Hrishikesh Suresh, Benjamin R Morgan, Karim Mithani, Nebras M Warsi, Han Yan, Jürgen Germann, Alexandre Boutet, Aaron Loh, Flavia Venetucci Gouveia, Julia Young, Jennifer Quon, Felipe Morgado, Jason Lerch, Andres M Lozano, Bassam Al-Fatly, Andrea Kühn, Suzanne Laughlin, Michael C Dewan, Donald Mabbot, Carolina Gorodetsky, Ute Bartels, Annie Huang, Uri Tabori, James T Rutka, James M Drake, Abhaya V Kulkarni, Peter Dirks, Michael D Taylor, Vijay Ramaswamy, George M Ibrahim
BACKGROUND: Cerebellar mutism syndrome (CMS) is a common and debilitating complication of posterior fossa tumour surgery in children. Affected children exhibit communication and social impairments that overlap phenomenologically with subsets of deficits exhibited by children with Autism spectrum disorder (ASD). Although both CMS and ASD are thought to involve disrupted cerebro-cerebellar circuitry, they are considered independent conditions due to an incomplete understanding of their shared neural substrates...
December 11, 2023: Neuro-oncology