Hongyu Tang, Zhijie Wang, Haoyang Hao, Weixian Luo, Jingru Yang, Mengyao Li, Mingxin Yang, Ziteng Chen, Ruyu Yan, Hao Li, Fan Hu, Haojun Liang, Qiuyang Liu, Linwen Lv, Junhui Zhang, Wenxi Su, Ranran Chen, Kui Chen, Ya-Nan Chang, Meng Wang, Lingna Zheng, Xuesong Feng, Juan Li, Gengmei Xing
Nanocarriers have been researched comprehensively for the development of novel boron-containing agents in boron neutron capture therapy (BNCT). We designed and synthesized a multifunctional mesoporous silica nanoparticle (MSN)-based boron-containing agent. The latter was coated with a lipid bilayer (LB) and decorated with SP94 peptide (SFSIIHTPILPL) on the surface as SP94-LB@BA-MSN. The latter incorporated boric acid (BA) into hydrophobic mesopores, coated with an LB, and modified with SP94 peptide on the LB...
April 30, 2024: ACS Applied Materials & Interfaces