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JOURNAL ARTICLE
Taiki Kawamura, Kazuyoshi Yoshimi, Kenichiro Hashimoto, Akito Kobayashi, Takahiro Misawa
The study of the magnetic order has recently been invigorated by the discovery of exotic collinear antiferromagnets with time-reversal symmetry breaking. Examples include altermagnets and compensated ferrimagnets, which show spin splittings of the electronic band structures even at zero net magnetization, leading to several unique transport phenomena, notably spin-current generation. Altermagnets demonstrate anisotropic spin splitting, such as d-wave, in momentum space, whereas compensated ferrimagnets exhibit isotropic spin splitting...
April 12, 2024: Physical Review Letters
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JOURNAL ARTICLE
R Peraita-Adrados, N Bravo-Quelle
INTRODUCTION: We present a narcolepsy type 1 patient that develop an autoimmune encephalitis post vaccine and/or a SARS-CoV-2 infection. CASE REPORT: At 23 years old, the patient was referred to the emergency room with difficult speaking, headache and tremor followed by changes in behavior, autonomic dysfunction, right focal motor seizure and lethargy. He has received seven weeks before mRNA-1273 (Moderna) vaccine followed by a SARS-CoV-2 infection four weeks after vaccination (positive antigen test)...
May 1, 2024: Revista de Neurologia
#3
JOURNAL ARTICLE
Yuna Miura, Masatsugu Hashimoto, Yasutaka Nakamura, Noboru Ishikawa
Short tandem repeat (STR) typing is widely used not only for blood relationship identification but also for the personal identification of unidentified bodies. However, DNA is susceptible to the effects of environmental factors, consequently leading to reduced DNA yields. Therefore, to maximize the DNA yield required for identification, teeth are generally completely pulverized during DNA extraction. However, this renders subsequent testing after DNA profiling impossible. In this study, we investigated the utility of DNA profiling using only the cementum from teeth that had been left outdoors for long postmortem intervals...
March 2024: Curēus
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JOURNAL ARTICLE
Kazuhiro Takahashi, Masahiko Gosho, Yoshihiro Miyazaki, Hiromitsu Nakahashi, Osamu Shimomura, Kinji Furuya, Manami Doi, Yohei Owada, Koichi Ogawa, Yusuke Ohara, Yoshimasa Akashi, Tsuyoshi Enomoto, Shinji Hashimoto, Tatsuya Oda
BACKGROUND: The success of liver resection relies on the ability of the remnant liver to regenerate. Most of the knowledge regarding the pathophysiological basis of liver regeneration comes from rodent studies, and data on humans are scarce. Additionally, there is limited knowledge about the preoperative factors that influence postoperative regeneration. AIM: To quantify postoperative remnant liver volume by the latest volumetric software and investigate perioperative factors that affect posthepatectomy liver regeneration...
April 14, 2024: World Journal of Gastroenterology: WJG
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JOURNAL ARTICLE
Yuta Inagaki, Kohki Hashimoto, Shinnosuke Wakamori, Ryo Katsuta, Arata Yajima, Daisuke Kaida, Ken Ishigami
CGK733 was reported as a compound that inhibited ATM/ATR kinase activities and blocked their checkpoint signaling pathways with great selectivity. However, this paper was subsequently retracted, and the truth about the activity of CGK733 remains unclear. We synthesized various analogs of CGK733 with a modification of the carboxylic acid moiety and/or the aniline derivative moiety to accumulate knowledge of the structure-activity relationship of this compound. Growth inhibitory activity of CGK733 and novel 35 analogs against HeLa S3 cells was evaluated, and the structure-activity relationship revealed that analogs with 2-naphthyl or 4-fluorophenyl group instead of the benzhydryl group have activity comparable to CGK733 and that the 3-nitro group on the aniline moiety significantly affects the activity...
April 27, 2024: Bioscience, Biotechnology, and Biochemistry
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JOURNAL ARTICLE
Toru Aoyama, Itaru Hashimoto, Yukio Maezawa, Kentaro Hara, Ayako Tamagawa, Haruhiko Cho, Junya Morita, Mie Tanabe, Masakatsu Numata, Shinnosuke Kawahara, Takashi Oshima, Aya Saito, Norio Yukawa
BACKGROUND/AIM: The prognostic immune and nutritional index (PINI) was developed and reported as a promising prognostic factor. This study aimed to clarify the clinical impact of the PINI in gastric cancer (GC) patients who received curative treatment. PATIENTS AND METHODS: Patients who underwent curative resection for GC at Yokohama City University between 2005 and 2020 were selected based on their medical records. The PINI was calculated by dividing the serum albumin concentration (g/dl) by the serum monocyte concentration...
May 2024: Anticancer Research
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JOURNAL ARTICLE
Toru Aoyama, Itaru Hashimoto, Yukio Maezawa, Kentaro Hara, Aya Kato, Keisuke Kazama, Ayako Tamagawa, Haruhiko Cho, Masato Nakazono, Masakatsu Numata, Shinnosuke Kawahara, Takashi Oshima, Aya Saito, Norio Yukawa
BACKGROUND/AIM: Recently, the prognostic immune and nutritional index (PINI) was developed and reported to be a promising nutritional and inflammatory prognostic marker. The aim of the present study was to clarify the clinical impact of the PINI for esophageal cancer patients who received curative treatment. PATIENTS AND METHODS: We conducted a retrospective review of medical records and collected data on consecutive esophageal cancer patients who underwent curative resection at Yokohama City University between 2005 and 2020...
May 2024: Anticancer Research
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JOURNAL ARTICLE
Letyfee Steinert, Michael Fuchs, Anna M Sigmund, Dario Didona, Christoph Hudemann, Christian Möbs, Michael Hertl, Takashi Hashimoto, Jens Waschke, Franziska Vielmuth
During differentiation, keratinocytes acquire a strong, hyper-adhesive state, where desmosomal cadherins interact Ca2+ -independently. Previous data indicate that hyper-adhesion protects keratinocytes from pemphigus vulgaris autoantibody (PV-IgG)-induced loss of intercellular adhesion although the underlying mechanism remains to be elucidated. Thus, we here investigated the effect of hyper-adhesion on PV-IgG-induced direct inhibition of desmoglein (Dsg) 3 interactions by atomic force microscopy. Hyper-adhesion abolished loss of intercellular adhesion and corresponding morphological changes of all pathogenic antibodies used...
April 25, 2024: Journal of Investigative Dermatology
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JOURNAL ARTICLE
Masaki Watanabe, Yuki Ishii, Kazuki Hashimoto, Hayato R Takimoto, Nobuya Sasaki
The Adriamycin (ADR) nephropathy model, which induces podocyte injury, is limited to certain mouse strains due to genetic susceptibilities, such as the PrkdcR2140C polymorphism. The FVB/N strain without the R2140C mutation resists ADR nephropathy. Meanwhile, a detailed analysis of the progression of ADR nephropathy in the FVB/N strain has yet to be conducted. Our research aimed to create a novel mouse model, the FVB- PrkdcR2140C , by introducing PrkdcR2140C into the FVB/NJcl (FVB) strain. Our study showed that FVB- PrkdcR2140C mice developed severe renal damage when exposed to ADR, as evidenced by significant albuminuria and tubular injury, exceeding the levels observed in C57BL/6J (B6)- PrkdcR2140C ...
April 4, 2024: Genes
#10
Motohiro Kimata, Kenichi Hashimoto, Naomi Harada, Yusuke Kawamura, Yoshifumi Kimizuka, Yuji Fujikura, Mayuko Kaneko, Nobuaki Kiriu, Yasumasa Sekine, Natsumi Iwabuchi, Tetsuro Kiyozumi, Akihiko Kawana, Susumu Matsukuma, Yuji Tanaka
Coronavirus disease 2019 (COVID-19) has affected medical practice. More than 7,000,000 patients died worldwide after being infected with COVID-19; however, no specific laboratory markers have yet been established to predict death related to this disease. In contrast, electrocardiographic changes due to COVID-19 include QT prolongation and ST-T changes; however, there have not been studies on the ambulatory electrocardiographic markers of COVID-19. We encountered three patients diagnosed as having COVID-19 who did not have a prior history of significant structural heart diseases...
April 19, 2024: Medicina
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JOURNAL ARTICLE
Alin-Dan Chiorean, Gheorghe Zsolt Nicula, Ștefana Bâlici, Mihaela Laura Vică, Luminita-Ioana Iancu Loga, Lucia Dican, Horea Vladi Matei
Autoimmune thyroid diseases (AITD), particularly Hashimoto's thyroiditis (HT) and Basedow-Graves disease (BGD) are diseases of global public health concern, characterized by autoimmune attacks on the thyroid gland, leading to hypothyroidism in HT and hyperthyroidism in BGD. We conducted a study between 2019 and 2021 in northwestern Transylvania (Romania) on patients with HT and with BGD compared to the control group. The aim of the study was to investigate the correlations of HLA class II alleles with AITD by identifying potential genetic susceptibility factors such as HLA-DRB1 and HLA-DQB1 genes in patients diagnosed with HT and BGD...
March 27, 2024: Life
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JOURNAL ARTICLE
Aasa Shimizu, Kenjiro Sawada, Masaki Kobayashi, Yukako Oi, Tadashi Oride, Yasuto Kinose, Michiko Kodama, Kae Hashimoto, Tadashi Kimura
RNA interference is a powerful gene-silencing tool with potential clinical applications. However, its therapeutic use is challenging because suitable carriers are unavailable. Exosomes are stable small endogenous vesicles that can transport functional molecules to target cells, making them ideal small interfering RNA (siRNA) carriers. Herein, we elucidated the therapeutic potential of patient-derived exosomes as an siRNA carrier for ovarian cancer (OC) treatment. The exosomes were extracted from the culture medium of primary fibroblasts collected from the omentum of patients with OC during surgery...
April 12, 2024: Cancers
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REVIEW
Sami Fares, Chase J Wehrle, Hanna Hong, Keyue Sun, Chunbao Jiao, Mingyi Zhang, Abby Gross, Erlind Allkushi, Melis Uysal, Suneel Kamath, Wen Wee Ma, Jamak Modaresi Esfeh, Maureen Whitsett Linganna, Mazhar Khalil, Alejandro Pita, Jaekeun Kim, R Matthew Walsh, Charles Miller, Koji Hashimoto, Andrea Schlegel, David Choon Hyuck Kwon, Federico Aucejo
Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related death and the sixth most diagnosed malignancy worldwide. Serum alpha-fetoprotein (AFP) is the traditional, ubiquitous biomarker for HCC. However, there has been an increasing call for the use of multiple biomarkers to optimize care for these patients. AFP, AFP-L3, and prothrombin induced by vitamin K absence II (DCP) have described clinical utility for HCC, but unfortunately, they also have well established and significant limitations...
April 10, 2024: Cancers
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JOURNAL ARTICLE
Beata Sawicka, Anetta Sulewska, Agnieszka Kulczyńska-Przybik, Filip Bossowski, Maciej Dulewicz, Hanna Borysewicz-Sańczyk, Barbara Mroczko, Jacek Nikliński, Artur Bossowski
BACKGROUND: Many epigenetic factors, including microRNAs, are involved in the process of changing gene expressions. Small non-coding RNA molecules, called miRNAs, are responsible for regulating gene translation by silencing or degrading target mRNAs. It is acknowledged that for many diseases, they may be novel diagnostic and prognostic biomarkers. Patients with autoimmune thyroid diseases are more likely to develop nodules in the thyroid tissue, and Hashimoto's thyroiditis and Graves' disease predispose patients to thyroid cancer...
March 25, 2024: Biomedicines
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REVIEW
Ryosuke Kakinoki, Yukiko Hara, Koichi Yoshimoto, Yukitoshi Kaizawa, Kazuhiko Hashimoto, Hiroki Tanaka, Takaya Kobayashi, Kazuhiro Ohtani, Takashi Noguchi, Ryosuke Ikeguchi, Masao Akagi, Koji Goto
There are many commercially available artificial nerve conduits, used mostly to repair short gaps in sensory nerves. The stages of nerve regeneration in a nerve conduit are fibrin matrix formation between the nerve stumps joined to the conduit, capillary extension and Schwann cell migration from both nerve stumps, and, finally, axon extension from the proximal nerve stump. Artificial nerves connecting transected nerve stumps with a long interstump gap should be biodegradable, soft and pliable; have the ability to maintain an intrachamber fibrin matrix structure that allows capillary invasion of the tubular lumen, inhibition of scar tissue invasion and leakage of intratubular neurochemical factors from the chamber; and be able to accommodate cells that produce neurochemical factors that promote nerve regeneration...
April 22, 2024: Bioengineering
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JOURNAL ARTICLE
Maya Toyama, Michihiro Satoh, Shingo Nakayama, Hideaki Hashimoto, Tomoko Muroya, Takahisa Murakami, Takuo Hirose, Taku Obara, Naoki Nakaya, Takefumi Mori, Takayoshi Ohkubo, Yutaka Imai, Atsushi Hozawa, Hirohito Metoki
This study aimed to assess the combined effects of blood pressure (BP) and glucose status on chronic kidney disease (CKD) incidence in young and middle-aged adults. We examined data from 1,297,341 Japanese individuals aged <60 years (60.1% men; mean age 41.4 ± 9.3 years) with no history of CKD at baseline. The interval-censored Cox proportional hazards model with covariates was used. During a median follow-up period of 2.1 years, new onset CKD (estimated glomerular filtration rate <60 ml/min/1...
April 26, 2024: Hypertension Research: Official Journal of the Japanese Society of Hypertension
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JOURNAL ARTICLE
Yihang Li, Xiaokai Lu, Weihan Cao, Nianqiu Liu, Xin Jin, Yuting Li, Shiying Tang, Ling Tao, Qian Zhu, Hongmin Liang
(1) BACKGROUND: Hashimoto's thyroiditis (HT) can cause angiogenesis in the thyroid gland. However, the molecular mechanism of endothelial cells and angiogenesis related genes (ARGs) has not been extensively studied in HT. (2) METHODS: The HRA001684, GSE29315 and GSE163203 datasets were included in this study. Using single-cell analysis, weighted gene co-expression network analysis (WGCNA), functional enrichment analysis, machine learning algorithms and expression analysis for exploration. And receiver operator characteristic (ROC) curves was draw...
April 24, 2024: Archives of Biochemistry and Biophysics
#18
JOURNAL ARTICLE
Hirofumi Kamata, Kazufumi Takamatsu, Koichi Fukunaga, Shotaro Chubachi, Kensuke Nakagawara, Ho Namkoong, Hideki Terai, Katsushi Tanaka, Susumu Sato, Eri Hagiwara, Reoto Takei, Yasuhiro Kondoh, Takahiro Takazono, Midori Hashimoto, Sadatomo Tasaka, Takashi Ohrui, Yoshinori Tanino, Masamichi Mineshita, Yuko Komase, Kazuhito Miyazaki, Masanori Nishikawa, Akira Ando, Hideo Kita, Eiki Ichihara, Shinichiro Ohshimo, Yoriyuki Murata, Masayuki Ishida, Seiichi Kobayashi, Takahiro Uchida, Hiroki Tateno, Jun Ikari, Takeshi Terashima, Yutaka Kozu, Tomoya Tateishi, Masaharu Shinkai, Hironori Sagara, Yasuo To, Yoko Ito, Masaki Yamamoto, Yoshihiro Yamamoto, Toshiyuki Kita, Yutaka Ito, Keisuke Tomii, Yukio Fujita, Yoshihiro Funaki, Kazuhiro Yatera, Mari Yamasue, Kosaku Komiya, Satoko Kozawa, Hideaki Manabe, Hironao Hozumi, Tomoya Horiguchi, Takamasa Kitajima, Yasushi Nakano, Tetsutaro Nagaoka, Masayuki Hojo, Akinori Ebihara, Masayoshi Kobayashi, Koji Takayama, Torahiko Jinta, Toyomitsu Sawai, Yuichi Fukuda, Takeshi Kaneko, Kazuo Chin, Takashi Ogura, Hiroshi Mukae, Makoto Ishii, Akihito Yokoyama
BACKGROUND: No comprehensive analysis of the pulmonary sequelae of coronavirus disease 2019 (COVID-19) in Japan based on respiratory function tests and chest computed tomography (CT) has been reported. We evaluated post-COVID-19 conditions, especially focusing on pulmonary sequelae assessed by pulmonary function tests and chest CT. METHODS: For this prospective cohort study, we enrolled 1069 patients who presented pneumonia at the time of admission in 55 hospitals from February 2020 to September 2021...
April 25, 2024: Respiratory Investigation
#19
JOURNAL ARTICLE
Qing Tao, Yu Chen, Qiao Liang, Jianfeng Shi, Zhiguo Wang, Haiyan Min, Qian Gao, Xiaoming Yao, Lei Wang
Hashimoto's thyroiditis (HT) is the most common organ-specific autoimmune disease, predominantly affecting women. Although the pathogenesis of HT is incompletely understood, some studies have found that macrophage polarization plays a role. Puerarin is a soy isoflavone compound that has anti-inflammatory and immunomodulatory effects and regulates macrophage immune activity. This study aimed to verify the therapeutic effect of puerarin on HT and explored its regulatory effect on macrophage polarization imbalance in HT...
April 26, 2024: Journal of Immunology
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JOURNAL ARTICLE
Seiji Ogo, Takeshi Yatabe, Keishi Miyazawa, Yunosuke Hashimoto, Chiaki Takahashi, Hidetaka Nakai, Yoshihito Shiota
Have you ever imagined reactions of alkenes with hydrogen that result in anything other than hydrogenation or hydrogenative C-C coupling? We have long sought to develop not only hydrogenation catalysts that activate H2 as hydride ions but also electron transfer catalysts that activate H2 as a direct electron donor. Here, we report the reductive cyclopropanation of alkenes using an iridium electron storage catalyst with H2 as the electron source without releasing metal waste from the reductant. We discuss the catalytic mechanism with selectivity to give the trans -isomer...
April 22, 2024: JACS Au
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