Shabnum Shaheen, Sana Khalid, Khadija Aaliya, Ambreen Gul, Amna Hafeez, Muhammad Armaghan, Zainab M Almarhoon, Daniela Calina, Khushbukhat Khan, Javad Sharifi-Rad
Nimbolide, one of the main ingredients constituent of Azadirachta indica (neem) leaf extract, has garnered attention for its potential as an anticancer agent. Its efficacy against various cancers and chemopreventive action has been demonstrated through numerous in vivo and in vitro studies. This updated review aims to comprehensively explore the chemopreventive and anticancer properties of nimbolide, emphasizing its molecular mechanisms of action and potential therapeutic applications in oncology. The review synthesizes evidence from various studies that examine nimbolide's roles in apoptosis induction, anti-proliferation, cell death, metastasis inhibition, angiogenesis suppression, and modulation of carcinogen-metabolizing enzymes...
May 18, 2024: Medical Oncology