Nicolas Avellaneda, Gianluca Pellino, Annalisa Maroli, Anders Tottrup, Gabriele Bislenghi, Jan Colpaert, Andre D'Hoore, Michele Carvello, Lorenzo Giorgi, Patrizia Juachon, Sanne Harsløf, Anthony de Buck Van Overstraeten, Pablo A Olivera, Javier Gomez, Stefan D Holubar, Eddy Lincango Naranjo, Scott R Steele, Amit Merchea, Andrew Shaker, Marc Marti Gallostra, Miquel Kraft, Paulo Gustavo Kotze, Beatriz Yuki Maruyama, Steven D Wexner, Zoe Garoufalia, Zhihui Chen, Dieter Hahnloser, Djana Rrupa, Christianne Buskens, Anouck Haanappel, Janindra Warusavitarne, Katherine J Williams, Peter Christensen, Albert Wolthuis, Analia Potolicchio, Antonino Spinelli
AIM: Recent evidence challenges the current standard of offering surgery to patients with ileocaecal Crohn's disease (CD) only when they present complications of the disease. The aim of this study was to compare short-term results of patients who underwent primary ileocaecal resection for either inflammatory (luminal disease, earlier in the disease course) or complicated phenotypes, hypothesizing that the latter would be associated with worse postoperative outcomes. METHOD: A retrospective, multicentre comparative analysis was performed including patients operated on for primary ileocaecal CD at 12 referral centres...
June 10, 2024: Colorectal Disease
Zhipeng Li, Ziwei Zhao, Shujuan Chen, Xiaojuan Wang, Dongsheng Wang, Xiaoli Nie, Ye Yao
BACKGROUND: This study aimed to explore the mechanism of Ge-Gen-Qin-Lian decoction (GGQLD) in the alleviation of symptoms of type 2 diabetes mellitus (T2DM) with inflammatory bowel disease (IBD) by network pharmacology and experimental validation. METHODS: The active components and targets of GGQLD were identified from the TCMSP database. The potential therapeutic targets of T2DM and IBD were identified from the GEO database and 4 online disease target databases...
June 10, 2024: BMC complementary medicine and therapies
Arianna Polverino, Emahnuel Troisi Lopez, Roberta Minino, Antonella Romano, Agnese Miranda, Angela Facchiano, Lorenzo Cipriano, Pierpaolo Sorrentino
Although the aetio-pathogenesis of inflammatory bowel diseases (IBD) is not entirely clear, the interaction between genetic and adverse environmental factors may induce an intestinal dysbiosis, resulting in chronic inflammation having effects on the large-scale brain network. Here, we hypothesized inflammation-related changes in brain topology of IBD patients, regardless of the clinical form [ulcerative colitis (UC) or Crohn's disease (CD)]. To test this hypothesis, we analysed source-reconstructed magnetoencephalography (MEG) signals in 25 IBD patients (15 males, 10 females; mean age ± SD, 42...
June 10, 2024: European Journal of Neuroscience
Thomas W Dennison, Rachel D Edgar, Felicity Payne, Komal M Nayak, Alexander D B Ross, Aurelie Cenier, Claire Glemas, Federica Giachero, April R Foster, Rebecca Harris, Judith Kraiczy, Camilla Salvestrini, Georgia Stavrou, Franco Torrente, Kimberley Brook, Claire Trayers, Rasa Elmentaite, Gehad Youssef, Bálint Tél, Douglas James Winton, Nefeli Skoufou-Papoutsaki, Sam Adler, Philip Bufler, Aline Azabdaftari, Andreas Jenke, Natasha G, Natasha Thomas, Erasmo Miele, Abdulrahman Al-Mohammad, Greta Guarda, Subra Kugathasan, Suresh Venkateswaran, Menna R Clatworthy, Tomas Castro-Dopico, Ondrej Suchanek, Caterina Strisciuglio, Marco Gasparetto, Seokjun Lee, Xingze Xu, Erica Bello, Namshik Han, Daniel R Zerbino, Sarah A Teichmann, Josquin Nys, Robert Heuschkel, Francesca Perrone, Matthias Zilbauer
OBJECTIVE: Epigenetic mechanisms, including DNA methylation (DNAm), have been proposed to play a key role in Crohn's disease (CD) pathogenesis. However, the specific cell types and pathways affected as well as their potential impact on disease phenotype and outcome remain unknown. We set out to investigate the role of intestinal epithelial DNAm in CD pathogenesis. DESIGN: We generated 312 intestinal epithelial organoids (IEOs) from mucosal biopsies of 168 patients with CD (n=72), UC (n=23) and healthy controls (n=73)...
June 10, 2024: Gut
Marios Rossides, Susanna Kullberg, Elizabeth V Arkema
BACKGROUND: An autoimmune component in the etiology of sarcoidosis has long been debated, but population-based data on the clustering of immune-mediated diseases (IMD) and sarcoidosis in individuals and families suggestive of shared etiology is limited. RESEARCH QUESTION: Is there a higher risk of sarcoidosis having a history of IMDs and do IMDs cluster in sarcoidosis families? STUDY DESIGN AND METHODS: We conducted a case-control-family study (2001-2020)...
June 8, 2024: Chest
Victor Markus
Inflammatory Bowel Disease (IBD) is an enduring inflammatory disease of the gastrointestinal tract (GIT). The complexity of IBD, its profound impact on patient's quality of life, and its burden on healthcare systems necessitate continuing studies to elucidate its etiology, refine care strategies, improve treatment outcomes, and identify potential targets for novel therapeutic interventions. The discovery of a connection between IBD and gut bacterial quorum sensing (QS) molecules has opened exciting opportunities for research into IBD pathophysiology...
June 6, 2024: Biochemical and Biophysical Research Communications
Aldo J Montano-Loza, Christophe Corpechot, Patrizia Burra, Christoph Schramm, Nazia Selzner, Vincenzo Ronca, Ye H Oo
Autoimmune liver diseases (AILD) constitute the fourth most common indication for liver transplantation (LT) across the world. In general, the outcomes after LT are acceptable, however, disease recurrence post-LT is common for all AILD which can negatively affect graft and overall survival. Several questions persist, including the risk factors associated with recurrent disease, optimal anti-rejection medications, strategies to reduce the risk of recurrence, and how to best incorporate these strategies into clinical practice...
June 11, 2024: Liver Transplantation
(no author information available yet)
OBJECTIVE: An improved understanding of the causes and experience of diagnostic delay in Inflammatory Bowel Disease (IBD). METHODS: Framework analysis of semi-structured interviews with 20 adults with IBD. RESULTS: Participants' prior knowledge of normal bowel function/IBD was limited. Symptoms were sometimes misattributed to mild/transient conditions or normalised until intolerable. Family pressures, work, education, mistrust of doctors, fear and embarrassment could exacerbate delays...
2024: PloS One
Linrui Li, Mingyue Zhang, Moxiu Gu, Jun Li, Zhiyuan Li, Rong Zhang, Chuanwang Du, Yun Lv
OBJECTIVE: The aim of this study is to investigate the potential causal relationship between autoimmune diseases, including systemic lupus erythematosus, rheumatoid arthritis, inflammatory bowel disease, multiple sclerosis, and Type 1 diabetes, and age-related macular degeneration (AMD). By utilizing the two-sample Mendelian Randomization (MR) approach, we endeavor to address this complex medical issue. METHODS: Genome-wide association study (GWAS) data for autoimmune diseases and AMD were obtained from the IEU Open GWAS database and the FinnGen consortium...
2024: PloS One
Youyan Wang, Lipin Chen, Jierui Zhao, Guanghua Xia, Zhongyuan Liu, Haohao Shi
Astaxanthin (AST), mainly found in algae and shrimp, is a liposoluble ketone carotenoid with a wide range of biological activities and is commonly used in healthcare interventions and cosmetics. AST has a long chain of conjugated double bonds with hydroxyl and ketone groups at both ends, enabling it to form astaxanthin esters (AST-Es) through esterification with fatty acids. The fatty acid structure of AST plays a key role in the stability, antioxidant activity, and bioavailability of AST-Es. Antarctic krill ( Euphausia superba ) and blood-red algae Haematococcus Pluvialis ( H pluvialis )-derived AST-Es exhibit strong antioxidant activity and numerous biological activities, such as improving insulin resistance, preventing Parkinson's disease, regulating intestinal flora, and alleviating inflammatory bowel disease...
June 10, 2024: Journal of Agricultural and Food Chemistry
Xinyu Wang, Haoyu Qiu, Chengnan Chu, Kai Wang, Bitao Lu, Chao Yang, Baochen Liu, Guangqian Lan, Weiwei Ding
Noninvasive treatment of inflammatory bowel disease with lower gastrointestinal bleeding is a major clinical challenge. In this study, we designed an orally targeted microsphere based on sunflower pollen microcapsules to localize the site of inflammatory injury and promote hemostasis and tissue repair. Due to the Eudragit and ascorbate palmitate coatings, EL/AP@PS(t+Dex) demonstrates pH- and enzyme-responsive release of loaded drugs and helps to resist the harsh environment of the gastrointestinal tract. Both in vitro and in vivo experiments show the characteristics of inflammation targeting and mucosal adhesion, which reduce the systematic exposure and increase the local drug concentration...
June 10, 2024: ACS Applied Materials & Interfaces
Sarah Rotondo-Trivette, Xin-Yuan He, Jamil S Samaan, Fan Lv, Emily Truong, Michaela Juels, Anthony Nguyen, Xu Gao, Jian Zu, Yee Hui Yeo, Fan-Pu Ji, Gil Y Melmed
BACKGROUND: The coronavirus disease 2019 (COVID-19) pandemic disrupted healthcare in the United States. AIM: To investigate COVID-19-related and non-COVID-19-related death and characteristics associated with excess death among inflammatory bowel disease (IBD) decedents. METHODS: We performed a register-based study using data from the National Vital Statistics System, which reports death data from over 99% of the United States population, from January 1, 2006 through December 31, 2021...
May 28, 2024: World Journal of Gastroenterology: WJG
Zhang Wanyi, Yan Jiao, Huang Wen, Xu Bin, Wang Xuefei, Jiang Lan, Zhou Liuyin
Parkinson's disease (PD) and inflammatory bowel disease (IBD) are the two chronic inflammatory diseases that are increasingly affecting millions of people worldwide, posing a major challenge to public health. PD and IBD show similarities in epidemiology, genetics, immune response, and gut microbiota. Here, we review the pathophysiology of these two diseases, including genetic factors, immune system imbalance, changes in gut microbial composition, and the effects of microbial metabolites (especially short-chain fatty acids)...
2024: Frontiers in Neurology
Tejaswini Potlabathini, Mounica A Pothacamuri, Venkata Varshitha Bandi, Mahnoor Anjum, Parmendra Shah, M Molina, Nilashis Dutta, Oleksandr Adzhymuratov, Midhun Mathew, Vatsalya Sadu, Shiza A Zahid, Harini Lingamgunta, Monika Sahotra, Syed Muhammad Zain Jamil Nasiri, Christine Dawn M Daguipa
Rheumatoid arthritis (RA) is a complex autoimmune disease causing chronic joint inflammation and, in more serious cases, organ involvement. RA typically affects people between the ages of 35 and 60; however, it can also afflict children younger than the age of 16 years and can also demonstrate a pattern of remission later in the disease course. Non-steroidal anti-inflammatory drugs, glucocorticoids, exercise, and patient education are all used in the management of RA, which is divided into symptomatic management and disease-modifying management (disease-modifying antirheumatic drugs) to reduce pain and inflammation, thereby preserving joint function...
May 2024: Curēus
Cesare Furlanello, Nicole Bussola, Nicolò Merzi, Giovanni Pievani Trapletti, Moris Cadei, Rachele Del Sordo, Angelo Sidoni, Chiara Ricci, Francesco Lanzarotto, Tommaso Lorenzo Parigi, Vincenzo Villanacci
BACKGROUND: Inflammatory bowel disease (IBD) includes Crohn's Disease (CD) and Ulcerative Colitis (UC). Correct diagnosis requires the identification of precise morphological features such basal plasmacytosis. However, histopathological interpretation can be challenging, and it is subject to high variability. AIM: The IBD-Artificial Intelligence (AI) project aims at the development of an AI-based evaluation system to support the diagnosis of IBD, semi-automatically quantifying basal plasmacytosis...
June 8, 2024: Digestive and Liver Disease
Anne-Sophie Jannot, Yannick Girardeau, Stanislas Chaussade, Nadine Cerf-Bensussan, Georgia Malamut
BACKGROUND/AIM: We aimed to assess gastrointestinal cancers risks in a large cohort of individuals with primary antibody deficiency (PAD) and their association with risk of autoimmune and inflammatory gastrointestinal diseases. METHODS: Investigating a French national database of inpatient admissions between 2010 and 2018, we identified 12,748 patients with PAD and 38,244 control non-exposed individuals. We performed multiple exposed-non-exposed studies using conditional logistic regression...
June 8, 2024: Digestive and Liver Disease
Yudai Ogata, Atsuko Soeda, Isao Saura, Emi Nemoto, Yoshitaka Tange, Chiaki Enami, Daisuke Ochi, Yuichi Dai, Shintaro Akiyama, Kazuto Ikezawa
Pyoderma gangrenosum (PG) is a sterile inflammatory skin condition that is frequently associated with immune-related diseases, including inflammatory bowel disease (IBD). PG causes noninfectious ulcers. Facial PG is uncommon while PG usually occurs on the trunk and lower limbs. Herein, we report a case of a male teenager with fever, pustules, ulcers, and necrosis on both cheeks. He was initially diagnosed with complicated acne with bacterial infection, but the condition progressed to subcutaneous ulcers despite treatment...
2024: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Yoshiki Okita, Mikio Kawamura, Yuji Toiyama
No abstract text is available yet for this article.
2024: Nihon Shokakibyo Gakkai Zasshi, the Japanese Journal of Gastro-enterology
Yan Li, Yan Wang, Qian Sun, Meng-Ying Li, Jia-Zhou Xu, Yun-Qing Li, Hua Zhang
Ulcerative colitis (UC) is a common inflammatory bowel disease with a complex origin in clinical settings. It is frequently accompanied by negative emotional responses, including anxiety and depression. Enteric glial cells (EGCs) are important components of the gut-brain axis and are involved in the development of the enteric nervous system (ENS), intestinal neuroimmune, and regulation of intestinal motor functions. Since there is limited research encompassing the regulatory function of EGCs in anxiety- and depression-like behaviors induced by UC, this study aims to reveal their regulatory role in such behaviors and associated intestinal inflammation...
June 7, 2024: Neurochemistry International
Mirjam Majster, Sven Almer, Sebastian Malmqvist, Annsofi Johannsen, Ronaldo Lira-Junior, Elisabeth Almer Boström
OBJECTIVE: Calprotectin is elevated in saliva from inflammatory bowel disease (IBD) patients, but it is also affected by oral disease. We assessed the salivary concentration of calprotectin in IBD patients, in relation to intestinal and oral diseases. Furthermore, we investigated the phenotype of salivary neutrophils from IBD patients, and their ability to secrete calprotectin. MATERIALS AND METHODS: Thirty IBD patients and 26 controls were orally examined and sampled for stimulated saliva...
June 9, 2024: Oral Diseases
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