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https://read.qxmd.com/read/32533834/endothelium-restricted-endothelin-1-overexpression-in-type-1-diabetes-worsens-atherosclerosis-and-immune-cell-infiltration-via-nox1
#41
Sofiane Ouerd, Noureddine Idris-Khodja, Michelle Trindade, Nathanne S Ferreira, Olga Berillo, Suellen C Coelho, Mario F Neves, Karin A Jandeleit-Dahm, Pierre Paradis, Ernesto L Schiffrin
AIMS: NADPH oxidase (NOX) 1 but not NOX4-dependent oxidative stress plays a role in diabetic vascular disease, including atherosclerosis. Endothelin (ET)-1 has been implicated in diabetes-induced vascular complications. We showed that crossing mice overexpressing human ET-1 selectively in endothelium (eET-1) with apolipoprotein E knockout (Apoe-/-) mice enhanced high-fat diet-induced atherosclerosis in part by increasing oxidative stress. We tested the hypothesis that ET-1 overexpression in the endothelium would worsen atherosclerosis in type-1 diabetes through a mechanism involving NOX1 but not NOX4...
June 13, 2020: Cardiovascular Research
https://read.qxmd.com/read/32528072/topical-application-of-endothelin-receptor-a-antagonist-attenuates-imiquimod-induced-psoriasiform-skin-inflammation
#42
Takeshi Nakahara, Makiko Kido-Nakahara, Dugarmaa Ulzii, Sho Miake, Kei Fujishima, Sawako Sakai, Takahito Chiba, Gaku Tsuji, Masutaka Furue
Endothelin-1 (ET-1) is well known as the most potent vasoconstrictor, and can evoke histamine-independent pruritus. Recently, its involvement in cutaneous inflammation has begun to draw attention. The upregulation of ET-1 expression in the epidermis of human psoriasis patients has been reported. It was also demonstrated that ET-1 can stimulate dendritic cells to induce Th17/1 immune responses. However, the role of the interaction between ET-1 and ET-1 receptors in the pathogenesis of psoriasis remains elusive...
June 11, 2020: Scientific Reports
https://read.qxmd.com/read/32523314/sleeve-gastrectomy-ameliorates-endothelial-function-and-prevents-lung-cancer-by-normalizing-endothelin-1-axis-in-obese-and-diabetic-rats
#43
Rexiati Ruze, Ya-Cheng Xiong, Jian-Wen Li, Ming-Wei Zhong, Qian Xu, Zhi-Bo Yan, Jian-Kang Zhu, Yu-Gang Cheng, San-Yuan Hu, Guang-Yong Zhang
BACKGROUND: Previous evidence has implied that obesity is an independent risk factor for developing cancer. Being closely related to obesity, type 2 diabetes mellitus provides a suitable environment for the formation and metastasis of tumors through multiple pathways. Although bariatric surgeries are effective in preventing and lowering the risk of various types of cancer, the underlying mechanisms of this effect are not clearly elucidated. AIM: To uncover the role and effect of sleeve gastrectomy (SG) in preventing lung cancer in obese and diabetic rats...
May 28, 2020: World Journal of Gastroenterology: WJG
https://read.qxmd.com/read/32521539/pulmonary-hypertension-in-bronchopulmonary-dysplasia
#44
REVIEW
Georg Hansmann, Hannes Sallmon, Charles C Roehr, Stella Kourembanas, Eric D Austin, Martin Koestenberger
Bronchopulmonary dysplasia (BPD) is a major complication in prematurely born infants. Pulmonary hypertension (PH) associated with BPD (BPD-PH) is characterized by alveolar diffusion impairment, abnormal vascular remodeling, and rarefication of pulmonary vessels (vascular growth arrest), which lead to increased pulmonary vascular resistance and right heart failure. About 25% of infants with moderate to severe BPD develop BPD-PH that is associated with high morbidity and mortality. The recent evolution of broader PH-targeted pharmacotherapy in adults has opened up new treatment options for infants with BPD-PH...
June 10, 2020: Pediatric Research
https://read.qxmd.com/read/32518777/ligliptin-for-treatment-of-type-2-diabetes-mellitus-with-early-renal-injury-efficacy-and-impact-on-endogenous-hydrogen-sulfide-and-endothelial-function
#45
Jian Zhang, Yong-Li Du, Hui Zhang, Hong Sui, Wei-Kai Hou
BACKGROUND: Diabetes is a clinically common chronic disease, and its incidence has been increasing in recent years. Diabetes is believed to accelerate the process of atherosclerosis in patients, and abnormal endothelial function is an important factor leading to diabetic kidney damage. AIM: To investigate the efficacy of ligliptin in the treatment of type 2 diabetes mellitus (T2DM) with early renal injury and its effect on serum endogenous hydrogen sulfide (H2 S), endothelial cell particles, and endothelial function...
May 26, 2020: World Journal of Clinical Cases
https://read.qxmd.com/read/32517881/correlation-between-serum-levels-of-endothelin-1-and-disease-severity-in-patients-with-neuromyelitis-optica-spectrum-disorders
#46
Ming Yi, Ming-Qi Liu, Li-Sha Chou, Shu-Min Jiang, Lin-Jie Zhang, Chen-Na Huang, Nan Wang, Qiu-Xia Zhang, Li Yang
AIMS: Neuromyelitis optica spectrum disorders (NMOSD) are aquaporin-4 antibody-mediated diseases of the central nervous system. Endothelin-1 (ET-1) is an inflammatory cytokine released by vascular endothelial cells and activated astrocytes. Previous studies have reported the aberrant expressions of cytokines/chemokines in patients diagnosed with NMOSD. However, the serum levels of ET-1 in NMOSD patients remain unknown. The purpose of this study was to measure the serum levels of ET-1 and other immune-related cytokines/chemokines in patients with NMOSD, and to investigate the correlation between serum ET-1 levels and clinical characteristics of NMOSD...
May 2020: Immunobiology
https://read.qxmd.com/read/32517074/guanine-deaminase-in-human-epidermal-keratinocytes-contributes-to-skin-pigmentation
#47
Joon Min Jung, Tai Kyung Noh, Soo Youn Jo, Su Yeon Kim, Youngsup Song, Young-Hoon Kim, Sung Eun Chang
Epidermal keratinocytes are considered as the most important neighboring cells that modify melanogenesis. Our previous study used microarray to show that guanine deaminase (GDA) gene expression is highly increased in melasma lesions. Hence, we investigated the role of GDA in skin pigmentation. We examined GDA expression in post-inflammatory hyperpigmentation (PIH) lesions, diagnosed as Riehl's melanosis. We further investigated the possible role of keratinocyte-derived GDA in melanogenesis by quantitative PCR, immunofluorescence staining, small interfering RNA-based GDA knockdown, and adenovirus-mediated GDA overexpression...
June 5, 2020: Molecules: a Journal of Synthetic Chemistry and Natural Product Chemistry
https://read.qxmd.com/read/32515702/-vasculotoxicity-of-chemotherapy-assessment-%C3%B0-f-endothelial-dysfunction-biomarkers-levels-in-gastric-cancer-patients
#48
Yu Yu Kirichenko, Yu N Belenkov, E V Privalova, Yu I Naymann, E P Gitel, O V Novikova, I S Ilgisonis
Aim To evaluate dynamics of biomarkers for endothelial dysfunction (ED), including endothelin-1 (ET-1) and von Willebrand factor (VWF) in patients with stomach cancer (adenocarcinoma) before and after polychemotherapy (PCT); to compare these results with respective values in healthy volunteers and patients with cardiovascular diseases (CVD); to study correlations of the ED biomarkers with indexes of instrumental evaluation of endothelial dysfunction.Material and methods The study included 75 participants, including 25 healthy volunteers (control group), 25 patients with documented CVDs (arterial hypertension + ischemic heart disease), and 25 patients of the main group with histologically documented stage II-IV stomach cancer (adenocarcinoma) who received different courses of PCT with platinum-based agents (oxaliplatin, cisplatin) and fluoropyrimidines (5 fluorouracil, capecitabin)...
June 2, 2020: Kardiologiia
https://read.qxmd.com/read/32515639/serum-levels-of-vasoactive-factors-in-hiv-infected-pre-eclamptic-women-on-haart
#49
Isaac Ajadi, Kaminee Maduray, Simeon Eche, Premjith Gathiram, Irene Mackraj
In South Africa, pre-eclampsia (PE) and human immunodeficiency virus (HIV) infection are major causes of pregnancy-related deaths. This study aimed to measure serum levels of endothelin-1 (ET-1), endothelial nitric oxide synthase (eNOS), soluble fms-like tyrosine kinase 1 (sFlt-1), soluble endoglin (sEng) and placental growth factor (PlGF) in HIV-infected highly active antiretroviral therapy (HAART)-treated and HIV-uninfected PE and normotensive women to ascertain if HIV/HAART alters their concentrations. Mean sFlt-1 levels were significantly up-regulated in the PE (HIV-uninfected 4...
June 9, 2020: Journal of Obstetrics and Gynaecology: the Journal of the Institute of Obstetrics and Gynaecology
https://read.qxmd.com/read/32510740/the-roles-of-autophagy-in-osteogenic-differentiation-in-rat-ligamentum-fibroblasts-evidence-and-possible-implications
#50
Yuehua Yang, Zunwen Lin, Jiangwei Cheng, Sheng Ding, Wei-Wei Mao, Sheng Shi, Biru Liang, Leisheng Jiang
Autophagy, a macromolecular degradation process, plays a pivotal role in cell differentiation and survival. This study was designed to investigate the role of autophagy in the osteogenic differentiation in ligamentum fibroblasts. Rat ligamentum fibroblasts were isolated from the posterior longitudinal ligament and cultured in osteogenic induction medium. Ultrastructural analysis, immunofluorescence assay, western blot, flow cytometry, and lysosomal activity assessment were performed to determine the presence and activity of autophagy in the cells...
June 8, 2020: FASEB Journal: Official Publication of the Federation of American Societies for Experimental Biology
https://read.qxmd.com/read/32510144/blood-orange-juice-consumption-increases-flow-mediated-dilation-in-adults-with-overweight-and-obesity-a-randomized-controlled-trial
#51
Lu Li, Gemma K Lyall, J Alberto Martinez-Blazquez, Fernando Vallejo, Francisco A Tomas-Barberan, Karen M Birch, Christine Boesch
BACKGROUND: Epidemiological studies have indicated an inverse association between citrus fruit consumption and cardiovascular disease (CVD) risk. There is, however, a paucity of data concerning effects of blood orange juice (BOJ) intake on endothelial function and cardiovascular risk biomarkers. OBJECTIVES: We examined short-term effects of BOJ on endothelial function, blood pressure, lipid profile, and inflammatory markers in healthy participants of European origin who were overweight or obese...
June 8, 2020: Journal of Nutrition
https://read.qxmd.com/read/32505521/efficacy-and-safety-of-the-classic-chinese-herbal-prescription-sanpian-decoction-on-migraine-meta-analysis
#52
Bingxin Wu, Hongyin Rao, Songbai Yang, Sanjin Cai, Lingjing Tan, Zhitao Feng, Zhigang Mei
OBJECTIVES: To evaluate the efficacy and safety of the classic Chinese herbal prescription Sanpian decoction for curing migraine. METHODS: Scopus, PubMed, EMBASE, SPRINGER LINK, China National Knowledge Infrastructure (CNKI), Weipu Database and WanFang Database were searched from inception through January 2019 to identify randomized controlled trials (RCTs) that evaluated the efficacy and safety of Sanpian decoction. RESULTS: Fifteen RCTs with a total of 1377 participants were identified...
May 18, 2020: Explore: the Journal of Science and Healing
https://read.qxmd.com/read/32499477/association-of-138i-d-and-lys198asn-polymorphisms-in-the-endothelin-1-gene-with-early-onset-of-coronary-artery-disease-among-the-chinese-han-population
#53
Guosheng Tu, Zhengxu Fang, Yu Zhao, Qinghua Wu
BACKGROUND Human endothelin-1 (ET-1) gene polymorphism is closely associated with coronary artery disease (CAD). This study aimed to investigate the association of 2 single-nucleotide polymorphisms (SNPs), +138 I/D and Lys198Asn) of the ET-1 gene,with early onset of CAD in Han Chinese patients. We investigated the effects of Lys198Asn polymorphism on ET-1 protein expression upon stimulation with pro-inflammatory factors. MATERIAL AND METHODS Genotyping of the 2 SNPs +138 I/D and Lys198Asn was performed in 88 early-onset CAD patients (≤55 years for males; ≤60 years for females) and 52 healthy control participants using a polymerase chain reaction direct sequencing method...
June 5, 2020: Medical Science Monitor: International Medical Journal of Experimental and Clinical Research
https://read.qxmd.com/read/32496677/-pulmonary-arterial-hypertension-pah-a-new-era-of-pulmonary-arterial-vasodilatators
#54
J Guiot, O Cornia, R Louis
Pulmonary arterial hypertension (PAH) is a rare disease, characterized by a progressive increase in pulmonary arterial pressure. The therapeutic management of PAH patients has evolved significantly over the past decades following the appearance of new specific therapies, but also the performance of multiple clinical studies in an otherwise rare pathology. As a result, the care is very well codified and makes it possible to treat all patients at best. To date, we can cite four therapeutic families: endothelin receptor antagonists (ERA), drugs that interfere with the cyclic guanosine monophosphate (cGMP) pathway such as phosphodiesterase type 5 inhibitors (PDE5i) or the stimulator of soluble guanylate cyclase, prostacyclin analogues, and, finally, calcium antagonists...
May 2020: Revue Médicale de Liège
https://read.qxmd.com/read/32496159/diabetes-related-sex-differences-in-the-brain-endothelin-system-following-ischemia-in-vivo-and-in-human-brain-endothelial-cells-in-vitro
#55
Yasir Abdul, Weiguo Li, Juan David Vargas, Emily Grant, Lianying He, Sarah Jamil, Adviye Ergul
The endothelin (ET) system has been implicated to contribute to the pathophysiology of cognitive impairment and stroke in experimental diabetes. Our goals were to test the hypotheses that 1) circulating and/or peri-infarct ET-1 levels are elevated after stroke in both sexes and this increase is greater in diabetes, 2) ET receptors are differentially regulated in the diabetic brain, 3) brain microvascular endothelial cells (BMVEC) of female and male origin express the ETA receptor subtype, and 4) diabetes and stroke-mimicking conditions increase ET-1 levels in BMVECs of both sexes...
June 4, 2020: Canadian Journal of Physiology and Pharmacology
https://read.qxmd.com/read/32489641/mechanical-forces-alter-endothelin-1-signaling-comparative-ovine-models-of-congenital-heart-disease
#56
Terry Zhu, Samuel Chiacchia, Rebecca J Kameny, Antoni Garcia De Herreros, Wenhui Gong, Gary W Raff, Jason B Boehme, Emin Maltepe, Juan C Lasheras, Stephen M Black, Sanjeev A Datar, Jeffrey R Fineman
The risk and progression of pulmonary vascular disease in patients with congenital heart disease is dependent on the hemodynamics associated with different lesions. However, the underlying mechanisms are not understood. Endothelin-1 is a potent vasoconstrictor that plays a key role in the pathology of pulmonary vascular disease. We utilized two ovine models of congenital heart disease: (1) fetal aortopulmonary graft placement (shunt), resulting in increased flow and pressure; and (2) fetal ligation of the left pulmonary artery resulting in increased flow and normal pressure to the right lung, to investigate the hypothesis that high pressure and flow, but not flow alone, upregulates endothelin-1 signaling...
April 2020: Pulmonary Circulation
https://read.qxmd.com/read/32489640/a-non-selective-endothelin-receptor-antagonist-bosentan-modulates-kinetics-of-bone-marrow-derived-cells-in-ameliorating-pulmonary-hypertension-in-mice
#57
Taichi Kato, Yoshihide Mitani, Masahiro Masuya, Junko Maruyama, Hirofumi Sawada, Hiroyuki Ohashi, Yukiko Ikeyama, Shoichiro Otsuki, Noriko Yodoya, Tsutomu Shinohara, Eri Miyata, Erquan Zhang, Naoyuki Katayama, Hideto Shimpo, Kazuo Maruyama, Yoshihiro Komada, Masahiro Hirayama
The aim of this study was to investigate whether a dual endothelin receptor antagonist bosentan modulates the kinetics of bone marrow-derived stem cells in inhibiting the development of pulmonary hypertension. Bone marrow chimeric mice, transplanted with enhanced green fluorescent protein (eGFP)-positive bone marrow mononuclear cells, were exposed to hypobaric hypoxia or kept in the ambient air, and were daily treated with bosentan sodium salt or saline for 21 days. After the treatment period, right ventricular pressure was measured and pulmonary vascular morphometry was conducted...
April 2020: Pulmonary Circulation
https://read.qxmd.com/read/32487560/renomedullary-interstitial-cell-endothelin-a-receptors-regulate-bp-and-renal-function
#58
Chunyan Hu, Jayalakshmi Lakshmipathi, Deborah Stuart, Janos Peti-Peterdi, Georgina Gyarmati, Chuan-Ming Hao, Peter Hansell, Donald E Kohan
BACKGROUND: The physiologic role of renomedullary interstitial cells, which are uniquely and abundantly found in the renal inner medulla, is largely unknown. Endothelin A receptors regulate multiple aspects of renomedullary interstitial cell function in vitro . METHODS: To assess the effect of targeting renomedullary interstitial cell endothelin A receptors in vivo , we generated a mouse knockout model with inducible disruption of renomedullary interstitial cell endothelin A receptors at 3 months of age...
June 2, 2020: Journal of the American Society of Nephrology: JASN
https://read.qxmd.com/read/32487059/changes-in-reveal-risk-score-in-patients-with-pulmonary-arterial-hypertension-treated-with-macitentan-in-clinical-practice-results-from-the-pracma-study
#59
Pilar Escribano-Subias, Raquel López, Luis Almenar, María Lázaro, Ian Forn, Anna Torrent, Isabel Blanco, Joan Albert Barberà
BACKGROUND: Macitentan is a dual endothelin receptor antagonist indicated for the long-term treatment of pulmonary arterial hypertension (PAH). We evaluated the change over time in REVEAL risk score in incident and prevalent patients receiving macitentan for the first time. METHODS: Retrospective, observational study including adult patients with idiopathic/heritable PAH or PAH associated with connective tissue disorders or congenital heart disease treated with macitentan for ≥6-month follow-up in Spain...
June 2, 2020: BMC Pulmonary Medicine
https://read.qxmd.com/read/32481405/down-regulation-of-edn1-gene-expression-by-circulating-mir-206-is-associated-with-risk-of-preeclampsia
#60
Chunzhi Sheng, Yangchun Zhao, Libo Zhu
To study the correlation between circulating microRNA-206 (miR-206) levels and endothelin-1 (ET-1) levels, and to explore its association with preeclampsia (PE) risk.Reverse transcription-PCR (RT-PCT) was used to compare the plasma miR-206 levels in 200 PE patients and 200 healthy controls. The correlation between miR-206 and ET-1 levels in plasma of PE patients was analyzed by Pearson analysis. MiR-206 was transfected into human umbilical vein endothelial cells cells and ET-1 expression was analyzed by enzyme-linked immunosorbent assay...
May 29, 2020: Medicine (Baltimore)
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