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JOURNAL ARTICLE
Nan Wang, Jing Li, Jianmin Ma
Giant cell reparative granuloma has a very low incidence and is thought to be a response to trauma. While there have been only a few reported cases of orbital giant cell reparative granuloma, we recently observed such a case and analyzed 16 previously reported cases of this type. It is important to note that further investigation is necessary to fully understand the relationship between giant cell reparative granuloma and trauma.
May 2024: Ophthalmic Plastic and Reconstructive Surgery
#22
JOURNAL ARTICLE
Tengyong Wang, Zihuai Wang, Jian Zhou, Zongyuan Li, Hu Liao, Jiandong Mei, Qiang Pu, Lunxu Liu
BACKGROUND: The efficacy of perioperative chemotherapy (PC) in pulmonary sarcomatoid carcinoma (PSC) is controversial. We conducted this study to investigate the effect of different histological subtypes on the efficacy of PC in PSC patients. METHODS: Clinicopathological data of 811 PSC patients of different histological subtypes were collected from the Surveillance, Epidemiology, and End Results (SEER) database. Kaplan-Meier method and log-rank test were used to evaluate the effects of PC on the overall survival (OS) and cancer-specific survival (CSS) in different subtypes of PSC patients...
April 29, 2024: Translational Lung Cancer Research
#23
Risimati Ephraim Rikhotso, Faheema Khan
INTRODUCTION AND IMPORTANCE: Maxillomandibular involvement with brown tumours is rare, especially in the paediatric population. We present a rare case of a young girl with brown tumour (BT) occurring in the mandible as the first manifestation of hyperparathyroidism. CASE PRESENTATION: A 7-year-old black female, presented with a 6-month history of a swelling on the left mandible. Patient had a history of intractable gastrointestinal symptoms such as nausea, vomiting and abdominal cramps...
May 8, 2024: International Journal of Surgery Case Reports
#24
JOURNAL ARTICLE
Davide Martorana, Ingeborg M Bajema
No abstract text is available yet for this article.
May 8, 2024: Lancet Rheumatology
#25
JOURNAL ARTICLE
Gonzalo Borrego-Yaniz, Lourdes Ortiz-Fernández, Adela Madrid-Paredes, Martin Kerick, José Hernández-Rodríguez, Sarah L Mackie, Augusto Vaglio, Santos Castañeda, Roser Solans, Jaume Mestre-Torres, Nader Khalidi, Carol A Langford, Steven Ytterberg, Lorenzo Beretta, Marcello Govoni, Giacomo Emmi, Marco A Cimmino, Torsten Witte, Thomas Neumann, Julia Holle, Verena Schönau, Gregory Pugnet, Thomas Papo, Julien Haroche, Alfred Mahr, Luc Mouthon, Øyvind Molberg, Andreas P Diamantopoulos, Alexandre Voskuyl, Thomas Daikeler, Christoph T Berger, Eamonn S Molloy, Daniel Blockmans, Yannick van Sleen, Mark Iles, Louise Sorensen, Raashid Luqmani, Gary Reynolds, Marwan Bukhari, Shweta Bhagat, Norberto Ortego-Centeno, Elisabeth Brouwer, Peter Lamprecht, Sebastian Klapa, Carlo Salvarani, Peter A Merkel, María C Cid, Miguel A González-Gay, Ann W Morgan, Javier Martin, Ana Márquez
BACKGROUND: Giant cell arteritis is an age-related vasculitis that mainly affects the aorta and its branches in individuals aged 50 years and older. Current options for diagnosis and treatment are scarce, highlighting the need to better understand its underlying pathogenesis. Genome-wide association studies (GWAS) have emerged as a powerful tool for unravelling the pathogenic mechanisms involved in complex diseases. We aimed to characterise the genetic basis of giant cell arteritis by performing the largest GWAS of this vasculitis to date and to assess the functional consequences and clinical implications of identified risk loci...
May 8, 2024: Lancet Rheumatology
#26
JOURNAL ARTICLE
Zhuoyao Xie, Huanmiao Zhao, Liwen Song, Qiang Ye, Liming Zhong, Shisi Li, Rui Zhang, Menghong Wang, Xiaqing Chen, Zixiao Lu, Wei Yang, Yinghua Zhao
PURPOSE: To develop a deep learning (DL) model for classifying histological types of primary bone tumors (PBTs) using radiographs and evaluate its clinical utility in assisting radiologists. METHODS: This retrospective study included 878 patients with pathologically confirmed PBTs from two centers (638, 77, 80, and 83 for the training, validation, internal test, and external test sets, respectively). We classified PBTs into five categories by histological types: chondrogenic tumors, osteogenic tumors, osteoclastic giant cell-rich tumors, other mesenchymal tumors of bone, or other histological types of PBTs...
May 7, 2024: European Journal of Radiology
#27
JOURNAL ARTICLE
Lauren Gyemi, Asher Selznick, Brad Petrisor, Michelle Ghert
PURPOSE: The primary objective of this study was to determine time to full weight-bearing after the use of a calcium-sulfate-calcium phosphate bone substitute (CaSO4/CaPO4) as a bone void filler in the treatment of primary benign bone tumours following intralesional curettage. The secondary objectives were to determine surgical complications and recurrence rates. METHODS: Retrospective review of patients identified from a surgeon-specific orthopaedic oncology database, who underwent curettage of benign bone tumours and subsequent bone void filling with CaSO4/CaPO4...
2024: Journal of Orthopaedic Surgery
#28
Camila Cordeiro Barbosa, Carlos Eduardo da Silva Ferreira Filho, Carlos Magno Chaves Oliveira, Tatiane Teles Albernaz Ferreira, Marilene de Farias Brito, Stella Maris Pereira de Melo, Milena Carolina Paz, Saulo Petinatti Pavarini, David Driemeier, José Diomedes Barbosa
This is the first report of parasitic granulomatous dermatitis caused by Pelodera spp. in a buffalo. The affected buffalo was about seven years old, was a female of the Murrah breed and belonged to a property located on Marajó Island in the State of Pará. During the clinical examination, the animal was in a standing position and presented several multifocal nodular and placoid masses throughout the body, mostly on the forelimbs, hindlimbs, abdomen, mammary glands, perineum, vulva and tail. These masses were also observed on the nasal mucosa, head, neck, back and chest...
April 29, 2024: Animals: An Open Access Journal From MDPI
#29
REVIEW
Roberto Cuomo, Warren M Rozen, Paola Pentangelo, Alessandra Ceccaroni, Carmine Alfano, Ishith Seth
Clear cell acanthoma (CCA) and squamous cell carcinoma (SCC) represent distinct entities within dermatological oncology, each posing unique diagnostic and therapeutic challenges. CCA is a rare, benign epidermal growth, often not associated with human papillomavirus (HPV) infection, whereas SCC, a more aggressive form of skin cancer, has been linked to both ultraviolet (UV) exposure and HPV. Understanding the co-occurrence of these conditions in a single patient can enhance diagnostic accuracy and therapeutic outcomes...
April 24, 2024: Journal of Clinical Medicine
#30
JOURNAL ARTICLE
Juan Jesus Vicente, Kainat Khan, Grant Tillinghast, José L McFaline-Figueroa, Yasemin Sancak, Nephi Stella
Microtubule targeting agents (MTAs) are commonly prescribed to treat cancers and predominantly kill cancer cells in mitosis. Significantly, some MTA-treated cancer cells escape death in mitosis, exit mitosis and become malignant polyploid giant cancer cells (PGCC). Considering the low number of cancer cells undergoing mitosis in tumor tissues, killing them in interphase may represent a favored antitumor approach. We discovered that ST-401, a mild inhibitor of microtubule (MT) assembly, preferentially kills cancer cells in interphase as opposed to mitosis, a cell death mechanism that avoids the development of PGCC...
May 10, 2024: Journal of Translational Medicine
#31
JOURNAL ARTICLE
Ruo-Xuan Sun, Zhen Hu, Xuewen Zhao, Ming-Jie Zha, Jinying Zhang, Xu-Dong Chen, Zhibo Liu, Jianguo Tian
As a second-order nonlinear optical phenomenon, the bulk photovoltaic (BPV) effect is expected to break through the Shockley-Queisser limit of thermodynamic photoelectron conversion and improve the energy conversion efficiency of photovoltaic cells. Here, we have successfully induced a strong flexo-photovoltaic (FPV) effect, a form of BPV effect, in strained violet phosphorene nanosheets (VPNS) by utilizing strain engineering at the h-BN nanoedge, which was first observed in nontransition metal dichalcogenide (TMD) systems...
May 10, 2024: ACS Nano
#32
Geoffrey T Murphy, Julie Shatz, S Fiona Bonar, Annabelle Mahar, Richard Boyle
No abstract text is available yet for this article.
May 10, 2024: ANZ Journal of Surgery
#33
JOURNAL ARTICLE
Julianne M Szczepanski, Joshua A Lieberman, Laura W Lamps, Raul S Gonzalez, Yue Xue, Xuchen Zhang, Osman H Yilmaz, John Hart, Thomas Krausz, Jose G Mantilla, Jonathan B McHugh, Maria Westerhoff
Mycobacterial spindle cell pseudotumors (MSPs) are a rare and diagnostically challenging manifestation of non-tuberculous mycobacterial (NTM) infections. Proper recognition of these pseudotumors is important because they are treatable and benign. In this study, we evaluated the morphologic patterns of MSPs to improve their pathologic identification. Clinical and morphologic features of 14 MSPs were analyzed. Histologic factors evaluated included the architectural growth pattern of spindled or epithelioid macrophages, granulomas and their location within the lesion, neutrophilic microabscesses, multinucleated giant cells, necrosis, and effacement of background tissue...
May 10, 2024: American Journal of Surgical Pathology
#34
Kylie T Callan, Amanda Anderson, Ryan Kim, Amanda Goldin, Naudereh Noori
Reconstruction options for giant cell tumors (GCTs) of bone are limited and challenging due to the amount of structural compromise and the high recurrence rates. This is especially true for GCTs of the foot and ankle, as the area is vital for weight bearing and function. The typical treatment for GCTs is currently excision, curettage, and cementation, although that is not always effective. A 36-year-old otherwise healthy female presented with an original diagnosis of a large aneurysmal bone cyst (ABC) of the distal tibia that had recurred despite two previous attempts at treatment with resection and cementation...
April 2024: Curēus
#35
JOURNAL ARTICLE
Vanessa Quick, Fran Benson, Sarah L Mackie
No abstract text is available yet for this article.
2024: Rheumatology Advances in Practice
#36
JOURNAL ARTICLE
Kiran Nasir, Aasim Ahmad
Renal angiomyolipomas (AMLs) and pulmonary lymphangioleiomyomatosis (LAM) are two major presentations of tuberous sclerosis (TS), an autosomal dominant multisystem disorder. Renal AMLs can lead to life-threatening complications like hemorrhage and cause progressive renal failure requiring dialysis and kidney transplant. mTOR inhibitors showed promising results in TS patients with renal AMLs, LAM, and subependymal giant cell astrocytomas. This case report is a follow-up of a patient we reported in 2010 with giant AMLs and LAM who required an emergency nephrectomy for massive hemorrhage from giant left-sided AMLs...
November 1, 2023: Saudi Journal of Kidney Diseases and Transplantation
#37
JOURNAL ARTICLE
Boquan Wan, Yiguo Lei, Zhixiang Yuan, Wei Wang
Microbiome in the intestines of aquatic invertebrates plays pivotal roles in maintaining intestinal homeostasis, especially when the host is exposed to pathogen invasion. Decapod iridescent virus 1 (DIV1) is a devastating virus seriously affecting the productivity and success of crustacean aquaculture. In this study, a metagenomic analysis was conducted to investigate the genomic sequences, community structure and functional characteristics of the intestinal microbiome in the giant river prawn Macrobrachiumrosenbergii infected with DIV1...
May 7, 2024: Fish & Shellfish Immunology
#38
JOURNAL ARTICLE
Hibbah Nabeel, Craig R Soderquist
No abstract text is available yet for this article.
May 9, 2024: Blood
#39
Srishti Manocha, Pranav Kataria, Nilansh Kataria, Rajesh Manocha
Giant cell arteritis (GCA) is a form of vasculitis characterized by symptoms that often lead a patient to consult a general dentist. Its rarity in the dental setting and serious life-altering effects make it a formidable diagnosis. We discuss a case of a 60-year-old female with GCA presenting with primary symptoms of excruciating tooth and jaw pain on the left side. We also report secondary symptoms of headache and partial vision loss and engage in a review of the relevant literature. Jaw pain, unexplained toothache, or tissue necrosis in patients aged over 50 years can be misdiagnosed as joint arthritis or temporomandibular disease (TMD), which could lead to severe consequences...
April 2024: Curēus
#40
Ali Z Ansari, Sahar Hafeez, Joel Jung, Srihita Patibandla, Peter S Kim, Michael Coffin, Alex Nguyen, Kurt Kratz
Chronic idiopathic ulcers of the colon pose diagnostic challenges due to their elusive etiology and potential resemblance to other intestinal pathologies, such as cecal carcinoma. This case report outlines the clinical course of a 68-year-old female patient who presented to the emergency department (ED) with persistent right lower quadrant pain. Despite multiple hospital visits yielding varied diagnoses, a definitive diagnosis was only made following a laparoscopic partial colectomy, which revealed chronic idiopathic ulcers with transmural scarring and adhesions to adjacent small intestine loops...
April 2024: Curēus
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