Chee Kin Then, Salome Paillas, Aliu Moomin, Mariya D Misheva, Rachel A Moir, Susan M Hay, David Bremner, Kristine S Roberts Nee Nellany, Ellen E Smith, Zeynab Heidari, Daniel Sescu, Xuedan Wang, Alejandro Suárez-Bonnet, Nadine Hay, Sarah L Murdoch, Ryoichi Saito, Elaina S R Collie-Duguid, Shirley Richardson, Simon L Priestnall, Joan M Wilson, Mahalakshmi Gurumurthy, Justine S Royle, Leslie M Samuel, George Ramsay, Katherine A Vallis, Kevin R Foster, James S O McCullagh, Anne E Kiltie
BACKGROUND: Non-toxic approaches to enhance radiotherapy outcomes are beneficial, particularly in ageing populations. Based on preclinical findings showing that high-fibre diets sensitised bladder tumours to irradiation by modifying the gut microbiota, along with clinical evidence of prebiotics enhancing anti-cancer immunity, we hypothesised that dietary fibre and its gut microbiota modification can radiosensitise tumours via secretion of metabolites and/or immunomodulation. We investigated the efficacy of high-fibre diets combined with irradiation in immunoproficient C57BL/6 mice bearing bladder cancer flank allografts...
May 14, 2024: Microbiome