Pascal Chiari, Olivier Desebbe, Michel Durand, Marc-Olivier Fischer, Diane Lena-Quintard, Jean-Charles Palao, Géraldine Samson, Yvonne Varillon, Bernadette Vaz, Pierre Joseph, Arnaud Ferraris, Matthias Jacquet-Lagreze, Matteo Pozzi, Delphine Maucort-Boulch, Michel Ovize, Gabriel Bidaux, Nathan Mewton, Jean-Luc Fellahi
OBJECTIVE: The ProCCard study tested whether combining several cardioprotective interventions would reduce the myocardial and other biological and clinical damage in patients undergoing cardiac surgery. DESIGN: Prospective, randomized, controlled trial. SETTING: Multicenter tertiary care hospitals. PARTICIPANTS: 210 patients scheduled to undergo aortic valve surgery. INTERVENTIONS: A control group (standard of care) was compared to a treated group combining five perioperative cardioprotective techniques: anesthesia with sevoflurane, remote ischemic preconditioning, close intraoperative blood glucose control, moderate respiratory acidosis (pH 7...
April 14, 2023: Journal of Cardiothoracic and Vascular Anesthesia