Pooja Suresh Poojary, Guruprasad Nayak, Gangotri Panchanan, Arpitha Rao, Sanjna Das Kundapur, Sneha Guruprasad Kalthur, Srinivas Mutalik, Satish Kumar Adiga, Yulian Zhao, Jamie Bakkum-Gamez, Alice Y Chang, Christopher DeStephano, Mark Sherman, Nagarajan Kannan, Guruprasad Kalthur
Polycystic ovarian syndrome (PCOS) is a complex health condition associated with metabolic disturbances and infertility. Recent data suggest that the prevalence of PCOS is increasing among women globally, although the etiology of these trends is undefined. Consequently, preclinical models that better reflect the biology of PCOS are urgently needed to facilitate research that can lead to the discovery of prevention strategies or improved management. The existing animal models have several limitations as they do not reflect all the PCOS features metabolically and/or phenotypically...
September 1, 2022: Endocrinology