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COMPARATIVE STUDY
Masashi Kadohisa, Yukihiro Inomata, Keita Shimata, Kaori Isono, Masaki Honda, Shintaro Hayashida, Yuki Ohya, Hidekazu Yamamoto, Hideaki Okajima, Taizo Hibi
OBJECTIVES: Donor safety is paramount in living donor liver transplantation. However, there remains a risk of postoperative complications for some donors. Here, we provide a comprehensive assessment of donor morbidity by a single team with 17 years of experience at a single center. MATERIALS AND METHODS: We retrospectively reviewed 453 donor hepatectomies of living donor liver transplants at Kumamoto University from August 2000 to March 2017. Posterior segment graft cases were excluded in this study...
March 2024: Experimental and Clinical Transplantation
#2
JOURNAL ARTICLE
Khalid Mahmood, Ahsan Ahmad, Rohit Upadhyay, Takallum Khatoon, Zaid Imbisat, Ankur Akela
BACKGROUND AND OBJECTIVES: End-stage renal disease (ESRD) rates are on the rise globally, including in India. However, the affordability of dialysis treatment remains a significant challenge for many, with costs varying across different regions. Although cost-effective, kidney transplantation faces challenges like a surgeon shortage, lack of infrastructure, and lack of logistic support. The study examines Indian laparoscopic nephrectomy outcomes and their benefits for donor recovery. It covers kidney donor procedural details, demographics, preoperative health evaluations, complications, and one-month follow-up...
March 2024: Curēus
#3
JOURNAL ARTICLE
Keita Shimata, Young-In Yoon, Taizo Hibi, Jun Morinaga, Anila Kutty Narayanan, Takeo Toshima, Takashi Ito, Nobuhisa Akamatsu, Yoshihito Kotera, Suk Kyun Hong, Yasushi Hasegawa, Yuzo Umeda, Mettu Srinivas Reddy, Aldwin De Leon Ong, Saraswathy Sivaprasadan, Joy Varghese, Yasuhiko Sugawara, Chao-Long Chen, Kyung-Suk Suh, Toru Ikegami, Kwang-Woong Lee, Sung-Gyu Lee, Surendran Sudhindran, Tomoharu Yoshizumi, Etsuro Hatano, Shinya Okumura, Kiyoshi Hasegawa, Hiroto Egawa, Hideaki Obara, Kazuya Yasui, Yasuhiro Ogura, Kanta Jobara, Hiroyuki Nitta, Hirokatsu Katagiri, Masayuki Otsuka, Satoshi Kuboki, Susumu Eguchi, Takanobu Hara, Hidetoshi Eguchi, Kazuki Sasaki, Taku Aoki, Hideki Ohdan, Masahiro Ohira, Yasutsugu Takada, Kohei Ogawa, Takumi Fukumoto, Kaori Kuramitsu, Akio Saiura, Hirofumi Ichida, Takuya Hashimoto, Shigeru Marubashi, Naoya Sato, Hidetaka Ushigome, Shumpei Harada, Yuji Soejima, Yuichi Masuda, Mitsuo Shimada, Yu Saitou, Akinobu Taketomi, Ryoichi Goto, Tsuyoshi Shimamura, Shugo Mizuno, Akihiro Tanemura, Itaru Endo, Michiaki Unno, Shigehito Miyagi, Yukiyasu Okamura, Osamu Aramaki, Kenichi Hakamada, Keinosuke Ishido, Yutaro Kato, Takeshi Takahara, Mitsuhisa Takatsuki, Shinichiro Ono
Liver transplantation is often the only lifesaving option for acute liver failure (ALF); however, the predictors of short-term mortality (death within one year) after living donor liver transplantation (LDLT) for ALF have yet to be defined. We retrospectively collected patients ≥18 years old who underwent LDLT for ALF between 2010 and 2020 at 35 centers in Asia. Univariate and multivariate logistic regression analyses were conducted to identify the clinical variables related to short-term mortality and establish a novel scoring system...
April 29, 2024: American Journal of Transplantation
#4
JOURNAL ARTICLE
Yueh-Tse Wu, Li-Min Hu, Chao-Wei Lee, Wei-Chen Lee, Jr-Rung Lin, Hsin-I Tsai, Huang-Ping Yu
BACKGROUND: Liver transplantation is treatment option for patients with end stage liver disease and hepatocellular carcinoma. Renal function deterioration significantly impacts the survival rates of liver recipients, and serum uric acid (SUA) is associated with both acute and chronic renal function disorders. Thus, our study aimed to assess the relationship and predictive value of preoperative SUA level and postoperative acute kidney injury (AKI) in living donor liver transplantation (LDLT)...
May 1, 2024: Journal of the Chinese Medical Association: JCMA
#5
JOURNAL ARTICLE
Christie Rampersad, Curie Ahn, Chris Callaghan, Beatriz Dominguez-Gil, Gustavo F Ferreira, Vivek Kute, Axel O Rahmel, Minnie Sarwal, Jon Snyder, Haibo Wang, Germaine Wong, S Joseph Kim
BACKGROUND: The current landscape of organ donation and transplantation (ODT) registries is not well established. This narrative review sought to identify and characterize the coverage, structure, and data capture of ODT registries globally. METHODS: We conducted a literature search using Ovid Medline and web searches to identify ODT registries from 2000 to 2023. A list of ODT registries was compiled based on publications of registry design, studies, and reports...
April 30, 2024: Transplantation
#6
JOURNAL ARTICLE
Cheng-Maw Ho, Po-Huang Lee, Hou-Ying Cheng, Chih-Yang Hsaio, Yao-Ming Wu, Ming-Chih Ho, Rey-Heng Hu
BACKGROUND: Wailitst lost is an critical issue and we investigated the long-term effect of insufficient liver functional reserve at liver transplantation evaluation on waitlist outcomes in patients with hepatocellular carcinoma (HCC). METHODS: Clinical data of patients with HCC waitlisted for liver transplantation were retrospectively collected from a single hospital cohort during the period from 2014 to 2021. Parameters of liver reserve, including cirrhosis, Child-Pugh grade, and Model for End-Stage Liver Disease (MELD) scores, were analyzed for patient survival, after adjustment for tumor factors...
April 29, 2024: Langenbeck's Archives of Surgery
#7
RANDOMIZED CONTROLLED TRIAL
Yasin Dalda, Sami Akbulut, Tevfik Tolga Sahin, Adem Tuncer, Zeki Ogut, Basri Satilmis, Ozlem Dalda, Mehmet Gul, Sezai Yilmaz
Background and Objectives : The aim of this study is to evaluate the clinical and laboratory changes of ischemia and reperfusion injury in the remnant livers of donors with and without Pringle maneuver. Furthermore, we evaluated the recipients who have been transplanted with liver grafts from these donors. Methods and Materials : A total of 108 patients (54 living liver donors and 54 liver recipients) who underwent donor hepatectomy and recipients who living donor liver transplantation, were included in this randomized double-blind study between February 2021 and June 2021...
April 18, 2024: Medicina
#8
JOURNAL ARTICLE
Namkee Oh, Jae-Hun Kim, Jinsoo Rhu, Woo Kyoung Jeong, Gyu-Seong Choi, Jong Man Kim, Jae-Won Joh
BACKGROUND: This study aimed to develop an automated segmentation system for biliary structures using a deep learning model, based on data from magnetic resonance cholangiopancreatography (MRCP). MATERIALS AND METHODS: Living liver donors who underwent MRCP using the gradient and spin echo technique followed by three-dimensional modeling were eligible for this study. A three-dimensional residual U-Net model was implemented for the deep learning process. Data were divided into training and test sets at a 9:1 ratio...
April 1, 2024: International Journal of Surgery
#9
JOURNAL ARTICLE
Abu Bakar H Bhatti, Syeda F Qasim, Zamrood Zamrood, Shahzad Riyaz, Nusrat Y Khan, Haseeb H Zia, Muslim Atiq
BACKGROUND AND OBJECTIVES: Acute-on-chronic liver failure (ACLF) is associated with high short-term mortality without liver transplantation (LT). The selection criteria for LT in these patients are not well defined. The objective of this study was to determine factors associated with post-transplant survival in ACLF. METHODS: This was a single-center retrospective study of patients who underwent living donor liver transplantation (LDLT) for ACLF between 2012 and 2022...
2024: Journal of Clinical and Experimental Hepatology
#10
JOURNAL ARTICLE
Prediction of early recovery of graft function after living donor liver transplantation in children.
Bingqian Tan, Chenyu Yang, Jiqiang Hu, Huiwu Xing, Mingman Zhang
For end-stage liver disease in children, living donor liver transplantation (LDLT) is often the important standard curative treatment. However, there is a lack of research on early recovery of graft function after pediatric LDLT. This is a single-center, ambispective cohort study. We collected the demographic and clinicopathological data of donors and recipients, and determined the risk factors of postoperative delayed recovery of hepatic function (DRHF) by univariate and multivariate Logistic analyses. 181 cases were included in the retrospective cohort and 50 cases in the prospective cohort...
April 24, 2024: Scientific Reports
#11
JOURNAL ARTICLE
Yuliya Semenova, Altynay Beyembetova, Saule Shaisultanova, Aruzhan Asanova, Aliya Sailybayeva, Sholpan Altynova, Yuriy Pya
There is a scarcity of publications evaluating the performance of the national liver transplantation (LTx) program in Kazakhstan. Spanning from 2012 to 2023, it delves into historical trends in LTx surgeries, liver transplant centers, and the national cohort of patients awaiting LTx. Survival analysis for those awaiting LTx, using life tables and Kaplan-Meier, is complemented by time series analysis projecting developments until 2030. The overall per million population (pmp) LTx rate varied from 0.35 to 3.77, predominantly favoring living donor LTx...
April 23, 2024: Scientific Reports
#12
JOURNAL ARTICLE
Sung Hyun Cho, Ho Seung Lee, Gunn Huh, Dongwook Oh, Tae Jun Song, Dong-Wan Seo, Sung Koo Lee
BACKGROUND AND AIMS: Endoscopic multiple plastic stents are an established first-line treatment for anastomotic biliary stricture (ABS) management after liver transplantation (LT). Fully covered self-expandable metallic stents (FCSEMSs) have recently been used with favorable outcomes, but long-term treatment outcomes remain an issue for ABS. We evaluated the long-term outcomes of FCSEMS for the management of refractory ABS after LT. METHODS: We reviewed the prospectively collected and maintained endoscopic retrograde cholangiography database at Asan Medical Center to retrieve consecutive post-LT ABS cases that underwent an endoscopic FCSEMS placement between August 2009 and August 2019 after MPS placement failure...
April 22, 2024: Surgical Endoscopy
#13
JOURNAL ARTICLE
Yuan-Chen Chang, Kuang-Chen Yen, Po-Chin Liang, Ming-Chih Ho, Cheng-Maw Ho, Chih-Yang Hsiao, Chiu-Han Hsiao, Chia-Hsun Lu, Chih-Horng Wu
BACKGROUND: Preoperative imaging evaluation of liver volume and hepatic steatosis for the donor affects transplantation outcomes. However, computed tomography (CT) for liver volumetry and magnetic resonance spectroscopy (MRS) for hepatic steatosis are time consuming. Therefore, we investigated the correlation of automated 3D-multi-echo-Dixon sequence magnetic resonance imaging (ME-Dixon MRI) and its derived proton density fat fraction (MRI-PDFF) with CT liver volumetry and MRS hepatic steatosis measurements in living liver donors...
April 19, 2024: Journal of the Formosan Medical Association
#14
JOURNAL ARTICLE
Iker Uriarte, Eva Santamaria, Amaya López-Pascual, María J Monte, Josepmaria Argemí, M Ujue Latasa, Elena Adán-Villaescusa, Ainara Irigaray, Jose M Herranz, María Arechederra, Jorge Basualdo, Felipe Lucena, Fernando J Corrales, Fernando Rotellar, Fernando Pardo, Gregory Merlen, Dominique Rainteau, Bruno Sangro, Thierry Tordjmann, Carmen Berasain, Jose J G Marín, Maite G Fernández-Barrena, Ignacio Herrero, Matias A Avila
BACKGROUND AND AIMS: Liver regeneration is essential for the preservation of homeostasis and survival. Bile acids (BAs)-mediated signaling is necessary for liver regeneration, but BAs levels need to be carefully controlled to avoid hepatotoxicity. We studied the early response of the BAs-fibroblast growth factor 19 (FGF19) axis in healthy individuals undergoing hepatectomy for living donor liver transplant. We also evaluated BAs synthesis in mice upon partial hepatectomy (PH) and acute inflammation, focusing on the regulation of cytochrome-7A1 (CYP7A1), a key enzyme in BAs synthesis from cholesterol...
April 19, 2024: Biochimica et Biophysica Acta. Molecular Basis of Disease
#15
JOURNAL ARTICLE
Deok-Gie Kim, Sung Hwa Kim, Jun Young Lee, Jae Geun Lee
BACKGROUND: Evidence for the long-term use of antiplatelet drugs to prevent hepatic vascular complications (HVC) is scarce in liver transplantation (LT). METHODS: From national claim data, LT recipients (about 80 % of living donor LT [LDLT]) without graft loss, HVC, or cardiovascular events within 1 year, were classified into those who took antiplatelets for ≥1 year (n = 1744) and for <1 year (n = 1975). Outcomes were compared after the 1-postoperative year index time point...
April 18, 2024: Asian Journal of Surgery
#16
JOURNAL ARTICLE
Muthukumarassamy Rajakannu, Ashwin Rammohan, Gomathy Narasimhan, Sivakumar Murugesan, Rajesh Rajalingam, Kumar Palaniappan, Sandeep Jasper Rajasekar, Dinesh Jothimani, Akila Rajakumar, Ilankumaran Kaliamoorthy, Mohamed Rela
BACKGROUND: Paucity of deceased donor livers has resulted in a 10-fold rise in living donor liver transplantations (LDLTs) performed in India over the past decade. Nonetheless, number of deceased donor liver transplantation (DDLT) performed has improved with the establishment of simplified legal framework for certification of brain death and organ donation. In this study, we present our outcomes of DDLT performed at various centers, comparing their outcomes and provide a snapshot of the increasing number of DDLT across the state over the years...
April 19, 2024: Transplantation
#17
JOURNAL ARTICLE
Cristal Brown, Callaghan Ray, Garrett Kuketz, John Virostko
BACKGROUND: Metabolic factors have a significant role in the morbidity and mortality associated with chronic liver disease. The pancreas has a central role in metabolism and metabolic risk factors but has been largely ignored in liver transplantation. Small pancreas volume has been demonstrated in pathologic conditions such as type 1 and 2 diabetes. METHODS: This study assessed abdominal imaging before and after liver transplantation to determine if liver transplantation induces changes in pancreas volume in living donor liver transplant recipients...
April 19, 2024: Transplantation
#18
JOURNAL ARTICLE
Shohei Yoshiya, Shinji Itoh, Takeo Toshima, Takuma Izumi, Norifumi Iseda, Yuriko Tsutsui, Katsuya Toshida, Yuki Nakayama, Takuma Ishikawa, Yasushi Tanaka, Mizuki Ninomiya, Tomoharu Yoshizumi
AIM: Although the incidence of overweight and obese recipients and donors is increasing worldwide, few reports have focused on outcomes of preoperative weight reduction (WR) in living-donor liver transplantation (LDLT). We therefore examined the outcomes and the impact of WR on the postoperative course. METHODS: We analyzed 217 consecutive LDLT procedures performed from 2017 to 2022. We divided the recipients and donors into a WR group and non-WR group. RESULTS: Twenty-two recipients (10...
April 15, 2024: Journal of Gastrointestinal Surgery
#19
JOURNAL ARTICLE
Shailesh Sable, Vibha Varma, Sorabh Kapoor, Samriddhi Poyekar, Barun Nath, Vinay Kumaran
BACKGROUND: Living donor liver transplant (LDLT) is based on the principle of double equipoise. Organ shortage in Asian countries has led to development of high-volume LDLT programs with good outcomes. Safety of live liver donor is the Achilles heel of LDLT program and every effort should be made to achieve low morbidity and near zero mortality rates. METHODS: We retrospectively analyzed our prospectively maintained donor morbidity data (outcomes) of 177 donors in a new transplant program setup in western India by an experienced surgeon...
April 17, 2024: Indian Journal of Gastroenterology: Official Journal of the Indian Society of Gastroenterology
#20
JOURNAL ARTICLE
Mohamed Rela, Ashwin Rammohan, Rajesh Rajalingam, Pierre-Alain Clavien
The hepatic blood supply and its several homeostatic and pathologic processes has always been a matter of great interest. Many views commonly held today are derived from an earlier era, but major reorientations have occurred recently in almost all aspects of knowledge of the role and regulation of hepatic blood flow. Moreover, with the advent of liver transplantation (LT), especially living donor LT (LDLT) there has been a resurgence of interest in attempting to comprehend this deceptively simple topic. It is nonetheless important to concede that even though our knowledge on the practical modulation of hepatic hemodynamics has expanded enormously, there still remain the need to explore the depths of our remaining ignorance to further improve outcomes in LDLT...
April 16, 2024: Annals of Surgery
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