Jeanne Mandelblatt, Jeffrey L Dage, Xingtao Zhou, Brent J Small, Tim A Ahles, Jaeil Ahn, Ashley Artese, Traci N Bethea, Elizabeth C Breen, Judith E Carroll, Harvey J Cohen, Martine Extermann, Deena Graham, Claudine Isaacs, Heather S L Jim, Brenna C Mcdonald, Zev M Nakamura, Sunita K Patel, G William Rebeck, Kelly E Rentscher, James C Root, Kristen A Russ, Danielle B Tometich, R Scott Turner, Kathleen Van Dyk, Wanting Zhai, Li-Wen Huang, Andrew J Saykin
PURPOSE: We evaluated whether plasma Alzheimer's Disease (AD)-related biomarkers were associated with cancer-related cognitive decline (CRCD) among older breast cancer survivors. METHODS: We included survivors 60-90 years with primary stage 0-III breast cancers (n = 236) and frequency-matched non-cancer controls (n = 154) who passed a cognitive screen and had banked plasma specimens. Participants were assessed at baseline (pre-systemic therapy) and annually for up to 60-months...
May 24, 2024: Journal of the National Cancer Institute