Eleni Panagiotakaki, Francesco D Tiziano, Mohamad A Mikati, Lisanne S Vijfhuizen, Sophie Nicole, Gaetan Lesca, Emanuela Abiusi, Agnese Novelli, Lorena Di Pietro, Aster V E Harder, Nicole M Walley, Elisa De Grandis, Anne-Lise Poulat, Vincent Des Portes, Anne Lépine, Marie-Cecile Nassogne, Alexis Arzimanoglou, Rosaria Vavassori, Jan Koenderink, Christopher H Thompson, Alfred L George, Fiorella Gurrieri, Arn M J M van den Maagdenberg, Erin L Heinzen
Alternating hemiplegia of childhood (AHC) is a rare neurodevelopment disorder that is typically characterized by debilitating episodic attacks of hemiplegia, seizures, and intellectual disability. Over 85% of individuals with AHC have a de novo missense variant in ATP1A3 encoding the catalytic α3 subunit of neuronal Na+/ K+ ATPases. The remainder of the patients are genetically unexplained. Here, we used next-generation sequencing to search for the genetic cause of 26 ATP1A3-negative index patients with a clinical presentation of AHC or an AHC-like phenotype...
December 14, 2023: European Journal of Human Genetics: EJHG