Jae Jung Lee, Jung Han Yoon, Sang Jin Kim, Han Soo Yoo, Seok Jong Chung, Yang Hyun Lee, Suk Yun Kang, Hae-Won Shin, Sook Keun Song, Jin Yong Hong, MunKyung Sunwoo, Ji Eun Lee, Jong Sam Baik, Young H Sohn, Phil Hyu Lee
The aim of this trial was to investigate the safety, tolerability, and capability of serum uric acid (UA) elevation of inosine 5'-monophosphate (IMP) in multiple system atrophy (MSA). The IMPROVE-MSA trial was a randomized, double-blind, placebo-controlled trial in MSA patients with no history of hyperuricemia-related disorders. The participants were assigned to placebo (n=25) or IMP (n=30) in a 1 to 1 ratio, and then followed up for 24 weeks. The primary endpoints included safety, tolerability, and alteration of the serum UA level during the follow-up period...
October 16, 2020: Clinical Pharmacology and Therapeutics
Qing Wu, Meizhen Liu, Ming Yu, Jianfei Fu
OBJECTIVE: There have been studies investigating sex differences in clinical manifestation of Parkinson's disease (PD). However, sex differences in underweight and body mass index (BMI) in de novo PD patients lacked systematic study. We aimed to compare sex differences in clinical features and related factors of underweight and BMI in Chinese de novo PD patients. MATERIALS AND METHODS: A total of 253 untreated PD inpatients and 218 controls were recruited from Ningbo...
October 16, 2020: Brain and Behavior
Fang Ran, Feng Liu, Ying Zhang, Linyun Chen
BACKGROUND: Cognitive impairment induced by cerebral infarction has become a devastating health problem. More efficient predictors are required to evaluate the potential cognitive decline after cerebral infarction in clinic. Serum uric acid (UA) and high-sensitivity C-reactive protein (hs-CRP) are two factors reported to correlate with cognitive impairment. However, the understanding on serum UA and hs-CRP with cognitive dysfunction remains unclear. METHODS: Serum UA and hs-CRP were evaluated in patients with cerebral infarction (n = 197) using single factor analysis and multivariate logistic regression analysis...
October 5, 2020: Dementia and Geriatric Cognitive Disorders
Weihua Niu, Huifeng Yang, Chengzhi Lu
BACKGROUND: Evidence has shown that serum uric acid (UA) is associated with cognitive function, but this finding remains debatable. Serum UA is commonly elevated in patients with chronic heart failure (CHF), especially in men. However, the relationship between serum UA and cognitive function in CHF populations and stratified by sex are unclear. We aimed to examine whether serum UA was independently associated with cognitive function in CHF populations after controlling for demographic, medical and psychological variables and whether there was a sex difference in the association between serum UA and cognitive function among male and female CHF patients...
August 20, 2020: BMC Cardiovascular Disorders
H K Aggarwal, Deepak Jain, Aswvini Bhavikatti
Cognitive impairment is a common entity in patients with chronic kidney disease (CKD), which plays an important role in increasing the morbidity in these patients. This study was performed to evaluate cognitive dysfunction and its severity in different stages of CKD and identify the correlation with factors affecting this dysfunction. A cross-sectional design study was conducted on 100 patients with CKD Stage III to V-D fulfilling the eligibility criteria. Cognitive status was assessed using the mini-mental state examination (MMSE) and Montreal cognitive assessment (MoCA) tests...
July 2020: Saudi Journal of Kidney Diseases and Transplantation
Ben Schöttker, Sabine Kuznia, Dana Clarissa Laetsch, David Czock, Annette Kopp-Schneider, Reiner Caspari, Hermann Brenner
BACKGROUND: Cancer-related fatigue represents one major cause of reduced quality of life in cancer patients and can seriously affect the physical, emotional, and cognitive functioning impeding coping with the disease. Options for effective treatment of cancer-related fatigue are limited, consisting only of non-pharmacologic interventions like physical activity, psychosocial, and mind-body interventions. Recent evidence suggests that vitamin D3 supplementation might alleviate cancer-related fatigue...
August 8, 2020: BMC Cancer
Jee Wook Kim, Min Soo Byun, Dahyun Yi, Jun Ho Lee, So Yeon Jeon, Kang Ko, Gijung Jung, Han Na Lee, Jun-Young Lee, Chul-Ho Sohn, Yun-Sang Lee, Seong A Shin, Yu Kyeong Kim, Dong Young Lee
Background: Despite known associations of lower serum uric acid (UA) with Alzheimer's disease (AD) dementia or AD-related cognitive impairment, little is known regarding the underlying patho-mechanisms. We aimed to examine the relationships of serum UA with in vivo AD pathologies including cerebral beta-amyloid (Aβ) and tau deposition, AD-signature region cerebral glucose metabolism (AD-CM), and white matter hyperintensities (WMH). We also investigated the association between serum UA and cognitive performance, and then assessed whether such an association is mediated by the brain pathologies...
2020: Frontiers in Aging Neuroscience
Nafija Serdarevic, Adina Elena Stanciu, Lejla Begic, Snezana Uncanin
Introduction: Significance of serum uric acid (UA) in cerebrovascular disease still remains controversial. UA is most abundant natural antioxidant in human plasma. Its antioxidant properties might protect against free radical damage, thereby reducing the risk of oxidative stress-related cognitive impairment and dementia. Aim: In our investigation, we determine the level of UA in 100 male patients diagnosed with the first ischemic brain stroke (blood samples were collected during the acute phase and post-acute phase), 100 male patients diagnosed with vascular dementia and 100 male healthy volunteers (control group)...
April 2020: Medical Archives
Silvia Lai, Sandro Mazzaferro, Maurizio Muscaritoli, Daniela Mastroluca, Massimo Testorio, Adolfo Perrotta, Ylenia Esposito, Maria Carta, Linda Campagna, Marta Di Grado, Cesarina Ramaccini, Sabrina De Leo, Alessandro Galani, Maria Ida Amabile, Alessio Molfino
A relationship between dysbiotic gut microbiome and chronic kidney disease (CKD) has been recently documented; it contributes to CKD-related complications, including cardiovascular disease. Aim: We tested how a low-protein diet (LPD)-with or without oral inulin supplementation as a prebiotic-modulates some inflammatory, atherosclerosis and endothelial dysfunction indices and nutritional markers, as well as psychocognitive functions in CKD patients. We conducted a prospective, case-control study on CKD patients on conservative therapy, divided in two groups: the intervention group treated with LPD (0...
June 9, 2020: Toxins
Jing Sun, Xinhuang Lv, Xinxin Gao, Zewei Chen, Dianhui Wei, Yi Ling, Junmei Zhang, Qilu Gu, Jiaming Liu, Weian Chen, Suzhi Liu
Post-stroke cognitive impairment (PSCI) is a severe complication of stroke. Predicting PSCI is difficult because some risk factors for stroke, such as blood glucose level and blood pressure, are affected by many other elements. Although recent studies have shown that high serum uric acid (UA) levels are associated with cognitive dysfunction and may be a risk factor for PSCI, its impact remains unclear. Accordingly, the present study aimed to explore the association between serum UA level and PSCI. In total, 274 patients who experienced acute cerebral infarction, confirmed between January 2016 and December 2018, were enrolled...
May 30, 2020: Neuroscience Letters
Aniqa B Alam, Aozhou Wu, Melinda C Power, Nancy A West, Alvaro Alonso
INTRODUCTION: Elevated serum uric acid (SUA) is associated with cardiovascular risk factors, which often contribute to dementia and dementia-like morbidity, yet several cross-sectional studies have shown protective associations with cognition, which would be consistent with other work showing benefits of elevated SUA through its antioxidant properties. METHODS: We studied 11,169 participants free of dementia and cardiovascular disease from the Atherosclerosis Risk in Communities (ARIC) cohort...
April 28, 2020: Journal of the Neurological Sciences
Hee-Jin Kim, Il Woong Sohn, Young Seo Kim, Jae-Bum Jun
In an elderly population with cognitive impairment, we investigated the association between serum uric acid (sUA) and serum homocysteine (sHcy), known risk factors for cerebrovascular disease. We also investigated the potential effect of the C677T polymorphism in the gene encoding methylenetetrahydrofolate reductase (MTHFR) to the sUA level in different dementia types. Participants underwent a battery of tests including measurements of sUA, sHcy, folic acid, and vitamin B12 as well as genotyping of the MTHFR locus...
April 19, 2020: Nutrients
Virginia Boccardi, Silvia Carino, Elisa Marinelli, Maria Lapenna, Giulia Caironi, Anna Rita Bianco, Roberta Cecchetti, Carmelinda Ruggiero, Patrizia Mecocci
BACKGROUND: It has been suggested that oxidative stress may have a role in the pathogenesis of Alzheimer's disease (AD). Serum uric acid (UA) could exert neuroprotective effects via its antioxidant capacities. Many studies investigated serum UA levels in subjects with AD, but to date, results are conflicting and evidence in old age subjects is weak. AIMS: In this study, we assess whether serum UA levels would be altered in the AD old age subjects compared to those of initial cognitive impairment and healthy controls...
April 10, 2020: Aging Clinical and Experimental Research
Long Wang, Xue-Min Zhao, Xiao-Zheng Yuan, Fu-Yu Wang, Jun -Shen, Yu Wang
OBJECTIVES: To observed the relationship between serum 25-hydroxyvitamin D (25-(OH) D) and different cognitive domains and evaluated the predictive value of 25-(OH) D level for cognitive impairment in patients with white matter lesions (WML). METHODS: The Mini-mental State Examination (MMSE) and the Montreal Cognitive Assessment (MoCA) were used to evaluate cognitive function in patients with WML. The differences in clinical data including 25-(OH) D were analysed between cognitive normality (n=87) and impairment (n=139) groups and variant cognitive domains analysed between groups of different levels of serum 25-(OH) D...
March 3, 2020: Medical Principles and Practice: International Journal of the Kuwait University, Health Science Centre
Jing Zhang, Lijuan Tang, Jun Hu, Yuwei Wang, Yuzhen Xu
BACKGROUND: Elevated serum uric acid (SUA) has been associated with vascular cognitive impairment (CI) in the elderly. However, its relationship with cognitive function in the elderly patients receiving maintenance hemodialysis (MHD) has not yet been elucidated. OBJECTIVE: The cognitive impairment is prevalent in MHD patients. Various insults may contribute to cognitive impairment in patients with MHD. The aim of this study was to investigate the relationship between SUA and CI in the elderly patients receiving MHD...
January 27, 2020: Brain and Behavior
Silvia Lai, Luigi Petramala, Maurizio Muscaritoli, Rosario Cianci, Sandro Mazzaferro, Anna Paola Mitterhofer, Marzia Pasquali, Viola D'Ambrosio, Maria Carta, Matteo Ansuini, Cesarina Ramaccini, Alessandro Galani, Maria Ida Amabile, Alessio Molfino, Claudio Letizia
OBJECTIVES: Autosomal dominant polycystic kidney disease (ADPKD) is the most common genetic kidney disease characterized by multiple and bilateral cystic dilation of renal tubules. Hypertension, endothelial dysfunction, systemic inflammation, and accelerated atherosclerosis are alterations found at a very early stage of the disease and are responsible for increasing both cardiovascular risks and progression toward end-stage renal disease. The aim of the study was to evaluate the effects of the use of 1...
September 27, 2019: Nutrition
Michael Lawton, Fahd Baig, Greg Toulson, Alireza Morovat, Samuel G Evetts, Yoav Ben-Shlomo, Michele T Hu
BACKGROUND: Predicting prognosis in Parkinson's disease (PD) has important implications for individual prognostication and clinical trials design and targeting novel treatments. Blood biomarkers could help in this endeavor. METHODS: We identified 4 blood biomarkers that might predict prognosis: apolipoprotein A1, C-reactive protein, uric acid and vitamin D. These biomarkers were measured in baseline serum from 624 Parkinson's disease subjects (median disease duration, 1...
February 2020: Movement Disorders: Official Journal of the Movement Disorder Society
Anthoula Efstathiadou, Dipender Gill, Frances McGrane, Terence Quinn, Jesse Dawson
Background Higher serum uric acid levels are associated with cardiovascular and neurovascular disease, but whether these relationships are causal is not known. We applied Mendelian randomization approaches to assess the association between genetically determined uric acid levels and outcomes under study in large clinical trials. Methods and Results We used 28 genetic variants related to serum uric acid as instruments to perform a range of 2-sample Mendelian randomization methods. Our analysis had statistical power to detect clinically relevant effects of genetically determined serum uric acid levels on the considered clinical outcomes; cognitive function, Alzheimer disease, coronary heart disease, myocardial infarction, systolic blood pressure, and stroke...
September 3, 2019: Journal of the American Heart Association
Li Lin, Li Juan Zheng, U Joseph Schoepf, Akos Varga-Szemes, Rock H Savage, Yun Fei Wang, Han Zhang, Xin Yuan Zhang, Guang Ming Lu, Long Jiang Zhang
Objective: To explore the relationship among serum uric acid (SUA) levels in different states of disease, human cognition, and spontaneous brain activities by resting-state functional MRI (rs-fMRI). Methods: We prospectively recruited 100 subjects (age 58 ± 11 years, 55 females) who underwent fasting blood sampling, cognitive tests and rs-fMRI scans. The subjects were divided into two groups by sex and each sex group was further stratified into three subgroups according to SUA level in different states of disease...
2019: Frontiers in Neuroscience
Rong Huang, Sai Tian, Jing Han, Hongyan Lin, Dan Guo, Jiaqi Wang, Ke An, Shaohua Wang
BACKGROUND: Serum uric acid (SUA) is a natural antioxidant that may exert neuroprotective effects against neurodegenerative diseases. The relationship between uric acid and cognitive functions has been extensively studied, but results remain conflicting. OBJECTIVE: To investigate potential associations between SUA level and mild cognitive impairment (MCI), and different domains of cognitive performances in patients with type 2 diabetes mellitus (T2DM). METHODS: A total of 352 T2DM subjects (208 males and 144 females) were enrolled...
April 1, 2019: Journal of Alzheimer's Disease: JAD
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