Kimberley W J van der Sloot, Johan L Tiems, Marijn C Visschedijk, Eleonora A M Festen, Hendrik M van Dullemen, Rinse K Weersma, Gursah Kats-Ugurlu, Gerard Dijkstra
BACKGROUND AND AIMS: Patients with inflammatory bowel disease are at increased risk of colorectal neoplasia (CRN) due to mucosal inflammation. As current surveillance guidelines form a burden on patients and healthcare costs, stratification of high-risk patients is crucial. Cigarette smoke reduces inflammation in ulcerative colitis (UC) but not Crohn's disease (CD) and forms a known risk factor for CRN in the general population. Due to this divergent association, the effect of smoking on CRN in IBD is unclear and subject of this study...
January 13, 2021: Clinical Gastroenterology and Hepatology
Antonio Di Narzo, Itziar Frades, Heidi M Crane, Paul K Crane, Jean-Sebastian Hulot, Andrew Kasarskis, Amy Hart, Carmen Argmann, Marla Dubinsky, Inga Peter, Ke Hao
To further explore genetic links between complex traits, we developed a comprehensive framework to harmonize and integrate extensive genotype and phenotype data from the four well-characterized cohorts with the focus on cardiometabolic diseases deposited to the database of Genotypes and Phenotypes (dbGaP). We generated a series of polygenic risk scores (PRS) to investigate pleiotropic effects of loci that confer genetic risk for 19 common diseases and traits on body height, type 2 diabetes (T2D), and myocardial infarction (MI)...
January 16, 2021: Human Genetics
Matteo Bramuzzo, Paolo Lionetti, Erasmo Miele, Claudio Romano, Serena Arrigo, Sabrina Cardile, Giovanni Di Nardo, Maria Teresa Illiceto, Maria Pastore, Enrico Felici, Maurizio Fuoti, Claudia Banzato, Michele Citrano, Mauro Congia, Lorenzo Norsa, Elena Pozzi, Giovanna Zuin, Anna Agrusti, Martina Bianconi, Claudia Grieco, Fabiola Giudici, Marina Aloi, Patrizia Alvisi
BACKGROUND: Adult patients with both inflammatory bowel disease (IBD) and celiac disease (CeD) have peculiar phenotypic features. This study aimed at describing the characteristics and natural history of children with both IBD and CeD. METHODS: This was a case-control study based on a national registry. Cases included children diagnosed with both IBD and CeD. Two matched IBD controls without CeD, and 2 matched CeD controls were selected for each case. Inflammatory bowel disease phenotype and natural history, comprising growth and pubertal development, were compared between groups...
January 16, 2021: Inflammatory Bowel Diseases
Giovanni Di Nardo, Paolo Quitadamo, Mara Quatrini, Francesco Malfona, Maria Luisa Moleti, Ursula La Rocca, Margherita Velardi, Pasquale Parisi, Anna Maria Testi
No abstract text is available yet for this article.
January 16, 2021: Inflammatory Bowel Diseases
Allison D Ta, Nicholas J Ollberding, Rebekah Karns, Yael Haberman, Adina L Alazraki, David Hercules, Robert Baldassano, James Markowitz, Melvin B Heyman, Sandra Kim, Barbara Kirschner, Jason M Shapiro, Joshua Noe, Maria Oliva-Hemker, Anthony Otley, Marian Pfefferkorn, Richard Kellermayer, Scott Snapper, Shervin Rabizadeh, Ramnik Xavier, Marla Dubinsky, Jeffrey Hyams, Subra Kugathasan, Anil G Jegga, Jonathan R Dillman, Lee A Denson
BACKGROUND: Transmural healing (TH) is associated with better long-term outcomes in Crohn disease (CD), whereas pretreatment ileal gene signatures encoding myeloid inflammatory responses and extracellular matrix production are associated with stricturing. We aimed to develop a predictive model for ileal TH and to identify ileal genes and microbes associated with baseline luminal narrowing (LN), a precursor to strictures. MATERIALS AND METHODS: Baseline small bowel imaging obtained in the RISK pediatric CD cohort study was graded for LN...
January 16, 2021: Inflammatory Bowel Diseases
Unmesha Roy Paladhi, Ali H Harb, Scott G Daniel, Ghadeer K Dawwas, Erin M Schnellinger, Colin Wollack, Faten N Aberra, Meenakshi Bewtra, Jesse A Green, Jan-Michael A Klaproth, Gary R Lichtenstein, Akriti Saxena, Shivali Berera, Anna Buchner, Shivan J Mehta, Mark T Osterman, Farzana Rashid, Vesselin Tomov, Freddy Caldera, Saha Sumona, Uma Mahadevan, Abhik Roy, Lisa Nessel, Gary D Wu, Kyle Bittinger, James D Lewis
No abstract text is available yet for this article.
January 16, 2021: Inflammatory Bowel Diseases
Nilesh Chande, Siddharth Singh, Neeraj Narula, Morris Gordon, M Ellen Kuenzig, Tran M Nguyen, John K MacDonald, Brian G Feagan
No abstract text is available yet for this article.
January 16, 2021: Inflammatory Bowel Diseases
Mabrouka Salem, Joanna Lecka, Julie Pelletier, Danielle Gomes Marconato, Aline Dumas, Luc Vallières, Gaetan Brochu, Bernard Robaye, Christian Jobin, Jean Sévigny
OBJECTIVE: Nucleotides are danger signals that activate inflammatory responses via binding P2 receptors. The nucleoside triphosphate diphosphohydrolase-8 (NTPDase8) is an ectonucleotidase that hydrolyses P2 receptor ligands. We investigated the role of NTPDase8 in intestinal inflammation. DESIGN: We generated NTPDase8-deficient ( Entpd8 -/- ) mice to define the role of NTPDase8 in the dextran sodium sulfate (DSS) colitis model. To assess inflammation, colons were collected and analysed by histopathology, reverse transcriptase-quantitative real-time PCR (RT-qPCR) and immunohistochemistry...
January 15, 2021: Gut
Zhen Ding, Weijun Wang, Kun Zhang, Fanhua Ming, Tianyi Yangdai, Tao Xu, Huiying Shi, Yuhui Bao, Hailing Yao, Hangyu Peng, Chaoqun Han, Weiwei Jiang, Jun Liu, Xiaohua Hou, Rong Lin
OBJECTIVE: Intestinal flora and metabolites are associated with multiple systemic diseases. Current approaches for acquiring information regarding microbiota/metabolites have limitations. We aimed to develop a precise magnetically controlled sampling capsule endoscope (MSCE) for the convenient, non-invasive and accurate acquisition of digestive bioinformation for disease diagnosis and evaluation. DESIGN: The MSCE and surgery were both used for sampling both jejunal and ileal GI content in the control and antibiotic-induced diarrhoea groups...
January 15, 2021: Gut
Carlos Machahua, Sabina A Guler, Michael P Horn, Lurdes Planas-Cerezales, Ana Montes-Worboys, Thomas K Geiser, Maria Molina-Molina, Manuela Funke-Chambour
BACKGROUND: Non-invasive biomarkers for the assessment of disease severity in idiopathic pulmonary fibrosis (IPF) are urgently needed. Calprotectin belongs to the S-100 proteins produced by neutrophils, which likely contribute to IPF pathogenesis. Calprotectin is a well-established biomarker in inflammatory bowel diseases. In this cross-sectional study, we aimed to establish the potential role of calprotectin as a biomarker in IPF. Specifically, we hypothesised that patients with IPF have higher serum calprotectin levels compared with healthy controls, and that calprotectin levels are associated with disease severity...
January 2021: BMJ Open Respiratory Research
Fernando Rizzello, Carlo Calabrese, Marco Salice, Lucia Calandrini, Hana Privitera, Laura Melotti, Giulia Peruzzi, Nikolas Dussias, Andrea Belluzzi, Eleonora Scaioli, Anastasio Decorato, Antonio Siniscalchi, Eleonora Filippone, Silvio Laureti, Matteo Rottoli, Gilberto Poggioli, Paolo Gionchetti
BACKGROUND: Italy has been one of the most affected countries in the world by COVID-19. There has been increasing concern regarding the impact of COVID-19 on patients with inflammatory bowel disease (IBD), particularly in patients treated with immunosuppressants or biologics. The aim of our study is to understand the incidence of COVID-19 in a large cohort of patients with IBD. Furthermore, we analyzed possible risk factors for infection and severity of COVID-19. METHODS: This was an observational study evaluating the impact of COVID-19 on IBD patients in a single tertiary center...
December 26, 2020: Digestive and Liver Disease
Alicja Ewa Ratajczak, Aleksandra Szymczak-Tomczak, Agnieszka Zawada, Anna Maria Rychter, Agnieszka Dobrowolska, Iwona Krela-Kaźmierczak
Patients suffering from Crohn's disease and ulcerative colitis are at higher risk of osteoporosis due to lower bone mineral density. Risk factors of osteoporosis are divided into unmodifiable, namely, age, gender, genetic factors, as well as modifiable, including diet, level of physical activity, and the use of stimulants. Coffee and tea contain numerous compounds affecting bone metabolism. Certain substances such as antioxidants may protect bones; other substances may increase bone resorption. Nevertheless, the influence of coffee and tea on the development and course of inflammatory bowel diseases is contradictory...
January 13, 2021: Nutrients
Georges Tarris, Alexis de Rougemont, Maëva Charkaoui, Christophe Michiels, Laurent Martin, Gaël Belliot
Inflammatory bowel diseases (IBD), including ulcerative colitis (UC) and Crohn's disease (CD), is a multifactorial disease in which dietary, genetic, immunological, and microbial factors are at play. The role of enteric viruses in IBD remains only partially explored. To date, epidemiological studies have not fully described the role of enteric viruses in inflammatory flare-ups, especially that of human noroviruses and rotaviruses, which are the main causative agents of viral gastroenteritis. Genome-wide association studies have demonstrated the association between IBD, polymorphisms of the FUT2 and FUT3 genes (which drive the synthesis of histo-blood group antigens), and ligands for norovirus and rotavirus in the intestine...
January 13, 2021: Viruses
Sheetal Parida, Sumit Siddharth, Dipali Sharma
Lung cancer remains the second-most-common cancer worldwide and is associated with the highest number of cancer-related mortality. While tobacco smoking is the most important risk factor for lung cancer, many other lifestyles and occupational factors significantly contribute. Obesity is a growing global health concern and contributes to ~30% cancer-related mortality, but unlike other lifestyle diseases, lung cancer is negatively associated with obesity. We meta-analyzed multiple case-control studies confirming increased survival and better outcomes in overweight and obese lung cancer patients...
January 13, 2021: Cancers
Shintaro Sagami, Kiyohiro Nishikawa, Fumika Yamada, Yasuo Suzuki, Mamoru Watanabe, Toshifumi Hibi
BACKGROUND AND AIM: CT-P13, an infliximab (IFX) biosimilar, was approved for treatment of inflammatory bowel disease. However, no comparison with the originator IFX in this indication has been conducted in Japan where endemic levels of tuberculosis and hepatitis virus infection are not low. We evaluated the safety and efficacy in real-world data of CT-P13 and compared with originator IFX data in Japan. METHODS: In a prospective post-marketing surveillance (PMS) study, patients who received CT-P13 in a 28-month period from January 2015 were followed up for 2 years...
January 15, 2021: Journal of Gastroenterology and Hepatology
Jamie Zhen, John K Marshall, Geoffrey C Nguyen, Ashish Atreja, Neeraj Narula
Technological advances now permit self-management strategies using mobile applications which could greatly benefit patient care. The purpose of this study was to investigate whether the use of the inflammatory bowel disease (IBD) digital health monitoring platform, HealthPROMISE, leads to better quality of care and improved health outcomes in IBD patients. IBD patients were recruited in gastroenterology clinics and asked to install the HealthPROMISE application onto their smartphones. Patient satisfaction, quality of care, quality of life, patient symptoms, and resource utilization metrics were collected throughout the study and sent directly to their healthcare teams...
January 15, 2021: Journal of Medical Systems
Lalin Navaratne, Katherine-Helen Hurndall, Daniel M Richardson, Robert Stephenson, Niall Power, Holly Gillott, Susana Ruiz Sánchez, Kuresh Khodatars, Christopher Lh Chan
AIM: Crohn's disease is a chronic inflammatory bowel disease characterised by alternating periods of exacerbation and remission. Surgical resection is not curative and post-operative recurrence (POR) remains a challenge in these patients. The aim of this study was to identify clinical variables that influence the risk of symptomatic anastomotic POR in patients with ileocolonic Crohn's disease. METHODS: Retrospective study of Crohn's disease patients who had undergone ileo-colic resection between January 2014 and December 2018 was performed...
January 15, 2021: Colorectal Disease
Hadeel A Alsufyani, Mahmoud H Mosli, Omar I Saadah
BACKGROUND AND AIMS: Children with inflammatory bowel disease (IBD) generally show an alteration in their fat and soft tissue mass contents. These alterations may influence disease severity and increase the risk of post-operative complications. METHODS: This is a retrospective cross-sectional study of patients with IBD, diagnosed and followed up between 2013 and 2018, in Jeddah, Saudi Arabia, who had dual-energy x-ray absorptiometry (DXA) scans for bone density evaluation...
January 14, 2021: International Journal of Clinical Practice
Ewa Baranowska-Wójcik
The recent years have seen a significant interest in the applications of nanotechnology in various facets of our lives. Due to their increasingly widespread use, human exposure to nanoparticles (NPs) is fast becoming unavoidable. Among the wide group of nanoparticles currently employed in industry, titanium dioxide nanoparticles, TiO2 NPs, are particularly popular. Due to its white colour, TiO2 is widely used as a whitening food additive (E 171). Yet, there have been few studies aimed at determining its direct impact on bacteria, while the available data suggest that TiO2 NPs may influence microbiota causing problems such as inflammatory bowel disease, obesity, or immunological disorders...
January 14, 2021: Biological Trace Element Research
Kai Qian, Jia-Xin Xu, Yi Deng, Hao Peng, Jun Peng, Chun-Mei Ou, Zu Liu, Li-Hong Jiang, Yong-Hang Tai
Background: Myasthenia gravis (MG) is a chronic autoimmune neuromuscular disorder causing muscle weakness and characterized by a defect in synaptic transmission at the neuromuscular junction. The pathogenesis of this disease remains unclear. We aimed to predict the key signaling pathways of genetic variants and miRNAs in the pathogenesis of MG, and identify the key genes among them. Methods: We searched published information regarding associated single nucleotide polymorphisms (SNPs) and differentially-expressed miRNAs in MG cases...
December 2020: Gland Surgery
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