Jakub Kopal, Kuldeep Kumar, Kimia Shafighi, Karin Saltoun, Claudia Modenato, Clara A Moreau, Guillaume Huguet, Martineau Jean-Louis, Charles-Olivier Martin, Zohra Saci, Nadine Younis, Elise Douard, Khadije Jizi, Alexis Beauchamp-Chatel, Leila Kushan, Ana I Silva, Marianne B M van den Bree, David E J Linden, Michael J Owen, Jeremy Hall, Sarah Lippé, Bogdan Draganski, Ida E Sønderby, Ole A Andreassen, David C Glahn, Paul M Thompson, Carrie E Bearden, Robert Zatorre, Sébastien Jacquemont, Danilo Bzdok
Asymmetry between the left and right hemisphere is a key feature of brain organization. Hemispheric functional specialization underlies some of the most advanced human-defining cognitive operations, such as articulated language, perspective taking, or rapid detection of facial cues. Yet, genetic investigations into brain asymmetry have mostly relied on common variants, which typically exert small effects on brain-related phenotypes. Here, we leverage rare genomic deletions and duplications to study how genetic alterations reverberate in human brain and behavior...
March 26, 2024: Nature Communications