Use the keywords feature with a free QxMD account.
Use Read by QxMD to access full text via your institution or open access sources.
Read also provides personalized recommendations to keep you up to date in your field.
Existing User
Sign InNew to Read
Sign Up#1
David Sweet , Julian Marsden , Kendall Ho , Christina Krause , James A Russell
Many emergency departments have implemented sepsis protocols since the 2001 publication of results from the early goal-directed therapy trial, which showed early targeted resuscitation lowers mortality. As part of an attempt to improve clinical and operational outcomes for emergency departments across British Columbia, we reviewed sepsis management literature and considered sepsis protocol implementation in the province’s emergency departments. During the literature review we found that many observational studies confirmed an association between implementation of emergency sepsis protocols and decreased mortality...
May 2012: British Columbia Medical Journal
#2
JOURNAL ARTICLE
Cristobal Castillo-Aliaga, Susana Castro-Seriche, Alonso Jerez-Morales, Rachael Tarlinton
Feline Leukemia Virus is a retrovirus causing fatal disease in domestic cats. While FeLV has been controlled in many countries, it remains a major concern in Latin American countries. This study conducted an epidemiological survey of FeLV in 182 Chilean domestic cats using PCR to detect provirus infection. The results were analysed using Multivariate Logistic Regression to examine risk factors associated with FeLV detection. The FeLV prevalence was 54.95 %, and statistically significant associations (p < 0...
September 5, 2024: Research in Veterinary Science
#3
JOURNAL ARTICLE
Laura E Quintero-Martínez, Adrian Canizalez-Roman, Uriel A Angulo-Zamudio, Hector Flores-Villaseñor, Jorge A Velazquez-Roman, Jan G M Bolscher, Kamran Nazmi, Nidia Leon-Sicairos
Salmonellosis is a common foodborne disease caused by Salmonella bacteria. The emergence of multidrug-resistant (MDR) Salmonella serotypes, such as Typhimurium, and Salmonella's ability to form biofilms contribute to their resistance and persistence in host and non-host environments. New strategies are needed to treat or prevent Salmonella infections. This work aimed to determine the effect of the bovine lactoferrin (bLF) and lactoferrin chimera (LFchimera) in preventing or disrupting biofilms formed on abiotic surfaces or Caco-2 cells by Salmonella Typhimurium ATCC 14028 or an MDR strain...
September 18, 2024: Biochemistry and Cell Biology
#4
JOURNAL ARTICLE
Caroline Sköld, Jens Sörensen, Anders Brüggemann, Nils P Hailer
BACKGROUND: Several studies using positron emission tomography (PET) show highly elevated periprosthetic bone uptake of fluorine-18 sodium fluoride (18F-fluoride), suggestive of implant loosening after arthroplasty. Focus so far has been on qualitative but not on quantitative assessment. There is also a lack of intraoperative confirmation of preoperative 18F-fluoride PET findings. Although the method seems to have acceptable accuracy and high sensitivity, an attempt to improve the specificity and an overall validation of the method appear warranted...
September 11, 2024: Clinical Orthopaedics and related Research
#5
JOURNAL ARTICLE
Bei He, Bingqing Wang, Qingguo Zhang
BACKGROUND: The remnant ear is a very important material in auricular reconstruction surgery; its dimension, position, and shape determine how it is used. However, the local conditions of microtia patients are complex and variable. Situations may be encountered where a series of abnormal remnant ears cannot be utilized in clinical practice. Currently, there are no literature that elaborates on this type of microtia and provides systematic treatment methods. The purpose of this article is to systematically classify them and optimize the two-stage method auricular reconstruction, to provide an effective surgical method for these patients...
September 4, 2024: Annals of Plastic Surgery
#6
JOURNAL ARTICLE
Samuel Quarton, Alana Livesey, Charlotte Jeff, Christopher Hatton, Aaron Scott, Dhruv Parekh, David Thickett, Alan McNally, Elizabeth Sapey
BACKGROUND: Causative pathogens are currently identified in only a minority of pneumonia cases, which affects antimicrobial stewardship. Metagenomic next-generation sequencing (mNGS) has potential to enhance pathogen detection due to its sensitivity and broad applicability. However, while studies have shown improved sensitivity compared with conventional microbiological methods for pneumonia diagnosis, it remains unclear whether this can translate into clinical benefit. Most existing studies focus on patients who are ventilated, readily allowing for analysis of bronchoalveolar lavage fluid (BALF)...
September 18, 2024: JMIR Research Protocols
#7
JOURNAL ARTICLE
Jesica Martín-Carmona, Anaïs Corma-Gómez, Francisco Téllez, Dolores Arenga-Barrios, Miriam Serrano-Fuentes, Luis Morano, Diana Corona-Mata, Miguel Nicolás Navarrete Lorite, Francisco Jesús Vera-Méndez, Juan Carlos Alados, Rosario Palacios, Ignacio de Los Santos, Paloma Geijo, Arkaitz Imaz, Dolores Merino, Sergio Javier Reus-Bañuls, Maria Jose Galindo, Miguel Ángel López-Ruz, Carlos Galera, Juan A Pineda, Juan Macías
BACKGROUND: In patients with hepatitis C virus (HCV) chronic infection and advanced liver disease, the impact of human immunodeficiency virus (HIV) coinfection on the clinical outcome after sustained virological response (SVR) has not been sufficiently clarified. The aim of this study was to compare the mortality after SVR of patients bearing HCV chronic infection and advanced liver fibrosis, with and without HIV-coinfection after a prolonged follow-up. METHODS: This was a prospective multicenter cohort study including individuals with HIV/HCV-coinfection and patients with HCV-monoinfection from Spain, fulfilling: 1) Liver stiffness (LS) ≥9...
September 18, 2024: Clinical Infectious Diseases
#8
JOURNAL ARTICLE
Leah H Rubin, Erin N Shirk, Lily Pohlenz, Hayley Romero, Elizabeth Roti, Raha M Dastgheyb, Isabel Santiuste, Jennifer M Coughlin, Todd T Brown, Janice E Clements, Rebecca T Veenhuis
BACKGROUND: Monocytes are susceptible to HIV infection, form HIV reservoirs, and contribute to central nervous system complications (e.g., cognitive impairment) in virally suppressed women with HIV(vsWWH). However, it remains unknown if the quality and/or quantity of the monocyte reservoir contributes to cognition in vsWWH. METHODS: 62 vsWWH(mean age=56.1, SD=7.1; 93% Black, non-Hispanic; all HIV RNA <250 copies/mL) completed a cognitive test battery, blood draw, and whole blood immunophenotyping...
September 18, 2024: Journal of Infectious Diseases
#9
JOURNAL ARTICLE
Jin Zhao, Bin Wang, Meidan Zhao, Xinling Pan
BACKGROUND: Acute cholangitis is a clinical syndrome caused by a bacterial infection in the biliary system. The bacteria could exist in the bile before bile drainage despite empirical antibiotic treatment. METHODS: Patients with acute cholangitis admitted to a tertiary hospital in Southeastern China from August 2011 to September 2021 were involved when bile cultures were performed. Patient information before bile cultures and during hospitalization was extracted from the clinical record database...
September 11, 2024: European Journal of Gastroenterology & Hepatology
#10
JOURNAL ARTICLE
Sarita Choudhary, Sindhu Priya Vaddi, Arun Kumar Sharma, Kavita Vani, Sheetal Agarwal
No abstract text is available yet for this article.
September 18, 2024: Pediatric Infectious Disease Journal
#11
JOURNAL ARTICLE
Vaidehi Mehta, Ramsha Ansari, Ira Shah
Mixed tuberculosis occurs with multiple clonally distinct mycobacterium tuberculosis strains in an individual. We present a 12-year-old girl with steroid-resistant nephrotic syndrome and drug-sensitive pulmonary tuberculosis (Xpert MTB/Rif) and preextensively drug-resistant tuberculosis neuro-tuberculosis (Line Probe Assay). Mixed tuberculosis involving drug-susceptible and drug-resistant strains can hinder treatment. This case highlights the challenges in diagnosing mixed tuberculosis to ensure effective management...
September 18, 2024: Pediatric Infectious Disease Journal
#12
JOURNAL ARTICLE
Eleni Karakike, Simeon Metallidis, Garyfallia Poulakou, Maria Kosmidou, Nikolaos K Gatselis, Vasileios Petrakis, Nikoletta Rovina, Eleni Gkeka, Styliani Sympardi, Ilias Papanikolaou, Ioannis Koutsodimitropoulos, Vasiliki Tzavara, Georgios Adamis, Konstantinos Tsiakos, Vasilios Koulouras, Eleni Mouloudi, Eleni Antoniadou, Gykeria Vlachogianni, Souzana Anisoglou, Nikolaos Markou, Antonia Koutsoukou, Periklis Panagopoulos, Haralampos Milionis, George N Dalekos, Miltiades Kyprianou, Evangelos J Giamarellos-Bourboulis
OBJECTIVES: It is suggested that sepsis may be classified into four clinical phenotypes, using an algorithm employing 29 admission parameters. We applied a simplified phenotyping algorithm among patients with bacterial sepsis and severe COVID-19 and assessed characteristics and outcomes of the derived phenotypes. DESIGN: Retrospective analysis of data from prospective clinical studies. SETTING: Greek ICUs and Internal Medicine departments...
September 1, 2024: Critical care explorations
#13
JOURNAL ARTICLE
Anushka Saha, Trirupa Chakraborty, Javad Rahimikollu, Hanxi Xiao, Lorena B Pereira de Oliveira, Timothy W Hand, Sukwan Handali, W Evan Secor, Lucia A O Fraga, Jessica K Fairley, Jishnu Das, Aniruddh Sarkar
Schistosomiasis, a highly prevalent parasitic disease, affects more than 200 million people worldwide. Current diagnostics based on parasite egg detection in stool detect infection only at a late stage, and current antibody-based tests cannot distinguish past from current infection. Here, we developed and used a multiplexed antibody profiling platform to obtain a comprehensive repertoire of antihelminth humoral profiles including isotype, subclass, Fc receptor (FcR) binding, and glycosylation profiles of antigen-specific antibodies...
September 18, 2024: Science Translational Medicine
#14
JOURNAL ARTICLE
Benoît Manfroi, Bui Thi Cuc, Aurélien Sokal, Alexis Vandenberghe, Sarah Temmam, Mikaël Attia, Mohamed El Behi, Francesco Camaglia, Ngan Thu Nguyen, Jelka Pohar, Layale Salem-Wehbe, Valentine Pottez-Jouatte, Sibyline Borzakian, Narcisse Elenga, Caroline Galeotti, Guillaume Morelle, Camille de Truchis de Lays, Michaela Semeraro, Anne-Sophie Romain, Mélodie Aubart, Naim Ouldali, Florence Mahuteau-Betzer, Claire Beauvineau, Elsa Amouyal, Romain Berthaud, Célia Crétolle, Marc Duval Arnould, Albert Faye, Mathie Lorrot, Grégoire Benoist, Nelly Briand, Marie Courbebaisse, Roland Martin, Peter Van Endert, Jean-Sébastien Hulot, Anne Blanchard, Eric Tartour, Maria Leite-de-Moraes, Guillaume Lezmi, Mickael Ménager, Marine Luka, Claude-Agnès Reynaud, Jean-Claude Weill, Laetitia Languille, Marc Michel, Pascal Chappert, Thierry Mora, Aleksandra M Walczak, Marc Eloit, Petra Bacher, Alexander Scheffold, Matthieu Mahévas, Isabelle Sermet-Gaudelus, Simon Fillatreau
The development of the human immune system lasts for several years after birth. The impact of this maturation phase on the quality of adaptive immunity and the acquisition of immunological memory after infection at a young age remains incompletely defined. Here, using an antigen-reactive T cell (ARTE) assay and multidimensional flow cytometry, we profiled circulating severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)-reactive CD3+ CD4+ CD154+ T cells in children and adults before infection, during infection, and 11 months after infection, stratifying children into separate age groups and adults according to disease severity...
September 18, 2024: Science Translational Medicine
#15
JOURNAL ARTICLE
Markus Salbreiter, Annette Wagenhaus, Petra Rösch, Jürgen Popp
In the clinical environment, the identification of phylogenetic closely related genera and species like Clostridium and Bacillus spp. is challenging. Both genera contain representatives of pathogenic and nonpathogenic species that need to be distinguished for a proper diagnostic read-out. Therefore, reliable and accurate detection methods must be employed for the correct identification of these genera and species. Despite their high pathogenicity, clostridial infections and food contaminations present significant challenges due to their unique cultivation conditions and developmental needs...
September 18, 2024: Analytical Chemistry
#16
JOURNAL ARTICLE
Michael S Ohman, Emily R Albright, Christopher B Gelbmann, Robert F Kalejta
The Pentamer complex of Human Cytomegalovirus (HCMV) consists of the viral glycoproteins gH, gL, UL128, UL130, and UL131 and is incorporated into infectious virions. HCMV strains propagated extensively in vitro in fibroblasts carry UL128, UL130, or UL131 alleles that do not make a functional complex and thus lack Pentamer function. Adding functional Pentamer to such strains decreases virus growth in fibroblasts. Here, we show that the Pentamer inhibits productive HCMV replication in fibroblasts by repressing viral Immediate Early (IE) transcription...
September 24, 2024: Proceedings of the National Academy of Sciences of the United States of America
#17
JOURNAL ARTICLE
Yuepeng Zhang, Fabian Otte, Marcel Stoeckle, Alexander Thielen, Martin Däumer, Rolf Kaiser, Katharina Kusejko, Karin J Metzner, Thomas Klimkait
Even during extended periods of effective immunological control, a substantial dynamic of the viral genome can be observed in different cellular compartments in HIV-1 positive individuals, indicating the persistence of active viral reservoirs. To obtain further insights, we studied changes in the proviral as well as in the viral HIV-1 envelope (Env) sequence along with transcriptional, translational and viral outgrowth activity as indicators for viral dynamics and genomic intactness. Our study identified distinct reservoir patterns that either represented highly sequence-diverse HIV-1 populations or only a single / few persisting virus variants...
September 2024: PLoS Pathogens
#18
JOURNAL ARTICLE
Archana Koirala, Jocelynne McRae, Philip N Britton, Marnie Downes, Shayal A Prasad, Suellen Nicholson, Noni E Winkler, Matthew V N O'Sullivan, Fatima Gondalwala, Cecile Castellano, Emma Carey, Alexandra Hendry, Nigel Crawford, Ushma Wadia, Peter Richmond, Helen S Marshall, Julia E Clark, Joshua R Francis, Jeremy Carr, Adam Bartlett, Brendan McMullan, Justin Skowno, Donald Hannah, Andrew Davidson, Britta S von Ungern-Sternberg, Paul Lee-Archer, Laura L Burgoyne, Edith B Waugh, John B Carlin, Zin Naing, Nicole Kerly, Alissa McMinn, Guillian Hunter, Christine Heath, Natascha D'Angelo, Carolyn Finucane, Laura A Francis, Sonia Dougherty, William Rawlinson, Theo Karapanagiotidis, Natalie Cain, Rianne Brizuela, Christopher C Blyth, Nicholas Wood, Kristine Macartney
BACKGROUND: Following reduction of public health and social measures concurrent with SARS-CoV-2 Omicron emergence in late 2021 in Australia, COVID-19 case notification rates rose rapidly. As rates of direct viral testing and reporting dropped, true infection rates were most likely to be underestimated. OBJECTIVE: To better understand infection rates and immunity in this population, we aimed to estimate SARS-CoV-2 seroprevalence in Australians aged 0-19 years. METHODS: We conducted a national cross sectional serosurvey from June 1, 2022, to August 31, 2022, in children aged 0-19 years undergoing an anesthetic procedure at eight tertiary pediatric hospitals...
2024: PloS One
#19
JOURNAL ARTICLE
G Eric Bastien, Rachel N Cable, Cecelia Batterbee, A J Wing, Luis Zaman, Melissa B Duhaime
Viruses of microbes are ubiquitous biological entities that reprogram their hosts' metabolisms during infection in order to produce viral progeny, impacting the ecology and evolution of microbiomes with broad implications for human and environmental health. Advances in genome sequencing have led to the discovery of millions of novel viruses and an appreciation for the great diversity of viruses on Earth. Yet, with knowledge of only "who is there?" we fall short in our ability to infer the impacts of viruses on microbes at population, community, and ecosystem-scales...
September 18, 2024: PLoS Computational Biology
#20
JOURNAL ARTICLE
Mireille Ouedraogo, Jana Christina Hey, Stan Hilt, Veronica Rodriguez Fernandez, Doris Winter, Ravo Razafindrakoto, Pytsje T Hoekstra, Youssouf Kabore, Marco Fornili, Laura Baglietto, Issa Nebie, Govert J van Dam, Paul L A M Corstjens, Daniela Fusco, David Modiano, Fabrizio Bruschi, Valentina D Mangano
Infection with Schistosoma haematobium causes urogenital disease associated with organ disfunction, bleeding, pain, and higher susceptibility to infections and cancer. Timely and accurate diagnosis is crucial for prompt and appropriate treatment as well as surveillance efforts, and the use of plasma biomarkers offers important advantages over parasitological examination of urine, including increased sensitivity and the possibility to use the same specimen for multiple investigations. The present study aims to evaluate the diagnostic performance of different plasma biomarkers in endemic populations from Burkina Faso, West Africa...
September 18, 2024: PLoS Neglected Tropical Diseases
Make the most of Read.
Download the mobile app.
Download the mobile app.
Fetching more papers... 
