Gustavo Simão Moraes, Thaís Albach, Carolina Yoshi Campos Sugio, Victoria Schlumberger Cachoeira, Falyne Kiratcz, Nathaly Mayer Tozzeto, Thaynara Aparecida Alves Pedroso, Eduardo Bauml Campagnoli, Marcela Claudino, Fabio André Dos Santos, Karin Hermana Neppelenbroek, Vanessa Migliorini Urban
AIM: This study investigated the effectiveness of a drug-modified tissue conditioner in an animal model of denture stomatitis. METHODS AND RESULTS: Wistar rats wore a Candida albicans-contaminated palatal device for four days. Next, nystatin (Nys) or chlorhexidine (Chx) were added to a tissue conditioner in their raw or β-cyclodextrin-complexed (βCD) forms at their minimum inhibitory concentrations. As controls, one group was not subjected to any procedure (NC), one group used sterile devices (SD), one group had denture stomatitis but was not treated (DS), and another had the devices relined with the tissue conditioner without the addition of any drug (Soft)...
May 14, 2024: Journal of Applied Microbiology