Rickets results from impaired mineralization of growing bone due to alterations in calcium and phosphate homeostasis. Clinical signs of rickets are related to the age of the patient, the duration of the disease, and the underlying disorder. The most common signs of rickets are swelling of the wrists, knees or ankles, bowing of the legs (knock-knees, outward bowing, or both) and inability to walk. However, clinical features alone cannot differentiate between the various forms of rickets. Rickets includes a heterogeneous group of acquired and inherited diseases...
2024: Frontiers in Endocrinology
#15
JOURNAL ARTICLE
Quentin Garrigues, Amélie Mugnier, Sylvie Chastant, Flavie Sicard, Jean-Charles Martin, Ljubica Svilar, Mathieu Castex, Manuel Guillermo Ramis-Vidal, Nicoletta Rovere, Laurine Michaud, Pauline David, Elodie Mansalier, Ana Rodiles, Hanna Mila, Emmanuelle Apper
Time around parturition is a stressful period for both bitches and their puppies. The use of probiotics has been proposed, e.g., in pigs, to improve health status of sows, their reproductive performances and in turn, the health and performance of their progeny. The objective of the present study was to evaluate the impact, on both dams and puppies, of a supplementation of bitches with the live yeast Saccharomyces cerevisiae var. boulardii CNCM I-1079 (SB-1079) during the second part of the gestation and the lactation period...
2024: Frontiers in Nutrition
#16
REVIEW
Effect of Alpha-1 Antitrypsin and Irisin on Post-Exercise Inflammatory Response: A Narrative Review.
Marta Pawłowska, Celestyna Mila-Kierzenkowska
Physical activity has a positive effect on human health and emotional well-being. However, in both amateur and professional athletes, training poses a risk of acute or chronic injury through repetitive overloading of bones, joints, and muscles. Inflammation can be an adverse effect of intense exercise caused by several factors including oxidative stress. The present narrative review summarizes current knowledge on inflammatory markers induced by physical exercise. Post-exercise recovery may reduce inflammatory responses and is key to effective training and adaptation of muscle tissues to sustained physical exertion...
April 2024: Iranian Journal of Medical Sciences
#17
JOURNAL ARTICLE
Jayshree Ap Segar, Teo Rong Xuan, Alahakoon Mudiyanselage Gayali Nuwanya Alahakoon, Harwinthra Al Ravi, Soe Moe, Murali Uthamalingam, Mila Nu Nu Htay
AIM: Breast cancer is commonest cancer among Malaysian women and screening is essential for the early detection. Therefore our study aimed at measuring the levels of knowledge, attitude and perception towards personalized risk stratified breast cancer screening in Malaysia. METHODS: A cross-sectional study was carried out in Malaysia to assess the knowledge, perception and attitudes of the women in Malaysia. The study was conducted using an online questionnaire, and samples were obtained using convenience sampling...
April 1, 2024: Asian Pacific Journal of Cancer Prevention: APJCP
#18
REVIEW
Jasminka Talapko, Domagoj Talapko, Darko Katalinić, Ivan Kotris, Ivan Erić, Dino Belić, Mila Vasilj Mihaljević, Ana Vasilj, Suzana Erić, Josipa Flam, Sanja Bekić, Suzana Matić, Ivana Škrlec
Radioactivity is a process in which the nuclei of unstable atoms spontaneously decay, producing other nuclei and releasing energy in the form of ionizing radiation in the form of alpha (α) and beta (β) particles as well as the emission of gamma (γ) electromagnetic waves. People may be exposed to radiation in various forms, as casualties of nuclear accidents, workers in power plants, or while working and using different radiation sources in medicine and health care. Acute radiation syndrome (ARS) occurs in subjects exposed to a very high dose of radiation in a very short period of time...
April 18, 2024: Medicina
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JOURNAL ARTICLE
Ligia Petrica, Florica Gadalean, Danina Mirela Muntean, Dragos Catalin Jianu, Daliborca Vlad, Victor Dumitrascu, Flaviu Bob, Oana Milas, Anca Suteanu-Simulescu, Mihaela Glavan, Sorin Ursoniu, Lavinia Balint, Maria Mogos-Stefan, Silvia Ienciu, Octavian Marius Cretu, Roxana Popescu, Cristina Gluhovschi, Lavinia Iancu, Adrian Vlad
Cerebrovascular disease accounts for major neurologic disabilities in patients with type 2 diabetes mellitus (DM). A potential association of mitochondrial DNA ( mtDNA ) and inflammation with cerebral vessel remodeling in patients with type 2 DM was evaluated. A cohort of 150 patients and 30 healthy controls were assessed concerning urinary albumin/creatinine ratio (UACR), synaptopodin, podocalyxin, kidney injury molecule-1 (KIM-1), N-acetyl-β-(D)-glucosaminidase (NAG), interleukins IL-17A, IL-18, IL-10, tumor necrosis factor-alpha (TNFα), intercellular adhesion molecule-1 (ICAM-1)...
April 19, 2024: Biomolecules
#20
JOURNAL ARTICLE
Woojin Choi, Milae Lee, Hyungseok Yong, Deokjae Heo, Taesuk Jun, Hanwook Ryu, Ji-Yeong Kim, Dingyun Cui, Du Yeol Ryu, Sang-Young Lee, Sung-Hwan Choi, Byeong-Su Kim, Jiyu Kim, Se Yong Jung, Sangmin Lee, Jinkee Hong
The Liesegang pattern is a beautiful natural anisotropic patterning phenomenon observed in rocks and sandstones. This study reveals that the Liesegang pattern can induce nonlinear elasticity. Here, a Liesegang-patterned complex with biomineral-hydrogel repetitive layers is prepared. This Liesegang-patterned complex is obtained only when the biomineralization is performed under the supersaturated conditions. The Liesegang-patterned complex features a nonlinear elastic response, whereas a complex with a single biomineral shell shows a linear behavior, thus demonstrating that the Liesegang pattern is essential in achieving nonlinear elasticity...
April 26, 2024: Science Advances
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