G Li, Q Li, Z Shen, X Lin, X Li, J Wang, B Zhao, Y Feng, L Feng, W Guo, L Hu, J Wang, C Zhang, Z Fan, S Wang, X Wu
In humans, teeth are replaced only once, and the successional dental lamina (SDL) of the permanent tooth is maintained in a quiescent state until adolescence. Recently, we showed that biomechanical stress generated by the rapid growth of the deciduous tooth inhibits SDL development via integrin β1-RUNX2 signaling at embryonic day 60 (E60) in miniature pigs. However, the mechanism by which RUNX2 regulates SDL initiation within the SDL stem cell niche remains unclear. In the current study, we transcriptionally profiled single cells from SDL and surrounding mesenchyme at E60 and identified the landscape of cellular heterogeneity...
July 14, 2023: Journal of Dental Research