Tomoyoshi Shibuya, Keiichi Haga, Michio Saeki, Mayuko Haraikawa, Hitoshi Tsuchihashi, Koki Okahara, Osamu Nomura, Hirofumi Fukushima, Takashi Murakami, Dai Ishikawa, Shigaku Ikeda, Akihito Nagahara
Pyoderma gangrenosum (PG) is an extra-intestinal skin lesion in inflammatory bowel disease (IBD) as is erythema nodosum. Vedolizumab (VED) is a monoclonal antibody that targets α4β7 integrin and has an intestinal selective mechanism. Despite good therapeutic effects on colitis, the effect on extra-intestinal manifestations (EIMs) remains unclear. Here we report a case of ulcerative colitis complicated by PG during treatment with VED, which was successfully treated with prednisolone in combination with adsorptive granulocyte and monocyte apheresis (GMA)...
August 7, 2020: Journal of Clinical Apheresis
Robert N Lopez, Andrew S Day
No abstract text is available yet for this article.
August 7, 2020: Digestive Diseases and Sciences
Nienke Z Borren, Damian Plichta, Amit D Joshi, Gracia Bonilla, Ruslan Sadreyev, Hera Vlamakis, Ramnik J Xavier, Ashwin N Ananthakrishnan
BACKGROUND: Inflammatory bowel diseases (IBD) are characterized by intermittent relapses, and their course is heterogeneous and unpredictable. Our aim was to determine the ability of protein, metabolite, or microbial biomarkers to predict relapse in patients with quiescent disease. METHODS: This prospective study enrolled patients with quiescent Crohn disease and ulcerative colitis, defined as the absence of clinical symptoms (Harvey-Bradshaw Index ≤ 4, Simple Clinical Colitis Activity Index ≤ 2) and endoscopic remission within the prior year...
August 7, 2020: Inflammatory Bowel Diseases
Walter Reinisch, Silvio Danese, Laurent Peyrin-Biroulet, Edward V Loftus
No abstract text is available yet for this article.
August 7, 2020: Journal of Crohn's & Colitis
Ioannis Varbobitis, Georgios Kokkotis, Michael Gizis, Nikoletta Perlepe, Efrosini Laoudi, Maria Bletsa, Despoina Bekiari, Ioannis Koutsounas, Georgios Kounadis, Vassileios Xourafas, Stilliani Lagou, George Kolios, Ioannis Papakonstantinou, Giorgos Bamias
BACKGROUND: Fatigue is highly prevalent among patients with inflammatory bowel disease (IBD) and may have an unfavorable impact on quality of life (QoL). The IBD-Fatigue scale (with components SCORE1 and SCORE2) is a recently developed disease-specific questionnaire. We sought to validate a Greek version of IBD-F and use it to assess the severity and characteristics of fatigue and its effect on QoL in our study population. METHODS: The IBD-F scale was validated and used to obtain fatigue-related data from patients with IBD attending a tertiary care hospital...
August 7, 2020: Inflammatory Bowel Diseases
Giuseppe Lo Sasso, Lusine Khachatryan, Athanasios Kondylis, James N D Battey, Nicolas Sierro, Natalia A Danilova, Tatiana V Grigoryeva, Maria I Markelova, Dilyara R Khusnutdinova, Alexander V Laikov, Ilnur I Salafutdinov, Yulia D Romanova, Mariia N Siniagina, Ilya Yu Vasiliev, Eugenia A Boulygina, Valeriya V Solovyeva, Ekaterina E Garanina, Kristina V Kitaeva, Konstantin Y Ivanov, Darja S Chulpanova, Konstantin S Kletenkov, Alina R Valeeva, Alfiya Kh Odintsova, Maria D Ardatskaya, Rustam A Abdulkhakov, Nikolai V Ivanov, Manuel C Peitsch, Julia Hoeng, Sayar R Abdulkhakov
BACKGROUND: Several studies have highlighted the role of host-microbiome interactions in the pathogenesis of inflammatory bowel disease (IBD), resulting in an increasing amount of data mainly focusing on Western patients. Because of the increasing prevalence of IBD in newly industrialized countries such as those in Asia, the Middle East, and South America, there is mounting interest in elucidating the gut microbiota of these populations. We present a comprehensive analysis of several IBD-related biomarkers and gut microbiota profiles and functions of a unique population of patients with IBD and healthy patients from Kazan (Republic of Tatarstan, Russia)...
August 7, 2020: Inflammatory Bowel Diseases
Michele Maria Luchetti, Francesco Ciccia, Chiara Avellini, Devis Benfaremo, Aroldo Rizzo, Tatiana Spadoni, Silvia Svegliati, Daniela Marzioni, Alfredo Santinelli, Andrea Costantini, Nadia Viola, Antonella Berretta, Monia Ciferri, Monica Mattioli Belmonte Cima, Piergiorgio Mosca, Antonio Benedetti, Armando Gabrielli
No abstract text is available yet for this article.
August 7, 2020: Rheumatology
Long-Shan Ji, Xue-Hua Sun, Xin Zhang, Zhen-Hua Zhou, Zhuo Yu, Xiao-Jun Zhu, Ling-Ying Huang, Miao Fang, Ya-Ting Gao, Man Li, Yue-Qiu Gao
Helping B cells and antibody responses is a major function of CD4+ T helper cells. Follicular helper T (Tfh) cells are identified as a subset of CD4+ T helper cells, which is specialized in helping B cells in the germinal center reaction. Tfh cells express high levels of CXCR5, PD-1, IL-21, and other characteristic markers. Accumulating evidence has demonstrated that the dysregulation of Tfh cells is involved in infectious, inflammatory, and autoimmune diseases, including lymphocytic choriomeningitis virus (LCMV) infection, inflammatory bowel disease (IBD), systemic lupus erythematosus (SLE), rheumatoid arthritis (RA), IgG4-related disease (IgG4-RD), Sjögren syndrome (SS), and type 1 diabetes (T1D)...
2020: Journal of Immunology Research
Shannon E Conneely, Stacy L Cooper, Rachel E Rau
An essential component of acute lymphoblastic leukemia (ALL) therapy is the prolonged maintenance phase with daily 6-mercaptopurine (6-MP) as the cornerstone. While 6-MP is generally well-tolerated, some patients suffer from significant side effects such as gastrointestinal (GI) toxicity, including hepatitis, hypoglycemia, nausea, and pancreatitis, which can substantially limit the tolerated dose of 6-MP. These toxicities are thought to result from skewed metabolism of 6-MP leading to an accumulation of the 6-methylmercaptopurine (6-MMP) metabolite...
2020: Frontiers in Oncology
Afshin Amini, Elliott Koury, Elie Chahla
A 68-year-old male with a past medical history of interstitial pulmonary fibrosis (IPF) on nintedanib and chronic nintedanib-induced diarrhea for three years presented with hematochezia and worsening diarrhea. Diarrhea had persisted despite the use of cholestyramine and oral antidiarrhea medications. As part of the evaluation of diarrhea, he had undergone colonoscopy two years prior, which had shown non-specific moderate diffuse colitis. No significant abnormalities had been noted on physical exam and lab tests...
July 31, 2020: Curēus
Anna Payne, Nwe Ni Than, Rajiv Jalan, Dominic Yu
Lower gastrointestinal bleeding (LGIB) is a serious and potentially life-threatening condition warranting hospital admission. The most frequent causes include diverticular disease, colitis, hemorrhoids, neoplasm, inflammatory bowel disease, and varices. Varices usually occur secondary to liver cirrhosis and are frequently located in the gastroesophageal region. Those occurring elsewhere are known as ectopic varices. The diagnosis and management of ectopic varices is challenging, and guidelines are not currently available...
July 2, 2020: Curēus
Tiberia Ilias, Simona Bungau, Delia Mirela Tit, Daniela Maghiar, Cristian Hocopan, Roxana Brata, Ovidiu Gabriel Bratu, Nicoleta Negrut, Camelia Diaconu, Ovidiu Fratila
Inflammatory bowel disease (IBD) is a chronic, disabling entity of unknown aetiology, with negative impact on the patient's life, including psychological patterns. This study assessed multiple psychosocial factors (satisfaction with life, coping mechanisms, emotional profile, mental recognition of the disease and cognition schemes related to patients' demographic characteristics, clinical picture, form and duration of the disease, therapeutic plans) in IBD patients vs. a healthy group. This non-interventional study comprised 60 participants who attended for medical advice/check-up as an ambulatory visit or during hospitalization...
September 2020: Experimental and Therapeutic Medicine
Xiaozhi Deng, Lihong Shang, Min Du, Lan Yuan, Lijing Xiong, Xiaoli Xie
Inflammatory bowel disease (IBD) is a term used to describe chronic and recurrent gastrointestinal disease. In total, >2 million individuals worldwide have been diagnosed with IBD, including ulcerative colitis (UC), Crohn's disease (CD) and indeterminate colitis. There is accumulating evidence to indicate that microRNAs (miRNAs or miRs) are involved in the development and progression of IBD. miR-4262, an underlying promoter in tumor diseases, has been reported to regulate inflammatory responses. However, the potential mechanisms underlying the role of miR-4262 in IBD remain unknown...
September 2020: Experimental and Therapeutic Medicine
Amber Hanif Palla, Anwar-Ul-Hassan Gilani, Samra Bashir, Najeeb Ur Rehman
Materials and Methods: Aqueous-methanolic crude extracts of Flaxseed (Fs.Cr) and Flaxseed oil were tested against 6% acetic acid- (AA-) induced colitis in BALB/c mice. Microscopic damage parameters of the hematoxylin and eosin-stained and periodic acid-Schiff-alcian blue-stained sections of the colon were scored to be assessed. Possible antispasmodic mechanism was studied on isolated rabbit jejunum, while antibacterial activity was assessed in vitro for microbes implicated in IBD. Results: In AA-induced colitis, Flaxseed oil was found to be more effective in reducing mortality and colonic ulcers than Fs...
2020: Evidence-based Complementary and Alternative Medicine: ECAM
Alessio Romerio, Francesco Peri
Toll-Like Receptor 4 (TLR4) is one of the receptors of innate immunity. It is activated by Pathogen- and Damage-Associated Molecular Patterns (PAMPs and DAMPs) and triggers pro-inflammatory responses that belong to the repertoire of innate immune responses, consequently protecting against infectious challenges and boosting adaptive immunity. Mild TLR4 stimulation by non-toxic molecules resembling its natural agonist (lipid A) provided efficient vaccine adjuvants. The non-toxic TLR4 agonist monophosphoryl lipid A (MPLA) has been approved for clinical use...
2020: Frontiers in Immunology
Katharina Kappler, Yi Lasanajak, David F Smith, Lennart Opitz, Thierry Hennet
Inflammatory bowel disease is associated with intestinal dysbiosis and with elevated antibody production toward microbial epitopes. The underlying processes linking the gut microbiota with inflammation are still unclear. Considering the constant induction of antibodies by gut microbial glycans, the aim of this study was to address whether the repertoire of carbohydrate-specific antibodies is altered in Crohn's disease or ulcerative colitis. IgG and IgM reactivities to oligosaccharides representative of mucosal glycans were tested in blood serum from 20 healthy control subjects, 17 ulcerative colitis patients, and 23 Crohn's disease patients using glycan arrays...
2020: Frontiers in Microbiology
Guangming Jiang, Renfang Han, Mengya Chen, Rui Liu, Meng Wu, Xu Zhang, Yubo Ma, Yaping Yuan, Ran Wang, Zongwen Shuai, Faming Pan
Many susceptibility genes of inflammatory bowel disease (IBD) are associated with ankylosing spondylitis (AS). Fucosyltransferase 2 (FUT2) and FUT3 genes are related to IBD. This study aimed to investigate whether these genes correlated with the susceptibility to AS. Questionnaires of 673 patients with AS, and peripheral blood specimens of the patients and 687 healthy controls were collected. FUT2 and FUT3 genes were genotyped using the SNPscan method. Frequency differences of the genes at different levels, haplotypes, and interactions were analyzed...
2020: PloS One
Elliot Yi-Hsin Lin, Hsuan-Ju Lai, Yuan-Kai Cheng, Kai-Quan Leong, Li-Chieh Cheng, Yi-Chun Chou, Yu-Chun Peng, Yi-Hsuan Hsu, Hao-Sen Chiang
Aberrant neutrophil extracellular trap (NET) formation and the loss of barrier integrity in inflamed intestinal tissues have long been associated with inflammatory bowel disease (IBD). However, whether NETs alter intestinal epithelium permeability during colitis remains elusive. Here, we demonstrated that NETs promote the breakdown in intestinal barrier function for the pathogenesis of intestinal inflammation in mouse models of colitis. NETs were abundant in the colon of mice with colitis experimentally induced by dextran sulfate sodium (DSS) or 2,4,6-trinitrobenzene sulfonic acid (TNBS)...
August 5, 2020: Biomedicines
Natalia Arias, Silvia Arboleya, Joseph Allison, Aleksandra Kaliszewska, Sara G Higarza, Miguel Gueimonde, Jorge L Arias
Choline is a water-soluble nutrient essential for human life. Gut microbial metabolism of choline results in the production of trimethylamine (TMA), which, upon absorption by the host is converted into trimethylamine-N-oxide (TMAO) in the liver. A high accumulation of both components is related to cardiovascular disease, inflammatory bowel disease, non-alcoholic fatty liver disease, and chronic kidney disease. However, the relationship between the microbiota production of these components and its impact on these diseases still remains unknown...
August 5, 2020: Nutrients
Yoo Min Park, Eunji Ha, Ki-Nam Gu, Ga Young Shin, Chang Kyun Lee, Kwangwoo Kim, Hyo Jong Kim
INTRODUCTION: The family history of inflammatory bowel disease (IBD) has been strongly associated with risk of developing IBD. This study aimed to identify the host genetic and gut microbial signatures in familial IBD. METHODS: Genetic analyses using genome-wide single nucleotide polymorphism genotyping and whole exome sequencing were performed to calculate weighted genetic risk scores from known IBD-associated common variants and to identify rare deleterious protein-altering variants specific to patients with familial IBD in 8 Korean families that each included more than 2 affected first-degree relatives (FDRs) and their unaffected FDR(s)...
July 2020: Clinical and Translational Gastroenterology
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