Bruce E Sands, Brian G Feagan, Theresa Hunter Gibble, Kristina A Traxler, Nathan Morris, William J Eastman, Stefan Schreiber, Vipul Jairath, Millie D Long, Alessandro Armuzzi
BACKGROUND: Mirikizumab, an anti-IL-23p19 antibody, demonstrated efficacy in phase 3, randomized, double-blind, placebo-controlled LUCENT-1 (induction/NCT03518086) and LUCENT-2 (maintenance/NCT03524092) ulcerative colitis (UC) studies. We evaluated the effect of mirikizumab on quality-of-life (QoL) outcomes in these studies. METHODS: In LUCENT-1, 1162 patients with moderately-to-severely active UC were randomized 3:1 to receive mirikizumab 300 mg intravenous or placebo every 4 weeks (Q4W) for 12 weeks...
October 2023: Crohn's & colitis 360
A Monleón-Getino, G Pujol-Muncunill, J Méndez Viera, L Álvarez Carnero, W Sanseverino, A Paytuví-Gallart, J Martín de Carpí
Crohn's disease (CD) and ulcerative colitis (UC) are chronic inflammatory bowel diseases (IBD) that affect the gastrointestinal tract. Changes in the microbiome and its interaction with the immune system are thought to play a key role in their development. The aim of this study was to determine whether metagenomic analysis is a feasible non-invasive diagnostic tool for IBD in paediatric patients. A pilot study of oral and faecal microbiota was proposed with 36 paediatric patients divided in three cohorts [12 with CD, 12 with UC and 12 healthy controls (HC)] with 6 months of follow-up...
2023: Frontiers in Pediatrics
Dong Xiang, Ninghong Li, Lu Liu, Hengyi Yu, Xiping Li, Tinghui Zhao, Dong Liu, Xuepeng Gong
Infliximab and its anti -drug antibody (ADA) serum concentrations exhibit a strong correlation with clinical response and loss of response. The use of therapeutic drug monitoring to measure the concentration of infliximab and ADA can facilitate clinical decision-making, helping patients attain optimal therapeutic effects. However, there are still limitations to the existing infliximab and its ADA detection methods. Therefore, this study aimed to develop and validate enzyme-linked immunosorbent assay (ELISA)-based methods for measuring infliximab and its ADA levels in human plasma according to the general recommendations for immunoassays...
November 2023: Heliyon
Antonietta Gerarda Gravina, Raffaele Pellegrino, Giorgia Bodini
No abstract text is available yet for this article.
2023: Frontiers in Medicine
Joel B Winnick, Noel Jacobs, Jennie G David, Mai Ku Moua, Shehzad A Saeed
Care for youth with pediatric inflammatory bowel disease (IBD) is the focus of ImproveCareNow (ICN), an international learning health system devoted to quality care and improved outcomes through collaboration, data sharing, and research. Known to be significantly disruptive to normative social development and quality of life, pediatric IBD significantly increases the risk of internalizing distress and secondary developmental sequelae. While multidisciplinary support including psychosocial care (from social workers and pediatric psychologists) is growing, this evidence-based and beneficial set of services is not universally available to youth with IBD...
November 2023: JPGN reports
Matthew D Swatski, Panamdeep Kaur, Rachel E Borlack, Shonnell McBain, Joshua Uffer, Osama Almadhoun
There have been only 2 reported cases of new-onset ulcerative colitis in pediatrics following acute coronavirus disease 2019 (COVID-19). We are reporting a case series of 3 adolescent female patients, 2 of whom were vaccinated against COVID-19, who developed new-onset ulcerative colitis following a recent diagnosis of COVID-19 infections at a singular pediatric hospital. This case series should be an impetus to clinicians who have pediatric patients with persistent symptoms of hematochezia, diarrhea, and abdominal pain following acute COVID-19 infection to consider further workup for inflammatory bowel disease...
November 2023: JPGN reports
Aldo Majluta Yeb, Evelina Dedic, Braden Olsen, Carole Brathwaite, Roberto Gomara, Erick Hernandez
Extraintestinal manifestations frequently affect patients with inflammatory bowel disease. They can involve virtually any organ, with the musculoskeletal and integumentary systems being the most common. Leukocytoclastic vasculitis is a rare extraintestinal manifestation of inflammatory bowel disease, especially at disease onset. It has been reported to occur in association with Crohn's disease and trimethoprim/sulfamethoxazole (TMP-SMX) exposure independently. We report a case of a 14-year-old female who developed leukocytoclastic vasculitis after exposure to TMP-SMX and was ultimately diagnosed with Crohn's disease...
November 2023: JPGN reports
Leenoy Zaarur, Ashish Patel, Brad Pasternak
The coronavirus disease of 2019 (COVID-19) led to a worldwide pandemic. The emergency use of a combination of nirmatrelvir/ritonavir (paxlovid) was approved for high-risk individuals (such as immunocompromised) testing positive for the disease. We present a patient with ulcerative colitis being treated with tacrolimus, as well as ustekinumab, who was diagnosed with COVID-19 and placed on paxlovid due to her immunosuppressed state. She stopped her tacrolimus while on paxlovid and did well clinically. Tacrolimus was restarted 12 hours after completion of paxlovid, but she became symptomatic with vomiting, headache, and malaise and was found to have a toxic tacrolimus level...
November 2023: JPGN reports
Jennifer L Dotson, Josh Bricker, Deena J Chisolm, Laura M Mackner
OBJECTIVES: Children with inflammatory bowel disease (IBD) have a significant life-long burden as a result of disease, impacted by environmental and individual barriers. Successful health system interventions require a comprehensive approach, informed by various stakeholders. The main objective was to identify health system barriers and potential solutions from existing patients, families, and providers via focus groups. METHODS: Participants for the focus groups were existing English-speaking patients (ages 9-18) with IBD, their caregiver(s), and providers including multiple professions (eg, physician, nurse, pediatrician, social worker, care coordinator, scheduler, and psychologist)...
November 2023: JPGN reports
Lauren V Collen, Peter E Newburger, Scott B Snapper
Glycogen storage disease type 1b (GSD1b) is associated with inflammatory bowel disease and congenital neutropenia. Neutropenia in GSD1b is caused by the accumulation of 1,5-anhydroglucitol-6-phosphate. Empagliflozin is an antidiabetic drug that promotes renal excretion of this metabolite. We report on a patient with refractory GSD1b-associated inflammatory bowel disease who is in clinical remission on empagliflozin monotherapy.
November 2023: JPGN reports
Xu Luo, Rui Wang, Xin Zhang, Xin Wen, Siwei Deng, Wen Xie
BACKGROUND: Recently, heart failure (HF) and inflammatory bowel disease (IBD) have been considered to be related diseases with increasing incidence rates; both diseases are related to immunity. This study aims to analyze and identify immune-related gene (IRG) markers of HF and IBD through bioinformatics and machine learning (ML) methods and to explore their immune infiltration characteristics. METHODS: This study used gene expressiondata (GSE120895, GSE21610, GSE4183) from the Gene Expression Omnibus (GEO) database to screen differentially expressed genes (DEGs) and compare them with IRGs from the ImmPort database to obtain differentially expressed immune-related genes (DIRGs)...
2023: Frontiers in Cardiovascular Medicine
Mei Bai, Hong Guo, Xiao-Yao Zheng
As a frequent complication of inflammatory bowel disease (IBD), Clostridium difficile infection (CDI) was confirmed to not only aggravate the symptoms of IBD but also result in unexpected outcomes, including death. With the increasing prevalence rate of IBD and the updating of CDI diagnosis, the incidence of CDI in IBD patients is also seen rising. Although a detection method consisting of glutamate dehydrogenase immunoassay or nucleic acid amplification test and then toxin A/B enzyme immunoassay was recommended and widely adopted, the diagnosis of CDI in IBD is still a challenge because of the overlap between the symptoms of CDI in IBD and CDI itself...
2023: Therapeutic Advances in Gastroenterology
Satohiro Matsumoto, Yuzo Otaki, Yukio Yoshida, Nobuyuki Kobayashi, Naomi Oka, Hiroyuki Yanagisawa, Kazuhiro Kondo
OBJECTIVE: Inflammatory bowel disease (IBD) is closely related to stress and fatigue. Human herpesvirus 6B (HHV-6B) is reactivated by stress and fatigue and is associated with IBD. This study aimed to clarify the relationship between IBD and HHV-6B. METHODS: Antibody titers to SITH-1, a protein specific to HHV-6B latent infection, were measured in 163 patients with IBD (107 with ulcerative colitis [UC] and 56 with Crohn's disease [CD]); clinical and endoscopic scores and depression scores of UC and CD were analyzed to examine the relationship between SITH-1 and IBD...
November 2023: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
Sam D Papasotiriou, Gregory A Dumanian, Scott A Strong, Stephen B Hanauer
Prolonged perineal wound healing following proctocolectomy in patients with inflammatory bowel disease (IBD) is a frustrating result for the medical team and patients who were hoping for improved quality of life. Prolonged healing, which lasts more than 6 months following proctocolectomy, is termed persistent perineal sinus (PPS) and typically necessitates further surgical management. Healing of the PPS is difficult due to the resulting "dead space" following proctocolectomy, necessitating the need to fill the void with viable tissue in an area with anatomic constraints...
November 2023: JGH Open: An Open Access Journal of Gastroenterology and Hepatology
Xing Wu, Jiahao Xu, Jingbo Li, Minzi Deng, Zhaohua Shen, Kai Nie, Weiwei Luo, Chao Zhang, Kejia Ma, Xuejie Chen, Xiaoyan Wang
BACKGROUND: Patients with inflammatory bowel disease (IBD) have a higher prevalence of depression. Gut microbiota dysbiosis plays an important role in IBD and depression. However, few studies have explored the characteristic microbiota of patients with IBD and depression (IBDD), or their role in IBDD. METHODS: We performed deep metagenomic sequencing and 16S rDNA quantitative PCR to characterise the gut microbial communities of patients with IBDD and patients with IBD without depression (IBDND)...
2023: Frontiers in Microbiology
Arno R Bourgonje, Paola Mian
No abstract text is available yet for this article.
December 1, 2023: American Journal of Gastroenterology
David T Dulaney
Article Title: Preoperative Risk Factors for Adverse Events in Adults Undergoing Bowel Resection for Inflammatory Bowel Disease: 15-Year Assessment of the American College of Surgeons National Surgical Quality Improvement Program.
December 1, 2023: American Journal of Gastroenterology
Shun Yamashita, Masahiko Nakamura, Takashi Akutagawa, Orisa Nakashima, Masaki Tago, Motohiro Esaki, Shu-Ichi Yamashita
BACKGROUND Crohn disease (CD) is a chronic, relapsing inflammatory bowel disease characterized by penetrations or fistulae in the gastrointestinal tract and abscesses in the surrounding tissues. Diagnosis of CD is difficult with an iliopsoas muscle abscess (IMA) as an initial presentation. CASE REPORT A 22-year-old Japanese man had right hip pain 17 days prior to admission. Because of worsening pain, he was admitted to our hospital. Physical examination revealed limitation of his right hip motion and a positive right psoas sign...
November 30, 2023: American Journal of Case Reports
Mirlinda Tahiri, Celine Johnsrud, Inger-Lise Steffensen
This scoping review provides an overview of publications reporting adverse effects on the intestines of the food additives carrageenan (CGN) (E 407)/processed Eucheuma seaweed (PES) (E 407a) and carboxymethylcellulose (CMC) (E 466). It includes evidence from human, experimental mammal and in vitro research publications, and other evidence. The databases Medline, Embase, Scopus, Web of Science Core Collection, Cochrane Database of Systematic Reviews and Epistemonikos were searched without time limits, in addition to grey literature...
November 30, 2023: Critical Reviews in Toxicology
Andreia Rei, Irina Mocanu, Carlos Pontinha, Isabel Medeiros
This case reports illustrates a 44-year-old Caucasian male with ileal Crohn´s disease under combined immunosuppression that first presented with unspecific constitutional symptoms, newly pancytopenia and elevated inflammatory markers. The infectious screening was negative except for an ileal abscess that resolved with conservative antibiotic therapy. Due to concerns for lymphoproliferative disease in a patient under anti-TNF and azathioprine, a myelogram was performed that ruled out dysplastic changes...
November 30, 2023: Revista Española de Enfermedades Digestivas
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