Miroslawa Gorecka, Gerry P McCann, Colin Berry, Vanessa M Ferreira, James C Moon, Christopher A Miller, Amedeo Chiribiri, Sanjay Prasad, Marc R Dweck, Chiara Bucciarelli-Ducci, Dana Dawson, Marianna Fontana, Peter W Macfarlane, Alex McConnachie, Stefan Neubauer, John P Greenwood
BACKGROUND: Although coronavirus disease 2019 (COVID-19) is primarily a respiratory illness, myocardial injury is increasingly reported and associated with adverse outcomes. However, the pathophysiology, extent of myocardial injury and clinical significance remains unclear. METHODS: COVID-HEART is a UK, multicentre, prospective, observational, longitudinal cohort study of patients with confirmed COVID-19 and elevated troponin (sex-specific > 99th centile)...
June 10, 2021: Journal of Cardiovascular Magnetic Resonance
Nicola Galea, Livia Marchitelli, Giacomo Pambianchi, Federica Catapano, Giulia Cundari, Lucia Ilaria Birtolo, Viviana Maestrini, Massimo Mancone, Francesco Fedele, Carlo Catalano, Marco Francone
BACKGROUND: Early detection of myocardial involvement can be relevant in coronavirus disease 2019 (COVID-19) patients to timely target symptomatic treatment and decrease the occurrence of the cardiac sequelae of the infection. The aim of the present study was to assess the clinical value of cardiovascular magnetic resonance (CMR) in characterizing myocardial damage in active COVID-19 patients, through the correlation between qualitative and quantitative imaging biomarkers with clinical and laboratory evidence of myocardial injury...
June 10, 2021: Journal of Cardiovascular Magnetic Resonance
Zeynep Yapan Emren, Volkan Emren, Emre Özdemir, Uğur Karagöz, Cem Nazlı
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the global coronavirus disease 2019 (COVID-19) pandemic. Although the virus predominantly causes respiratory system infection, recent reports have shown that it is also associated with many cardiovascular complications. It has been reported that COVID-19 may cause myocarditis, type 1 and 2 acute myocardial infarction, and thrombotic complications.[1] Spontaneous coronary artery dissection (SCAD) is a rare form of coronary artery disease that has recently been associated with COVID-19 in a few case reports...
June 2021: Türk Kardiyoloji Derneği Arşivi: Türk Kardiyoloji Derneğinin Yayın Organıdır
Danny Ramzy, Mark Anderson, George Batsides, Masahiro Ono, Scott Silvestry, David A D'Alessandro, Masaki Funamoto, Elias A Zias, Anthony Lemaire, Edward Soltese
OBJECTIVE: To report the initial clinical experience with the Impella 5.5® with SmartAssist® , a temporary left ventricular assist device that provides up to 6.2 L/min forward flow, with recent FDA approval for up to 14 days. METHODS: From October 2019 to March 2020, 200 patients at 42 US centers received the Impella 5.5 and entered into the IQ registry, a manufacturer-maintained quality database that captures limited baseline/procedural characteristics and outcomes through device explant...
June 8, 2021: Innovations: Technology and Techniques in Cardiothoracic and Vascular Surgery
Raed A Alsatli
Coronavirus disease-2019 (COVID-19) is a world epidemic disease and is caused by severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2). In addition to the respiratory manifestations, it may also cause cardiovascular complications, such as, myocarditis, arrhythmias, myocardial infarction, heart failure, and venous thromboembolic events. This review article will discuss in detail pathophysiology, manifestations, and management of these cardiac complications. A literature review was performed, it included meta-analyses studies, cohort studies, publications, and case series from the largest COVID-19 outbreak centers around the world...
July 2020: Anesthesia, Essays and Researches
Nora F Fnon, Hanan H Hassan, Mahrous A Ibrahim
Diagnosis of the underlying cause of sudden unexpected death in a previously healthy individual remains one of the important challenges in forensic practice. Ischemic heart disease is the most common cause of sudden death. The current study aims to investigate the incidence and pathology of sudden ischemic cardiac death in Egypt. All cases of sudden cardiac death (SCD) examined by different forensic departments throughout Egypt during the period of January 2010 through December 2014 were included. Cases underwent complete autopsy examination including a thorough gross and microscopic examination of the heart and great blood vessels...
June 5, 2021: American Journal of Forensic Medicine and Pathology
Francesco Pelliccia, Carl J Pepine, Colin Berry, Paolo G Camici
The role of cardiac magnetic resonance (CMR) in identifying mechanisms for myocardial infarction with non-obstructed coronary arteries (MINOCA) is well established. Recent reports have highlighted the potentially key role of invasive management in this diagnostic process. Intravascular ultrasound (IVUS) and optical coherence tomography (OCT) allow precise evaluation of coronary anatomy, and assessment of coronary physiology in the catheter laboratory provides information on the hemodynamic significance of sub-critical atherosclerosis and on coronary microvascular dysfunction (CMD)...
June 1, 2021: International Journal of Cardiology
Robert Sykes, Michael Briscoe, Thomas Krysztofiak, Oliver Peck, Kenneth Mangion, Colin Berry
BACKGROUND: Patients with type 2 myocardial infarction (T2MI) and other mechanisms of nonthrombotic myocardial injury have an unmet therapeutic need. Eligibility for novel medical therapy is generally uncertain. METHODS: We predefined colchicine, eplerenone and ticagrelor as candidates for repurposing towards novel therapy for T2MI or myocardial injury. Considering eligibility for randomisation in a clinical trial, each drug was classified according to indications and contraindications for therapy and survival for at least 24 hours following admission...
June 2021: Open Heart
Kyoko Imanaka-Yoshida
Tenascin-C (TNC) is a large extracellular matrix (ECM) glycoprotein and an original member of the matricellular protein family. TNC is transiently expressed in the heart during embryonic development, but is rarely detected in normal adults; however, its expression is strongly up-regulated with inflammation. Although neither TNC-knockout nor -overexpressing mice show a distinct phenotype, disease models using genetically engineered mice combined with in vitro experiments have revealed multiple significant roles for TNC in responses to injury and myocardial repair, particularly in the regulation of inflammation...
May 29, 2021: International Journal of Molecular Sciences
Roberta Esposito, Teresa Fedele, Silvia Orefice, Vittoria Cuomo, Maria Prastaro, Mario Enrico Canonico, Federica Ilardi, Francesco De Stefano, Ludovica Fiorillo, Ciro Santoro, Giovanni Esposito
Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that activate the immune system, aiming at enhancing antitumor immunity. ICIs have shown great promise in the treatment of several advanced malignancies. However, therapy with these immunomodulatory antibodies may lead to a wide spectrum of immune-related adverse events in any organ and any tissue. Cardiologic immune-related events include pericarditis, pericardial effusion, various types of arrhythmias including the occurrence of complete atrioventricular block, myocardial infarction, heart failure, and myocarditis...
May 22, 2021: Biomolecules
Jessica Castrillon Lal, Sherry-Ann Brown, Patrick Collier, Feixiong Cheng
BACKGROUND: Modern therapies in oncology have increased cancer survivorship, as well as the incidence of cardiovascular adverse events. While immune checkpoint inhibitors have shown significant clinical impact in several cancer types, the incidence of immune-related cardiovascular (CV) adverse events poses an additional health concern and has been reported. METHODS: We performed a retrospective analysis of the FDA Adverse Event Reporting System data of suspect product reports for immunotherapy and classical chemotherapy from January 2010-March 2020...
May 28, 2021: Cardio-Oncology
Yuan Cheng, Ligong Nie, Wei Ma, Bo Zheng
Myocarditis, arrhythmia, and cardiomyopathy are the most reported acute cardiotoxicities in cancer patients receiving immune checkpoint inhibitor (ICI) therapy. But it is not clear whether ICI can cause acute coronary occlusive disease. We reported acute coronary artery occlusion in an 83-year-old male non-small cell lung cancer (NSCLC) patient after 2 days of pembrolizumab infusion. This patient had a server-underlying three-vessel coronary artery disease without symptoms. The patient was discharged from the hospital two weeks after percutaneous coronary intervention...
May 27, 2021: Cardiovascular Toxicology
Rafael Blanco-Domínguez, Raquel Sánchez-Díaz, Hortensia de la Fuente, Luis J Jiménez-Borreguero, Adela Matesanz-Marín, Marta Relaño, Rosa Jiménez-Alejandre, Beatriz Linillos-Pradillo, Katerina Tsilingiri, María L Martín-Mariscal, Laura Alonso-Herranz, Guillermo Moreno, Roberto Martín-Asenjo, Marcos M García-Guimaraes, Katelyn A Bruno, Esteban Dauden, Isidoro González-Álvaro, Luisa M Villar-Guimerans, Amaia Martínez-León, Ane M Salvador-Garicano, Sam A Michelhaugh, Nasrien E Ibrahim, James L Januzzi, Jan Kottwitz, Sabino Iliceto, Mario Plebani, Cristina Basso, Anna Baritussio, Mara Seguso, Renzo Marcolongo, Mercedes Ricote, DeLisa Fairweather, Héctor Bueno, Leticia Fernández-Friera, Fernando Alfonso, Alida L P Caforio, Domingo A Pascual-Figal, Bettina Heidecker, Thomas F Lüscher, Saumya Das, Valentín Fuster, Borja Ibáñez, Francisco Sánchez-Madrid, Pilar Martín
BACKGROUND: The diagnosis of acute myocarditis typically requires either endomyocardial biopsy (which is invasive) or cardiovascular magnetic resonance imaging (which is not universally available). Additional approaches to diagnosis are desirable. We sought to identify a novel microRNA for the diagnosis of acute myocarditis. METHODS: To identify a microRNA specific for myocarditis, we performed microRNA microarray analyses and quantitative polymerase-chain-reaction (qPCR) assays in sorted CD4+ T cells and type 17 helper T (Th17) cells after inducing experimental autoimmune myocarditis or myocardial infarction in mice...
May 27, 2021: New England Journal of Medicine
Ayman R Fath, Amro Aglan, Kyle S Varkoly, Abdullah S Eldaly, Roxana N Beladi, Arnold Forlemu, Nawfal Mihyawi, Anup Solsi, Sharjeel Israr, Alexandra R Lucas
In this article, we report a case of a 61-year-old male who was diagnosed with SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2), presenting with acute respiratory distress syndrome requiring intubation and hemodynamic support, marked D-Dimer and troponin I elevation, worsening ST-elevation myocardial infarction on repeat electrocardiograms, and a negative coronary angiogram ruling out a coronary artery thrombosis or occlusion. With worsening diffuse ST-segment elevation on electrocardiograms and reduced ejection fraction on echocardiography in the setting of systemic inflammation, fulminant myocarditis was highly suspected...
January 2021: Journal of Investigative Medicine High Impact Case Reports
Aaron Schmid, Marija Petrovic, Kavya Akella, Anisha Pareddy, Sumathilatha Sakthi Velavan
COVID-19 was primarily identified as a respiratory illness, but reports of patients presenting initially with cardiovascular complaints are rapidly emerging. Many patients also develop cardiovascular complications during and after COVID-19 infection. Underlying cardiovascular disease increases the severity of COVID-19 infection; however, it is unclear if COVID-19 increases the risk of or causes cardiovascular complications in patients without preexisting cardiovascular disease. The review is aimed at informing the primary care physicians of the potential cardiovascular complications, especially in patients without underlying cardiovascular disease...
2021: International Journal of Vascular Medicine
Rashed Noor, Adiba Naz, Syeda Muntaka Maniha, Nafisa Tabassum, Tasmin Tabassum, Tahsin Tabassum, Masuma Afrin Taniya, Muntasir Billah
Cardiovascular diseases including myocardial infarctions, myocarditis, strokes, coronary artery disease, chronic granulomatous disease, atherosclerotic cardiovascular disease, etc. can be regarded as the severe health trouble round the globe. The reasons behind the heart related complications have been well chalked our so far. Interestingly, along with the non-infectious reasons, an array of bacteria, fungi, parasites and viruses is known to cause different types of heart complications. Unfortunately, the role of microorganisms in inducing heart diseases is not that much known by the mass community in the underdeveloped and even in the developing countries over the world...
April 30, 2021: Frontiers in Bioscience (Landmark Edition)
Sivabaskari Pasupathy, John F Beltrame
No abstract text is available yet for this article.
May 12, 2021: JACC. Cardiovascular Imaging
Kiera Liblik, Jin Byun, Clara Saldarriaga, Gonzalo E Perez, Ricardo Lopez-Santi, Fernando Q Wyss, Alvaro S Liprandi, Manuel Martinez-Sellés, Juan M Farina, Ivan Mendoza, Lucrecia M Burgos, Adrian Baranchuk
Snakebite envenomation is a neglected tropical disease which can result in morbidity and mortality. Cardiac implications are poorly understood due to the low frequency of cardiotoxicity combined with a lack of robust information, as snakebites commonly occur in remote and rural areas. This review aims to assess cardiovascular implications of snakebite envenoming and proposes an algorithm for screening of cardiovascular manifestations. A systematic review was performed and 29 articles relating to cardiovascular involvement in snakebite envenomation were selected...
April 3, 2021: Current Problems in Cardiology
Hira Maab, Faryal Mustafa, Syeda Javeria Shabbir
The novel coronavirus disease (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) dominantly infects the lungs, causing interstitial pneumonitis and severe acute respiratory distress syndrome (ARDS) however the cardiovascular implications of the infection are particularly significant, especially in their contribution to disease morbidity and mortality. SARS-CoV-2 enters the cardiovascular system by binding to the angiotensin-converting enzyme 2 (ACE2) receptor. The pathogenic cardiovascular mechanism of the virus involves systemic inflammation via a cytokine storm and direct myocardial injury...
May 12, 2021: Acta Bio-medica: Atenei Parmensis
Xia Wu, Leitao Huang, Jichun Liu
Diabetic cardiomyopathy (DCM) is the leading cause of death worldwide, and oxidative stress was discovered to serve an important role in the pathophysiology of the condition. An imbalance between free radicals and antioxidant defenses is known to be associated with cellular dysfunction, leading to the development of various types of cardiac disease. Nuclear factor-erythroid-2-related factor 2 (NRF2) is a transcription factor that controls the basal and inducible expression levels of various antioxidant genes and other cytoprotective phase II detoxifying enzymes, which are ubiquitously expressed in the cardiac system...
July 2021: Experimental and Therapeutic Medicine
Fetch more papers »
Fetching more papers... Fetching...
Remove bar
Read by QxMD icon Read

Save your favorite articles in one place with a free QxMD account.


Search Tips

Use Boolean operators: AND/OR

diabetic AND foot
diabetes OR diabetic

Exclude a word using the 'minus' sign

Virchow -triad

Use Parentheses

water AND (cup OR glass)

Add an asterisk (*) at end of a word to include word stems

Neuro* will search for Neurology, Neuroscientist, Neurological, and so on

Use quotes to search for an exact phrase

"primary prevention of cancer"
(heart or cardiac or cardio*) AND arrest -"American Heart Association"